An efficient and facile synthesis of polydentate ligand: pyridylpyrimidine-2-amine under solvent-free conditions

ZrOCl2/nano TiO2 as an Efficient Catalyst for the One Pot Synthesis of Naphthopyranopyrimidines Under Solvent-free Conditions

“…[7][8][9][10][11] The eco-friendly, solvent-free multicomponent approach opens up numerous possibilities for environmentally clean synthesis which involves reduction or elimination of the use or generation of hazardous chemicals. [12][13] The possibility of performing multicomponent reactions under solvent-free conditions with a heterogeneous catalyst could improve their cost-effectiveness and ecological acceptability. Nanoparticles exhibit good catalytic activity due to their high surface-to-volume ratio in comparison to their heterogeneous counterparts.…”

Effects of different types of nuclear radiations on optically stimulated luminescence

“…An easy and highly efficient 1-pot reaction for the preparation of 4-aryl-6-(pyridin-2-yl)pyrimidin-2-amine 12 via the reaction of different aromatic aldehydes 4, acetylpyridine 11, and guanidinium carbonate 6 in the presence of NaOH under solvent-free conditions was reported by Tao et al (Scheme 3). 16 Rong et al reported a mild protocol for the synthesis of 4-naphthylpyrimidin-2-amine derivatives 14 (or 16) by the reaction of aromatic aldehydes 4 (or 1-naphthaldehyde 15), 2-acetylnaphthalene 13 (or acetophenones 5) with guanidinium carbonate 6 in the presence of sodium hydroxide under solvent-free conditions (Schemes The heterocyclic pyrido [2,3-d ]pyrimidines ring system represents several biological activities. Some analogues have been found to act as antitumor agents inhibiting dihydrofolate reductases or tyrosine kinases, 20−22 while others are known antiviral agents.…”