An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones

Аксенов, Дмитрий А.; Akulova, Alesia S.; Aleksandrova, E. A.; Аксенов, Н. А.; Leontiev, Alexander V.; Аксенов, А. В.

doi:10.3390/molecules28052324

Molecules

2023

DOI: 10.3390/molecules28052324

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An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones

Дмитрий А. Аксенов

Alesia S. Akulova

E. A. Aleksandrova

et al.

Abstract: A straightforward three-step procedure affording a wide range of novel 7-aryl substituted paullone derivatives was developed. This scaffold is structurally similar to 2-(1H-indol-3-yl)acetamides—promising antitumor agents—hence, could be useful for the development of a new class of anticancer drugs.

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A Green and Convenient Approach for the Synthesis of Indole-acrylonitrile and Indole-coumarin Hybrids in Aqueous Media

Zonouz,

Moghani

2024

LOC

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Indole–acrylonitrile hybrids were synthesized via a catalyst-free reaction of aromatic aldehydes and 3-(cyanoacetyl)indole in aqueous media. Also, indole-coumarin hybrids were synthesized via a domino reaction of salicylaldehyde derivatives and 3-(cyanoacetyl)indole in the presence of ammonium acetate in aqueous media. The advantages of the present protocol are high yields, short reaction times, mild reaction conditions, operational simplicity, and environmentally benign, and also there is no need to purification of products. objective: The development of hybrid molecules through the combination of indole and other heterocycles may lead to compounds with interesting biological activity. method: The Knoevenagel condensation reaction of 3-(cyanoacetyl)indole with benzaldehyde derivatives was carried out in EtOH/H2O 1:1 in reflux condition and 3-aryl-2-(1H-indol-3-ylcarbonyl)acrylonitrile 3a-h were obtained in excellent yields. The indole-coumarin hybrids 5a-g were obtained from the reaction of salicylaldehyde derivatives and 3-(cyanoacetyl)indole in EtOH/H2O (2:1) in the presence of 1 equivalent ammonium acetate as a catalyst at reflux condition.

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A Green and Convenient Approach for the Synthesis of Indole-acrylonitrile and Indole-coumarin Hybrids in Aqueous Media

Zonouz,

Moghani

2024

LOC

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show abstract

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An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones

Cited by 1 publication

References 37 publications

A Green and Convenient Approach for the Synthesis of Indole-acrylonitrile and Indole-coumarin Hybrids in Aqueous Media

A Green and Convenient Approach for the Synthesis of Indole-acrylonitrile and Indole-coumarin Hybrids in Aqueous Media

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