An effective mosquito-repellent topical product from liquid crystal-based tea tree oil

Fonseca-Santos, Bruno; Pacheco, Camila Del Nero; Pinto, Mara Cristina

doi:10.1016/j.indcrop.2018.11.020

Cited by 16 publications

(4 citation statements)

References 107 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Through the rheograms, it is observed that the shear stress increases as the strain rate increases, characterizing the cosmetics studied as being pseudoplastic fluids, similar to the behavior found by Wang et al (2019), Rigon et al (2019), Fonseca-Santos et al (2019) and Tomic ´ et al (2019 who studied cosmetics and drugs made with different incipients.…”

Section: Viscosity Analysissupporting

confidence: 72%

Quality of cosmetics with active caffeine in cream and gel galenic bases prepared by compounding pharmacies

et al. 2022

View full text Add to dashboard Cite

As there is a great scarcity of studies on the importance of good compounding practices in the preparation of cosmetics, this study aimed to evaluate the quality control of cosmetics with active ingredient caffeine for the treatment of cellulite prepared by magistrals pharmacies. Microbiological analyzes, pH determination, color measurement, quantification of the percentage of the active ingredient caffeine and viscosity in creams and gels with 5% of the active ingredient caffeine were performed. In the microbiological analysis, the presence of molds and yeasts was verified above the permitted level according to the Brazilian pharmacopoeia. The pH decreased over time, contributing to the formulations becoming more acidic. In the color parameters, it was found that pharmacy F4 showed a brownish color, both for the gel and for the cream. The percentage of caffeine was within specifications in all formulations and the viscosity remained unchanged during the shelf life of the samples. It is important that the compounding pharmacies demand more effectively the commitment of the team, as well as the analysis of the raw material according to the microbiological control regulations to translate into the quality of the products prepared by the pharmacies and favor the consumer in the effective objective that the product you want to achieve.

show abstract

Section: Viscosity Analysissupporting

confidence: 72%

Quality of cosmetics with active caffeine in cream and gel galenic bases prepared by compounding pharmacies

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Dengue spread by Aedes aegypti (L.) and Aedes albopictus (Skuse), is closely associated with human residences in metropolises 5 – 7 . Mosquito borne infections have been documented to be a principal contributing cause to illness amongst long-term expatriates, travellers, and military units deployed overseas, especially in tropical and sub-tropical areas 8 . Various major and minor epidemics amongst the US and foreign military have been recorded when deployed to malaria-endemic areas of West Africa, North Africa, the South Pacific and the China–Burma–India borders during World War II, the Korean War, and Vietnam Conflict 9 – 11 .…”

Section: Introductionmentioning

confidence: 99%

The fabrication and assessment of mosquito repellent cream for outdoor protection

Hazarika

Krishnatreyya

Tyagi³

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Mosquito-borne infections like dengue, malaria, chikungunya, etc. are a nuisance and can cause profound discomfort to people. Due to the objectional side effects and toxicity associated with synthetic pyrethroids, N,N-diethyl-3-methylbenzamide (DEET), N,N-diethyl phenylacetamide (DEPA), and N,N-di ethyl benzamide (DEBA) based mosquito repellent products, we developed an essential oil (EO) based mosquito repellent cream (EO-MRC) using clove, citronella and lemongrass oil. Subsequently, a formulation characterization, bio-efficacy, and safety study of EO-MRC were carried out. Expression of Anti-OBP2A and TRPV1 proteins on mosquito head parts were studied by western blotting. In-silico screening was also conducted for the specific proteins. An FT-IR study confirmed the chemical compatibility of the EOs and excipients used in EO-MRC. The thermal behaviour of the best EOs and their mixture was characterized by thermogravimetric analysis (TGA). GC–MS examination revealed various chemical components present in EOs. Efficacy of EO-MRC was correlated with 12% N,N-diethyl benzamide (DEBA) based marketed cream (DBMC). Complete protection time (CPT) of EO-MRC was determined as 228 min. Cytotoxicity study on L-132 cell line confirmed the non-toxic nature of EO-MRC upon inhalation. Acute dermal irritation study, acute dermal dose toxicity study, and acute eye irritation study revealed the non-toxic nature of EO-MRC. Non-target toxicity study on Danio rerio confirmed EO-MRC as safer for aquatic non-target animals. A decrease in the concentration of acetylcholinesterase (AChE) was observed in transfluthrin (TNSF) exposed Wistar rats. While EO-MRC did not alter the AChE concentrations in the exposed animals. Results from western blotting confirmed that Anti-OBP2A and TRPV1 proteins were inhibited in TNSF exposed mosquitoes. Mosquitoes exposed to EO-MRC showed a similar expression pattern for Anti-OBP2A and TRPV1 as the control group. In silico study revealed eight identified compounds of the EOs play significant roles in the overall repellency property of the developed product. The study emphasizes the mosquito repellent activity of EO-MRC, which could be an effective, eco-friendly, and safer alternative to the existing synthetic repellents for personal protection against mosquitoes during field conditions.

show abstract

“…To this end, skin care products and cosmetics have been formulated to exbibit pseudoplastic behavior, and among these products, we can refer to examples of emulsions and lotions [ 57 , 58 , 59 ], microemulsions [ 60 , 61 ], hydrogels [ 61 , 62 , 63 ], and lyotropic liquid crystals [ 45 , 64 , 65 ]. Previous studies performed by our group demonstrated that lyotropic liquid crystals designed with other surfactants and natural oils are ideal for formulating Non-Newtonian fluids, showing pseudoplastic behavior and thixotropic characteristics [ 46 , 47 , 66 ].…”

Section: Resultsmentioning

confidence: 99%

Design and Characterization of Lipid-Surfactant-Based Systems for Enhancing Topical Anti-Inflammatory Activity of Ursolic Acid

et al. 2023

Self Cite

View full text Add to dashboard Cite

Skin inflammation is a symptom of many skin diseases, such as eczema, psoriasis, and dermatitis, which cause rashes, redness, heat, or blistering. The use of natural products with anti-inflammatory properties has gained importance in treating these symptoms. Ursolic acid (UA), a promising natural compound that is used to treat skin diseases, exhibits low aqueous solubility, resulting in poor absorption and low bioavailability. Designing topical formulations focuses on providing adequate delivery via application to the skin surface. The aim of this study was to formulate and characterize lipid-surfactant-based systems for the delivery of UA. Microemulsions and liquid crystalline systems (LCs) were characterized by polarized light microscopy (PLM), rheology techniques, and textural and bioadhesive assays. PLM supported the self-assembly of these systems and elucidated their formation. Rheologic examination revealed pseudoplastic and thixotropic behavior appropriate, and assays confirmed the ability of these formulations to adhere to the skin. In vivo studies were performed, and inflammation induced by croton oil was assessed for response to microemulsions and LCs. UA anti-inflammatory activities of ~60% and 50% were demonstrated by two microemulsions and 40% and 35% by two LCs, respectively. These data support the continued development of colloidal systems to deliver UA to ameliorate skin inflammation.

show abstract

An effective mosquito-repellent topical product from liquid crystal-based tea tree oil

Cited by 16 publications

References 107 publications

Quality of cosmetics with active caffeine in cream and gel galenic bases prepared by compounding pharmacies

Quality of cosmetics with active caffeine in cream and gel galenic bases prepared by compounding pharmacies

The fabrication and assessment of mosquito repellent cream for outdoor protection

Design and Characterization of Lipid-Surfactant-Based Systems for Enhancing Topical Anti-Inflammatory Activity of Ursolic Acid

Contact Info

Product

Resources

About