An effective method for fast determination of artemisinin in Artemisia annua L. by high performance liquid chromatography with evaporative light scattering detection

Liu, Chun-Zhao; Zhou, Hua-Ying; Zhao, Yan

doi:10.1016/j.aca.2006.08.038

Cited by 61 publications

(24 citation statements)

References 22 publications

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“…Table 1 shows the results of quantitative analysis of A. annua samples by ELISA. The results for AM content in Chinese wormwoods were similar to those reported previously [37,38]. However, other AM-related compounds which are recognized by the mAb 1C1 may affect these qualitative data.…”

Section: Evaluation and Application Of Icelisa Using Anti-am Mabsupporting

confidence: 78%

Immunochemical Analysis of the Antimalarial Drugs Artemisinin and Artesunate

et al. 2012

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Abstract:We prepared a monoclonal antibody (mAb 1C1) showing specificity for artemisinin (AM) and artesunate (AS), and we developed an indirect competitive enzymelinked immunosorbent assay (icELISA) using this novel mAb. Moreover, we prepared a recombinant antibody derived from mAb 1C1 in order to overcome insufficient mAb production by hybridoma culture. A recombinant antigen-binding fragment (Fab) was easily constructed using antibody manipulation technologies and was produced by microorganisms in high yield. We herein review immunochemical approaches for analysis of the antimalarial drugs AM and AS that were able to yield analysis results for multiple samples in a short period of time using simple and reliable protocols.

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Section: Evaluation and Application Of Icelisa Using Anti-am Mabsupporting

confidence: 78%

Immunochemical Analysis of the Antimalarial Drugs Artemisinin and Artesunate

et al. 2012

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“…Organic solvent fractions were evaporated and the residue was dissolved in 200 ml MeOH accurately. Determination of artemisinin was performed on the HPLC-ELSD system equipped with a Venusil XBP-C 18 column (C 18 , 200 mm £ 4.6 mm, 5 mm) as the literature reported [8].…”

Section: Resultsmentioning

confidence: 99%

Three new triterpenoid saponins from the leaves and stems ofPanax quinquefolium

Chen

Zhao

Zeng

et al. 2009

Journal of Asian Natural Products Research

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Three new minor dammarane saponins, quinquenosides L10 (1), L14 (2), and L16 (3), were isolated from the leaves and stems of Panax quinquefolium L. By the combination of one- and two-dimensional NMR techniques and MS spectroscopic analysis, their structures were established as 20-O-(alpha-L-arabinopyranosyl-(1-6)-O-beta-D-glucopyranosyl)-3-O-beta-D-glucopyranosyl-dammar-24-ene-3,12, 20-triol (1), 20-O-alpha-L-arabinopyranosyl-3-O-(beta-D-glucopyranosyl-(1-2)-O-beta-d-glucopyranosyl)-dammar-24-ene-3,12,20-triol (2), 3-O-(beta-D-glucopyranosyl-(1-2)-O-beta-d-glucopyranosyl)-20-O-(beta-D-glucopyranosyl-(1-6)-beta-D-glucopyranosyl)-dammarane-3,12,20,24,25-pentaol (3). The content of artemisinin was significantly enhanced by 3.0 mg l(- 1) of compounds 1, 2, and 3 in the callus of Artemisia annua.

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“…[12] However, there are only a few examples in the literature in which this methodology has been applied to antimalarial drug discovery. Microwave irradiation was exploited for the isolation of artemisinin, [13] and for the synthesis of quinoline derivatives by a Friedländer two-component condensation. [14] However, direct access to substituted 4-aminoquinolines from haloquinolines through S N Ar reactions remains unexplored.…”

Section: Introductionmentioning

confidence: 99%

Novel 4‐Aminoquinolines through Microwave‐Assisted S_NAr Reactions: a Practical Route to Antimalarial Agents

et al. 2007

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Abstract4‐Aminoquinolines have recently been indicated to be an important class of chemotherapeutic agents for artemisinin‐based antimalarial combination therapy. A rapid, cheap, possibly clean and scalable route to 4‐aminoquinolines endowed with multiple diversity is therefore badly needed. Classically, they have been prepared by means of SNAr reactions, requiring hazardous or costly reagents and conditions and complex purification procedures. In this paper, microwave flash‐heating chemistry is shown to allow the efficient conversion of the available 4,7‐dichloroquinoline into a library of aminoquinolines in high yields and purities, with no need for further purification steps and requiring very short reaction times. Some of the compounds in this library were active against chloroquine‐sensitive and chloroquine‐resistant parasite strains.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

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An effective method for fast determination of artemisinin in Artemisia annua L. by high performance liquid chromatography with evaporative light scattering detection

Cited by 61 publications

References 22 publications

Immunochemical Analysis of the Antimalarial Drugs Artemisinin and Artesunate

Immunochemical Analysis of the Antimalarial Drugs Artemisinin and Artesunate

Three new triterpenoid saponins from the leaves and stems ofPanax quinquefolium

Novel 4‐Aminoquinolines through Microwave‐Assisted S_NAr Reactions: a Practical Route to Antimalarial Agents

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An effective method for fast determination of artemisinin in Artemisia annua L. by high performance liquid chromatography with evaporative light scattering detection

Cited by 61 publications

References 22 publications

Immunochemical Analysis of the Antimalarial Drugs Artemisinin and Artesunate

Immunochemical Analysis of the Antimalarial Drugs Artemisinin and Artesunate

Three new triterpenoid saponins from the leaves and stems ofPanax quinquefolium

Novel 4‐Aminoquinolines through Microwave‐Assisted SNAr Reactions: a Practical Route to Antimalarial Agents

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Product

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Novel 4‐Aminoquinolines through Microwave‐Assisted S_NAr Reactions: a Practical Route to Antimalarial Agents