An effective and reliable marker in grading the severity of acute cholecystitis: increased immature granulocyte percentage

Ünal, Yasemin; Tuncal, Salih; Küçük, Berkay; Barlas, Aziz Mutlu; Altıner, Saygın; Balık, Recep; Aydın, Seyit Murat; Şenlikçi, Abdullah; Pekcici, Mevlüt Recep

doi:10.14744/tjtes.2021.86322

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…IG% has been shown to provide valuable insights into disease severity in conditions with severe inflammation, such as acute necrotizing pancreatitis, acute cholecystitis, and perforated appendicitis. [ 12 , 13 , 29 , 30 ] However, some studies indicate that IG% might not offer additional benefits compared to other inflammatory markers. [ 31 , 32 ] In our study, no statistically significant difference in IG% values was found between complicated and uncomplicated acute diverticulitis patients.…”

Section: Discussionmentioning

confidence: 99%

The role of infectious parameters in the early prediction of complicated colonic diverticulitis

Aydın

2024

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Acute colonic diverticulitis has recently become a significant cause of hospital admissions. Complicated colonic diverticulitis, a severe form of the disease, necessitates medical and surgical intervention. Prompt diagnosis in these patients is crucial. This study aims to assess the role of infectious parameters in the early diagnosis of complicated colonic diverticulitis. METHODS: This retrospective study analyzed 82 adult patients diagnosed with acute diverticulitis. Recorded data included patient demographics, hospital stay duration, disease location, and surgical procedures. Infectious parameters such as white blood cell count (WBC), C-reactive protein (CRP), neutrophil/lymphocyte ratio (NLR), percentage of immature granulocytes (IG%), and systemic immune-inflammatory index (SII) were calculated and noted. Patients underwent abdominal computed tomography upon admission, and based on these results, they were categorized into uncomplicated or complicated diverticulitis groups. Statistical analysis was performed to identify differences between these groups. RESULTS: CRP, NLR, and SII were significantly more predictive of complicated acute colonic diverticulitis. However, no statistical differences in WBC and IG% values were observed between the groups. CONCLUSION: The study found that the percentage of immature granulocytes, previously deemed a reliable marker in many studies, did not significantly predict complicated colonic diverticulitis. Further comprehensive studies are necessary to explore inflammatory markers in colonic diverticulitis more thoroughly.

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Section: Discussionmentioning

confidence: 99%

The role of infectious parameters in the early prediction of complicated colonic diverticulitis

Aydın

2024

Ulus Travma Acil Cerrahi Derg

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“…В норме незрелые гранулоциты в периферической крови отсутствуют и появляются только при развитии неопластических и инфекционно-воспалительных процессов. Показана положительная корреляционная связь этого показателя с уровнем лейкоцитов и прокальцитонина при инфекционно-воспалительных процессах [10,11]. При анализе относительного количества незрелых гранулоцитов в группах с благоприятным и неблагоприятным исходом выявлено, что в точке 1 показатели IG статистически значимо не различались у выживших и умерших пациентов (1,2 (0,7; 2,1)% vs 0,8 (0,6; 1,5)%, соответственно, р>0,05).…”

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Early Clinical and Laboratory Predictors of Hospital Mortality in Patients with Sepsis Secondary to Pneumonia

Rodionova,

Starovoitova,

Fedosenko

et al. 2024

Arhivʺ vnutrennej mediciny

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Despite significant progress in the field of prevention, early diagnosis and antibacterial therapy, community-acquired pneumonia still retains the status of not only the most common among acute infectious diseases, but is also a frequent source of sepsis, which greatly increases the likelihood of death in this group of patients. The purpose of the study was to perform a comparative analysis of clinical and laboratory parameters and assess the nature of their changes in the first 48 hours from the moment of verification of sepsis that developed against the background of pneumonia in patients of the therapeutic department, depending on the outcome of hospitalization.Clinical groups and research methods. A retrospective comparative study was carried out, which included, using a continuous sampling method, patients with sepsis that developed against the background of pneumonia in patients hospitalized in therapeutic clinics of the Federal State Budgetary Educational Institution of Higher Education Siberian State Medical University of the Ministry of Health of Russia in the period from 01/01/2019 to 04/30/2023. In total, the study included 40 patients of both gender, followed by division into two comparison groups depending on the outcome of hospitalization (discharge from hospital or death) for the dynamic assessment of clinical, anamnestic and laboratory parameters in the early stages of the development of a septic condition (the first 48 hours) in order to determine their relationship with the outcome of hospitalization.Results. All patients were divided into 2 groups. The first group (n=17, 42.5 %) consisted of patients with a favorable outcome of hospitalization (recovery), the second group (n=23, 57.5 %) consisted of patients with a fatal outcome. At the time of verification of sepsis, patients with a favorable outcome had a significantly lower SOFA score (3 (2; 6) points) than patients with a fatal outcome (6 (5; 7) points), p = 0.037. The change in urea concentration in the first 48 hours from the moment of verification of sepsis, which in the group of survivors was -1.3 (-4.4; 1.99) mmol/l, and in the group of deceased 5.5 (-1.5; 12. 2) mmol/l, p=0.020. In the group of deceased patients, 8 people (34 %) at the time of verification of sepsis had a combination of hypotension (<90/60 mm Hg) and serum lactate >5 mmol/l. In the survivor group, hypotension was observed in only 2 people (11 %), and lactate levels in these patients were in the range of 4.5- 4.6 mmol/l. At point 1, the indicators of immature granulocytes were not statistically significantly different between surviving and deceased patients (1.2 (0.7; 2.1)% vs 0.8 (0.6; 1.5)%, respectively, p>0. 05). After 48 hours, the level of immature granulocytes increased in surviving patients to 1.5 (1; 3.2)% and, conversely, decreased to 0.65 (0.45; 1.45)% in the group of deceased patients, and the difference in these indicators between groups became statistically significant, p <0.05.Conclusion. Thus, in patients with sepsis against the background of severe pneumonia, the mortality rate was 57.5 %. In order to identify groups at high risk of death due to sepsis due to pneumonia, in addition to the SOFA scale, dynamic monitoring of biomarkers such as urea, lactate, immature granulocytes and reticulocytes should be carried out in the first 48 hours from the moment of verification of the septic state.

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An effective and reliable marker in grading the severity of acute cholecystitis: increased immature granulocyte percentage

Cited by 2 publications

References 29 publications

The role of infectious parameters in the early prediction of complicated colonic diverticulitis

The role of infectious parameters in the early prediction of complicated colonic diverticulitis

Early Clinical and Laboratory Predictors of Hospital Mortality in Patients with Sepsis Secondary to Pneumonia

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