An ectopic approach for engineering a vascularized tracheal substitute

Tsao, Chung‐Kan; Ko, Chao-Yin; Yang, Shang‐Dong; Yang, Chan-Shan; Brey, Eric M.; Huang, Simon; Chu, I‐Ming; Cheng, Ming‐Huei

doi:10.1016/j.biomaterials.2013.10.055

Cited by 40 publications

(43 citation statements)

References 46 publications

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“…This task becomes more complicated when the target tissue is vascularized and composed of a hierarchical organization of heterogeneous tissues. Successful proof of the IVB principle has been shown for complex tissues such as the trachea (Tsao et al, 2014), full-thickness skin (Eriksson and Vranckx, 2004), bladder (Baumert et al, 2007b), esophagus (Badylak et al, 2011), and skeletal muscle (Bitto et al, 2013); and for organs such as the liver (Zhao et al, 2010), heart (Ott et al, 2008), and lung (Wu et al, 2013). However, the unmet clinical demands in these areas and the barriers to clinical translation in existing demonstrations are well known.…”

Section: Discussion: Future Trends and Challengesmentioning

confidence: 99%

Bone Graft Prefabrication Following the In Vivo Bioreactor Principle

Huang

Kobayashi

et al. 2016

EBioMedicine

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Large bone defect treatment represents a great challenge due to the difficulty of functional and esthetic reconstruction. Tissue-engineered bone grafts created by in vitro manipulation of bioscaffolds, seed cells, and growth factors have been considered potential treatments for bone defect reconstruction. However, a significant gap remains between experimental successes and clinical translation. An emerging strategy for bridging this gap is using the in vivo bioreactor principle and flap prefabrication techniques. This principle focuses on using the body as a bioreactor to cultivate the traditional triad (bioscaffolds, seed cells, and growth factors) and leveraging the body's self-regenerative capacity to regenerate new tissue. Additionally, flap prefabrication techniques allow the regenerated bone grafts to be transferred as prefabricated bone flaps for bone defect reconstruction. Such a strategy has been used successfully for reconstructing critical-sized bone defects in animal models and humans. Here, we highlight this concept and provide some perspective on how to translate current knowledge into clinical practice.

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Section: Discussion: Future Trends and Challengesmentioning

confidence: 99%

Bone Graft Prefabrication Following the In Vivo Bioreactor Principle

Huang

Kobayashi

et al. 2016

EBioMedicine

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“…PLGA–collagen scaffold was fabricated for tracheal tissue regeneration and had better mechanical strength but poor cartilage formation under in vivo (Tatekawa et al, ). Tsao et al () also fabricated PLGA scaffold by solvent casting method and seeded with chondrocytes and stem cells to enhance tissue regeneration. PLGA‐fabricated scaffold revealed deformation after 4 weeks with faster degradation (Tsao et al, ).…”

Section: Progress In Tracheal Tissue Engineeringmentioning

confidence: 99%

“…Tsao et al () also fabricated PLGA scaffold by solvent casting method and seeded with chondrocytes and stem cells to enhance tissue regeneration. PLGA‐fabricated scaffold revealed deformation after 4 weeks with faster degradation (Tsao et al, ).…”

Section: Progress In Tracheal Tissue Engineeringmentioning

confidence: 99%

Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

Dhasmana

Singh

2020

J Tissue Eng Regen Med

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Airway system is a vital part of the living being body. Trachea is the upper respiratory portion that connects nostril and lungs and has multiple functions such as breathing and entrapment of dust/pathogen particles. Tracheal reconstruction by artificial prosthesis, stents, and grafts are performed clinically for the repairing of damaged tissue. Although these (above-mentioned) methods repair the damaged parts, they have limited applicability like small area wounds and lack of functional tissue regeneration. Tissue engineering helps to overcome the abovementioned problems by modifying the traditional used stents and grafts, not only repair but also regenerate the damaged area to functional tissue. Bioengineered tracheal replacements are biocompatible, nontoxic, porous, and having 3D biomimetic ultrastructure with good mechanical strength, which results in faster and better tissue regeneration. Till date, the bioengineered tracheal replacements studies have been going on preclinical and clinical levels. Besides that, still many researchers are working at advance level to make extracellular matrix-based acellular, 3D printed, cell-seeded grafts including living cells to overcome the demand of tissue or organ and making the ready to use tracheal reconstructs for clinical application. Thus, in this review, we summarized the tracheal tissue engineering aspects and their outcomes. K E Y W O R D S biocompatible, chondrocytes, ECM, in vivo, tissue engineering, trachea

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“…The prefabricated groin flaps with skin substitutes provided a useful vehicle for the implantation of MSCs to serve as an autologous microvascular bioscaffold [25] . Poly(L-lactic-co-glycolic acid) or poly(ε-caprolactone) scaffolds seeded with co-cultured chondrocytes and BMSCs, were wrapped in a pedicle muscle flaps [26] .…”

Section: Mscs Therapy Against Pedicle Flaps Necrosismentioning

confidence: 99%

New advances in the mesenchymal stem cells therapy against skin flaps necrosis

Zhang¹

2014

WJSC

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Mesenchymal stem cells (MSCs), multipotential cells that reside within the bone marrow, can be induced to differentiate into various cells, such as osteoblasts, adipocytes, chondrocytes, vascular endothelial progenitor cells, and other cell types. MSCs are being widely studied as potential cell therapy agents due to their angiogenic properties, which have been well established by in vitro and in vivo researches. Within this context, MSCs therapy appears to hold substantial promise, particularly in the treatment of conditions involving skin grafts, pedicle flaps, as well as free flaps described in literatures. The purpose of this review is to report the new advances and mechanisms underlying MSCs therapy against skin flaps necrosis.

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An ectopic approach for engineering a vascularized tracheal substitute

Cited by 40 publications

References 46 publications

Bone Graft Prefabrication Following the In Vivo Bioreactor Principle

Bone Graft Prefabrication Following the In Vivo Bioreactor Principle

Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

New advances in the mesenchymal stem cells therapy against skin flaps necrosis

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