An ecofriendly and reusable catalyst RuO2/MWCNT in the green synthesis of sulfonyl-quinolines

Harikrishna, Singamsetty; Gangu, Kranthi Kumar; Robert, Alice R.; Ganja, Himavathi; Kerru, Nagaraju; Maddila, Suresh; Jonnalagadda, Sreekantha B.

doi:10.1016/j.psep.2022.01.054

Cited by 12 publications

(4 citation statements)

References 51 publications

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“…Furthermore, numerous sulfurcontaining fused quinolines, such as thieno quinolines, have received a lot of interest because of their biological activity [10,11]. We understood that there was a real need for the synthesis of a new quinoline ring system that would combine the five or six heterocyclic rings in light of these findings and in light of structural diversity, which plays a prominent role in medicinal and combinatorial chemistry and leads to a faster and more efficient lead generation in new drug discovery [12]. These chemicals might be useful in pharmacological research or creating novel medical products with unique features.…”

Section: Introductionmentioning

confidence: 99%

Quinolinecarbonitrile: Solvent‐free one‐pot synthesis, in vitro studies against leukemia cell lines, molecular docking, and potential Mcl‐1 inhibitors

Selim

Fadda

Tawfik

et al. 2022

Journal of Heterocyclic Chem

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In our study, we present an environmentally benign procedure for green synthesis of 4‐aryl/hetero aryl benzo[h]quinolin‐2‐one‐3‐carbonitrile. The synthesis protocol of quinolone carbonitrile derivatives, including the reaction of tetralone 1 and ethyl cyano acetate with hetero aryl and ammonium acetate under solvent‐free conditions, compounds 4a–i, 5, and 6, were obtained and its chemical structure was proved by different spectroscopic methods. The present synthetic approach could effectively produce different quinolone carbonitrile derivatives with high yields in the absence of solvent and in short reaction time, making it a green and sustainable process. All new compounds were screened for cytotoxicity on two kinds of acute lymphoblastic leukemia (ALL) cells, CRL‐2898, and MOLT‐4, and compared with normal human primary peripheral blood mononuclear cells PCS‐800‐011 using MTT assay. Compound 4g showed potent cytotoxicity with IC50 value 9.81, 9.81 μM against CRL‐2898 and MOLT‐4, respectively, without effect on normal cell. The most cytotoxic compounds 4g, 5, and 6 were docked into the active site of myeloid cell leukemia‐1(Mcl‐1). Compounds 4g and 6 showed strong hydrogen bond interaction with Arg263 through their carbonyl groups, achieving a binding mode similar to that of the native ligand.

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Section: Introductionmentioning

confidence: 99%

Quinolinecarbonitrile: Solvent‐free one‐pot synthesis, in vitro studies against leukemia cell lines, molecular docking, and potential Mcl‐1 inhibitors

Selim

Fadda

Tawfik

et al. 2022

Journal of Heterocyclic Chem

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“…Recently, Harikrishna et al . developed a method for the synthesis of RuO 2 /MWCNT nanocatalyst by simple technique [103] . This nanocatalyst was utilized in one‐pot, four‐component preparation of Sulfonyl hybrid quinoline scaffolds 230 (Scheme 63).…”

Section: Construction Of Quinoline Heterocyclesmentioning

confidence: 99%

“…Recently, Harikrishna et al developed a method for the synthesis of RuO 2 /MWCNT nanocatalyst by simple technique. [103] This nanocatalyst was utilized in one-pot, four-component preparation of Sulfonyl hybrid quinoline scaffolds 230 (Scheme 63). This reaction was occurred between dimedone 106, diverse aldehydes 227, NH 4 OAc 228 and phenylsulfonyl acetonitrile 229 in ethanolic condition.…”

Section: Chemistryselectmentioning

confidence: 99%

Recent Advances in Green Synthesis of Functionalized Quinolines of Medicinal Impact (2018‐Present)

Yadav

Bhalla

2022

ChemistrySelect

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The synthetic chemists are awakening to make substantial development in finding safer drugs against the rising communicable and non‐communicable type of diseases. By replacing traditional methods to more sustainable and greener approaches, multicomponent reactions are the rapid and efficient tool for the synthesis of organic molecules of structural diversity and complexity. Heterocyclic chemistry transforms small set of precursors into series of molecules by multicomponent domino reactions. This review covers recent trends of last five years (2018–2022) in construction of potentially drug‐like quinoline derivatives. The methods discussed here are preferable over conventional approaches being inexpensive, consuming lesser reaction time, atom economical, saving energy and manpower while avoiding toxic reagents/materials, chemical wastes and are environmental/occupational benign. The contributions covered here involve metallic, metal free strategies and other catalytic pathways including nanoparticles, ionic liquids and photocatalysis which are operationally safe and reliable.

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“…The heterogeneous catalysts proved economical and eco-friendly due to the effectiveness of non-hazardous metals for the construction of nanomaterials for atom-economical organic reactions [ 4 , 5 ]. Heterogeneous catalysts significantly affected scientific and industrial innovations due to their tuneable textural properties, flexible acid–base characteristics, higher thermal stability, and improved reusability, with their excellent performance over their enormous counterparts [ 6 , 7 , 8 , 9 , 10 , 11 ]. Due to the enhanced utility in academia and industries, these materials have received considerable attention in recent years as reusable catalysts to improve the rate of chemical transformation with excellent yields and create substantial routes [ 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Progress in the Multicomponent Synthesis of Pyran Derivatives by Sustainable Catalysts under Green Conditions

2022

Self Cite

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Pyrans are one of the most significant skeletons of oxygen-containing heterocyclic molecules, which exhibit a broad spectrum of medicinal applications and are constituents of diverse natural product analogues. Various biological applications of these pyran analogues contributed to the growth advances in these oxygen-containing molecules. Green one-pot methodologies for synthesising these heterocyclic molecules have received significant attention. This review focuses on the recent developments in synthesising pyran ring derivatives using reusable catalysts and emphasises the multicomponent reaction strategies using green protocols. The advantages of the catalysts in terms of yields, reaction conditions, and recyclability are discussed.

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An ecofriendly and reusable catalyst RuO2/MWCNT in the green synthesis of sulfonyl-quinolines

Cited by 12 publications

References 51 publications

Quinolinecarbonitrile: Solvent‐free one‐pot synthesis, in vitro studies against leukemia cell lines, molecular docking, and potential Mcl‐1 inhibitors

Quinolinecarbonitrile: Solvent‐free one‐pot synthesis, in vitro studies against leukemia cell lines, molecular docking, and potential Mcl‐1 inhibitors

Recent Advances in Green Synthesis of Functionalized Quinolines of Medicinal Impact (2018‐Present)

Recent Progress in the Multicomponent Synthesis of Pyran Derivatives by Sustainable Catalysts under Green Conditions

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