An Early Structured Psychoeducational Intervention in Patients With Breast Cancer

Capozzo, Maria Anna; Martinis, Elisabetta; Pellis, G.; Giraldi, Tullio

doi:10.1097/ncc.0b013e3181c1acd6

Cited by 25 publications

(22 citation statements)

References 30 publications

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“…In this connection, several studies showed that an increased anxious preoccupation, as determined with the Mini-MAC scale, was significantly associated with evidence of psychological stress symptoms, and appeared to be the most significant indicator of patients’ difficulties in mental adjustment to cancer 10,32–34. These findings are also in agreement with a feasibility study of psychosocial intervention in women with early breast cancer, which indicated high baseline values of anxious preoccupation HADS scores, which could be reduced by a psycho-educational intervention35 based on the approach originally devised by Fawzy and Fawzy for melanoma patients 36…”

Section: Discussionsupporting

confidence: 85%

5-HTTLPR polymorphism and anxious preoccupation in early breast cancer patients

Schillani¹,

Era²,

Cristante³

et al. 2012

Radiology and Oncology

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BackgroundDifficulties in coping with cancer, and the accompanying anxious and depressive symptoms, have been shown to affect the mood and the quality of life in breast cancer patients. 5-Hydroxytryptamine Transporter Gene-linked Polymorphic Region (5-HTTLPR) functional polymorphism of serotonin transporter has been shown to influence the adaptation to stressful life events. The aim of this prospective study was therefore to examine the association of 5-HTTLPR with the mental adaptation to cancer diagnosis and treatment.Patients and methodsForty eight consecutive patients with early mammary carcinoma were evaluated at enrolment and at follow up after one and three months. The patients were characterized psychometrically using the Hospital Anxiety and Depression Scale (HADS) and the Mini-Mental Adjustment to Cancer Scale (Mini-MAC); 5-HTTLPR allelic variants were determined using PCR-based techniques.ResultsIn women with early breast cancer, the mental adaptation to the disease was associated with high scores of avoidance and anxious preoccupation of Mini-MAC, which decreased with time at follow up. Anxious preoccupation decreased with time less in patients with the S/S and S/L genetic variant of 5-HTTLPR as compared with the L/L carriers (p=0.023), indicating gene - environment interactions.ConclusionsThese results indicate that the characterization of 5-HTTLPR allows the identification of breast cancer patients in greater risk of mental suffering, for which specific intervention may be focused; in case of drug therapy, they provide indications for the choice of most appropriate agent in a pharmacogenetic perspective.

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Section: Discussionsupporting

confidence: 85%

5-HTTLPR polymorphism and anxious preoccupation in early breast cancer patients

Schillani¹,

Era²,

Cristante³

et al. 2012

Radiology and Oncology

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“…Psycho-educational interventions show improvements in physical and psychosocial wellbeing [337] and reduced anxiety [338]. …”

Section: Resultsmentioning

confidence: 99%

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

et al. 2013

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IntroductionBreast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice.MethodsMore than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer ‘stem’ cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account.ResultsThe 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working.ConclusionsWith resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years.

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“…Components most commonly consisted are educational and psychological or psychosocial interventions (Pitceathly et al, 2009;Capozzo et al, 2010;Goerling et al, 2011;Lerman et al, 2011;Lurati et al, 2012). Due to complexity and individuality of psychological and physiological changes, researchers usually design their programs based on their own experiences and understandings.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the quality of life and psychological problems of cancer patients, an increasing number of psychological and psychosocial interventions have been in practice in recent years. Despite of debates whether psychological or psychosocial interventions could improve survival of cancer patients (Stefanek et al, 2009), randomized controlled studies proved benefits of psychological disorders relief and life quality improvement generally (Cameron et al, 2007;Pitceathly et al, 2009;Capozzo et al, 2010;Goerling et al, 2011;Lurati et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Perioperative Comprehensive Supportive Care Interventions for Chinese Patients with Esophageal Carcinoma: a Prospective Study

Zhang

Zhao²,

Fang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Objective: To assess the effects of perioperative comprehensive supportive care interventions on outcome of Chinese esophageal cancer patients in a prospective study. Methods: 60 patients with primary esophageal carcinoma were randomized into an intervention group (IG, n=31) and a control group (CG, n=29). The Chinese version of symptom checklist-90 (SCL-90) was adopted to assess their psychological status. The interventions, including health education, psychological support, stress management, coping strategies and behavior training, were carried out in 3 phases (preoperative, postoperative Ⅰ and postoperative Ⅱ), and psychological effects were thereafter evaluated accordingly before surgery, and 1 week, 4 weeks and 24 weeks post-surgery. Medical costs were estimated at discharge. Survival of patients was estimated each year post-surgery. General health status and satisfaction-with-hospital were surveyed by a follow-up questionnaire 4 years post-surgery. Results: All the subjects demonstrated higher scores in the preoperative phase than the normal range of Chinese population concerning 7 psychological domains including somatization, obsessive-compulsive, depression, anxiety, hostility, phobic anxiety and paranoid ideation. Although no significant difference was observed between the two groups at admission, the scores of IG, which tended to decrease at a faster rate, were generally lower than those of CG at weeks 1, 4 and 24 post-surgery. The length of hospital stay and medical costs of IG were significantly less than those of CG and satisfaction-with-hospital was better. However, there was no significant difference in 4-year survival or health status between two groups. Conclusions: Appropriate perioperative comprehensive supportive care interventions help to improve the psychological state of Chinese patients with esophageal carcinoma, to reduce health care costs and to promote satisfaction of patients and their families with hospital.

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An Early Structured Psychoeducational Intervention in Patients With Breast Cancer

Cited by 25 publications

References 30 publications

5-HTTLPR polymorphism and anxious preoccupation in early breast cancer patients

5-HTTLPR polymorphism and anxious preoccupation in early breast cancer patients

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

Perioperative Comprehensive Supportive Care Interventions for Chinese Patients with Esophageal Carcinoma: a Prospective Study

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