5-HTTLPR polymorphism and anxious preoccupation in early breast cancer patients

Schillani, Giulia; Era, Daniel; Cristante, Tania; Mustacchi, Giorgio; Richiardi, Martina; Grassi, Luigi; Giraldi, Tullio

doi:10.2478/v10019-012-0024-0

Cited by 16 publications

(15 citation statements)

References 42 publications

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“…We found in a previous study that the serotonin transport polymorphism HTTLPR was associated with nausea experienced by women up to a month following breast cancer surgery (Wesmiller et al, 2014). Those results were not replicated in this study; consistent with other researchers that have reported conflicting results with HTTLPR (Aapro et al, 2012; Grassi et al, 2010; Schillani et al, 2012). The DRD2 Taq1A polymorphism was not significant for association in this study.…”

Section: Discussionsupporting

confidence: 75%

Exploring the multifactorial nature of postoperative nausea and vomiting in women following surgery for breast cancer

Wesmiller

Sereika

Bender

et al. 2017

Autonomic Neuroscience

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Background Postoperative nausea and vomiting (PONV) are two of the most frequent and distressing complications following surgical procedures, with as many as 80% of patients considered to be at risk. Despite recognition of well-established risk factors and the subsequent use of clinical guidelines, 20–30% of women do not respond to antiemetic protocols, indicating that there may be a genetic risk. Objective The purpose of this pilot study was to describe the incidence and explore the risk factors associated with PONV after surgery in women diagnosed with early stage breast cancer. Methods A prospective cohort design was employed to measure PONV in women recruited prior to surgery. DNA was extracted from saliva samples collected prior to discharge. Polymorphisms for seven candidate genes with a known role in one of the neural pathways associated with PONV were included in this study; serotonin receptor (HTR3A), serotonin transport (SLC6A4), tryptophan (TPH), dopamine receptors (DRD2/ANKK and DRD3), catechol-O-methyltransferase (COMT) and histamine (H1). Results Twenty-nine (29.8%) women experienced nausea and 10 (11%) experienced nausea and vomiting while in the PACU despite administration of multiple antiemetic medications. Women who experienced PONV had higher levels of pain and received more opioids than those women who did not experienced PONV. Odds ratios demonstrated that alleles for the COMT, DRD3, and TPH genes were associated with decreased PONV. Conclusion The understanding of the multifactorial nature of PONV and the recognition of genetic risk will ultimately lead to the development of personalized interventions to manage these frequent and often debilitating symptoms.

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Section: Discussionsupporting

confidence: 75%

Exploring the multifactorial nature of postoperative nausea and vomiting in women following surgery for breast cancer

Wesmiller

Sereika

Bender

et al. 2017

Autonomic Neuroscience

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“…The 53 patients considered were initially subjected to psychometrical evaluation at recruitment (T0), and 35 of them (66%) were retested psychometrically at follow-up 3 months later (T1). When the scores of subscale employed determined at recruitment (T0) were stratified for age, employment, marital status, education, disease stage, treatment, and genotype, no significant differences were revealed (Schillani et al, 2012).…”

Section: Resultsmentioning

confidence: 93%

“…Mental adaptation to the disease was found to be associated with high scores of avoidance and anxious preoccupation, which spontaneously decreased with time at follow-up. A decrease of anxious preoccupation was significantly less pronounced in patients with the S/S and S/L genetic variant of 5-HTTLPR compared with the L/L carriers (Schillani et al, 2012).…”

Section: Introductionmentioning

confidence: 76%

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Mental Adaptation to Mammary Cancer and VNTR Genetic Polymorphism of MAO-A

Schillani

Jovic

Giraldi

2013

Neuropathol Diseases

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In women with early breast cancer, the carriers of the genetic polymorphism variants of serotonin transporter (5-HTTLPR) conferring low functional activity displayed high anxious preoccupation as mental adaptation to cancer (MAC) at follow-up. Therefore, we examined the role of the genetic polymorphism VNTR of monoamine oxidase-A (MAO-A) in the same patients. Mental adaptation to cancer was assessed using Mini-MAC scales at recruitment and at followup after 3 months. VNTR polymorphism of MAO-A was determined from blood or oral mucosa samples using conventional laboratory procedures. Women with the low-functionality activity MAO-A variant displayed significantly less anxious preoccupation at follow-up, as compared to the highly functional ones. No statistically significant effects of VNTR genotype and time were observed for the other subscales of Mini-MAC. The genotyping of women with early breast cancer for MAO-A VNTR, in addition and together to that for 5-HTTLPR, may allow the identification of the subjects that are likely to display a reduced reduction of their initial anxious preoccupation at follow-up. Interventions may be thus be aimed at the subjects in greater need of support. In the case of drug therapy, these results may allow the choice of the drug with the most appropriate mechanism of action and pharmacogenetic properties.

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“…It is said that certain genes may be responsible for the development of papillary thyroid carcinoma, such as the Forkhead box E1 (FOXE1) that has a negative impact [41]. Considering the following unpleasant cancer psychological experiences, Schillani et al have determined that 5-HTTLPR is a contributing factor to adverse emotions in breast cancer psychiatry [42]. In addition, post-traumatic stress disorder is a common and costly disease whose primary medical burden is related to cancer and is difficult to identify and manage [43].…”

Section: Post-traumatic Stress Disorder In Patients With Thyroid Cancermentioning

confidence: 99%

Progress in Research on 5-HTTLPR under Stress and Thyroid Papillary Carcinoma

Luo¹,

Guo²,

Chen³

et al. 2019

JBBS

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The central nervous system plays an important role in regulating thyroid hormone homeostasis. 5-HT is one of the important neurotransmitters involved in energy balance regulation. 5-HT transporters affect 5-HT function by regulating SERT protein expression and transcriptional activity. Based on the biological correlation between thyroid hormone and thyroid tumors, 5-HTTLPR is associated with thyroid tumors under stress. Animal models of thyroid disease have shown that some of the transmitters in the brain's monoaminergic nervous system have changed, and when the monoamine transporter gene expression is altered, it is found that this disorder is more pronounced. This article discusses whether thyroid papillary carcinoma patients are associated with 5-HTTLPR and whether the mechanism of thyroid papillary carcinoma "gene x environment" has an effect. Briefly describe the role of 5-HTTLPR in the development of patients with papillary thyroid carcinoma, and provide a basis for clinical diagnosis and treatment of papillary thyroid cancer.

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5-HTTLPR polymorphism and anxious preoccupation in early breast cancer patients

Cited by 16 publications

References 42 publications

Exploring the multifactorial nature of postoperative nausea and vomiting in women following surgery for breast cancer

Exploring the multifactorial nature of postoperative nausea and vomiting in women following surgery for breast cancer

Mental Adaptation to Mammary Cancer and VNTR Genetic Polymorphism of MAO-A

Progress in Research on 5-HTTLPR under Stress and Thyroid Papillary Carcinoma

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