An early fish oil-enriched diet reverses biochemical, liver and adipose tissue alterations in male offspring from maternal protein restriction in mice

Bringhenti, Isabele; Schultz, Alini; Rachid, Tamiris Lima; Bomfim, M. A. D.; Mandarim-de-Lacerda, Carlos Alberto; Águila, Márcia Barbosa

doi:10.1016/j.jnutbio.2010.08.013

Cited by 39 publications

(29 citation statements)

References 49 publications

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“…In rodents, an improvement in glucose homeostasis in offspring is observed if maternal LP-fed dams are given water supplemented with the amino acid taurine [122]. Supplementation with n-3 fatty acids or vitamin D during pregnancy has been another strategy explored in animal and human studies; however, results have been mixed and conclusions drawn remain controversial [123,124]. One study in humans showed that regular multivitamin use around the time of conception led to decreased risk of SGA births [125].…”

Section: Future Directions and Intervention Strategiesmentioning

confidence: 99%

Nutritional programming of insulin resistance: causes and consequences

Duque-Guimarães

Ozanne

2013

Trends in Endocrinology & Metabolism

123

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Section: Future Directions and Intervention Strategiesmentioning

confidence: 99%

Nutritional programming of insulin resistance: causes and consequences

Duque-Guimarães

Ozanne

2013

Trends in Endocrinology & Metabolism

123

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“…After weaning (postnatal day 21), the rats from the NLs were fed a soybean oil diet (dietary fat was soybean oil rich in u6 PUFAs; NL group) or a diet high in saturated fats (NL-HF group), and the rats from the SLs were fed a soybean oil diet (SL group), a diet high in saturated fat (SL-HF group), or a fish oil-rich diet (dietary fat was fish oil rich in u3 PUFAs; SL-FO group) until postnatal week 16 (W16). The diets (Slac, Shanghai, China) and their nutriment composition are shown in Table 1 (Note: the soybean oil diet was often referred to as 'standard chow' in previous studies (Reeves et al 1993, Bringhenti et al 2011). All animals were housed three per cage postweaning and fed ad libitum.…”

Section: Experimental Designmentioning

confidence: 99%

The effects of dietary fatty acid composition in the post-sucking period on metabolic alterations in adulthood: can ω3 polyunsaturated fatty acids prevent adverse programming outcomes?

Hou

Wang

et al. 2012

Journal of Endocrinology

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Early life nutrition is important in the regulation of metabolism in adulthood. We studied the effects of different fatty acid composition diets on adiposity measures, glucose tolerance, and peripheral glucocorticoid (GC) metabolism in overfed neonatal rats. Rat litters were adjusted to a litter size of three (small litters (SLs)) or ten (normal litters (NLs)) on postnatal day 3 to induce overfeeding or normal feeding respectively. After weaning, SL and NL rats were fed a u6 polyunsaturated fatty acid (PUFA) diet (14% calories as fat, soybean oil) or high-saturated fatty acid (high-fat; 31% calories as fat, lard) diet until postnatal week 16 respectively. SL rats were also divided into the third group fed a u3 PUFA diet (14% calories as fat, fish oil). A high-fat diet induced earlier and/or more pronounced weight gain, hyperphagia, glucose intolerance, and hyperlipidemia in SL rats compared with NL rats. In addition, a high-fat diet increased 11b-hsd1 (Hsd11b1) mRNA expression and activity in the retroperitoneal adipose tissue of both litter groups compared with standard chow counterparts, whereas high-fat feeding increased hepatic 11b-hsd1 mRNA expression and activity only in SL rats. SL and a high-fat diet exhibited significant interactions in both retroperitoneal adipose tissue and hepatic 11b-HSD1 activity. Dietary u3 PUFA offered protection against glucose intolerance and elevated GC exposure in the retroperitoneal adipose tissue and liver of SL rats. Taken together, the results suggest that dietary fatty acid composition in the post-sucking period may interact with neonatal feeding and codetermine metabolic alterations in adulthood.

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“…Venu et al 28 found that maternal Mg restriction increased pup plasma TC levels compared with control pups at 90 days. Bringhenti et al 35 found that low-protein diet increase serum TC levels in offspring at 3 month.…”

Section: Discussionmentioning

confidence: 99%

Maternal chromium restriction modulates miRNA profiles related to lipid metabolism disorder in mice offspring

Zhang

Xiao

Zheng

et al. 2017

Exp Biol Med (Maywood)

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Impact statementFor the first time, our study demonstrates important miRNA differences in the effect of maternal chromium restriction in offspring. These miRNAs may serve as ''bridges'' between the mother and the offspring by affecting the MAPK pathway. AbstractIncreasing evidence shows that maternal nutrition status has a vital effect on offspring susceptibility to obesity. MicroRNAs are related to lipid metabolism processes. This study aimed to evaluate whether maternal chromium restriction could affect miRNA expression involved in lipid metabolism in offspring. Weaning C57BL/6J mice born from mothers fed with normal control diet or chromium-restricted diet were fed for 13 weeks. The adipose miRNA expression profile was analyzed by miRNA array analysis. At 16 weeks old, pups from dams fed with chromium-restricted diet exhibit higher body weight, fat weight, and serum TC, TG levels. Six miRNAs were identified as upregulated in the RC group compared with the CC group, whereas eight miRNAs were lower than the threshold level set in the RC group. In the validated target genes of these differentially expressed miRNA, the MAPK signaling pathway serves an important role in the influence of early life chromium-restricted diet on lipid metabolism through miRNA. Long-term programming on various specific miRNA and MAPK signaling pathway may be involved in maternal chromium restriction in the adipose of female offspring.

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An early fish oil-enriched diet reverses biochemical, liver and adipose tissue alterations in male offspring from maternal protein restriction in mice

Cited by 39 publications

References 49 publications

Nutritional programming of insulin resistance: causes and consequences

Nutritional programming of insulin resistance: causes and consequences

The effects of dietary fatty acid composition in the post-sucking period on metabolic alterations in adulthood: can ω3 polyunsaturated fatty acids prevent adverse programming outcomes?

Maternal chromium restriction modulates miRNA profiles related to lipid metabolism disorder in mice offspring

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