2013
DOI: 10.1016/j.tem.2013.05.006
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Nutritional programming of insulin resistance: causes and consequences

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Cited by 123 publications
(92 citation statements)
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“…In any event, be it prenatally or postnatally, a high carbohydrate supply has been associated with alterations in insulin secretion, insulin resistance and impaired glucose metabolism often characterised by higher gluconeogenic output in adult mammals (Patel and Srinivasan, 2002;Patel et al, 2009). Analogous observations have been made in offspring following maternal protein restriction or intrauterine growth retardation, displaying glucose intolerance (Frantz et al, 2012;Duque-Guimarães and Ozanne, 2013;Kongsted et al, 2014), increased hepatic glucose output, reduced glucose phosphorylation (Desai et al, 1995;Ozanne et al, 1996) and altered glucose uptake by muscle skeletal cells as reflected by reduced Glut4 expression (Thamotharan et al, 2005;Devaskar and Thamotharan, 2007). In mammals, these are common signs of defects in glucose metabolism related to insulin resistance (AbdulGhani and DeFronzo, 2010).…”
mentioning
confidence: 68%
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“…In any event, be it prenatally or postnatally, a high carbohydrate supply has been associated with alterations in insulin secretion, insulin resistance and impaired glucose metabolism often characterised by higher gluconeogenic output in adult mammals (Patel and Srinivasan, 2002;Patel et al, 2009). Analogous observations have been made in offspring following maternal protein restriction or intrauterine growth retardation, displaying glucose intolerance (Frantz et al, 2012;Duque-Guimarães and Ozanne, 2013;Kongsted et al, 2014), increased hepatic glucose output, reduced glucose phosphorylation (Desai et al, 1995;Ozanne et al, 1996) and altered glucose uptake by muscle skeletal cells as reflected by reduced Glut4 expression (Thamotharan et al, 2005;Devaskar and Thamotharan, 2007). In mammals, these are common signs of defects in glucose metabolism related to insulin resistance (AbdulGhani and DeFronzo, 2010).…”
mentioning
confidence: 68%
“…Prenatal or early nutritional neonatal events exerted during critical developmental windows may result in permanent changes in postnatal growth potential, health and metabolic status in mammals (Burdge and Lillycrop, 2010;Lucas, 1998;Patel and Srinivasan, 2002;Patel et al, 2009;Metges et al, 2014;Duque-Guimarães and Ozanne, 2013;Devaskar and Thamotharan, 2007). It has been RESEARCH ARTICLE 1 INRA, UR1067 Nutrition Metabolism and Aquaculture, F-64310 Saint-Pée-surNivelle, France.…”
Section: Introductionmentioning
confidence: 99%
“…In the aggregate, in-depth studies have established that adverse pre- and postnatal environments have significant long-term effects on the risk of insulin resistance later in life [3]. The importance of healthy dietary choices is highlighted by the worrying trends for childhood obesity, which can be improved not only through improving the lifestyle of the children but also that of the parents.…”
Section: Discussionmentioning
confidence: 99%
“…It has been known for some time that dietary factors can influence the risk of insulin resistance, and in recent years it has come to light that this risk can be transmitted to offspring through intrauterine reprogramming events. Additionally, nutrition during early life has been shown to influence the development of metabolic diseases later in life [3]. Currently, management of type 2 diabetes (T2D) entails lifestyle changes, use of oral hypoglycemic agents, and injectable insulin.…”
Section: Introductionmentioning
confidence: 99%
“…Several lines of evidence in both human and rodent studies support the concept that nutritional status during early development, including embryonic and fetal as well as early postnatal periods, programs metabolism and propensity to gain weight later in life (13)(14)(15)(16)(17)(18)(19). For example, in a historical cohort study, exposure to the Dutch famine of 1944-1945 during the fi rst half of pregnancy is associated with increased obesity rates in early adulthood, while exposure during the last trimester and the fi rst months of life is associated with reduced obesity rates ( 20 ).…”
Section: Real-time Quantitative Pcr Analysismentioning
confidence: 96%