An Autopsy Case Report of Malignant Pleural Mesothelioma with Deciduoid Features

Abstract

Deciduoid mesothelioma is a rare variant of epithelioid mesothelioma. We experienced the case of a 73-year-old man with asbestos exposure who was diagnosed with malignant pleural mesothelioma with deciduoid features. He received chemotherapy containing six cycles of cisplatin and pemetrexed and survived for twenty-five months after the diagnosis. At autopsy, the final diagnosis was biphasic pleural mesothelioma. Cells with deciduoid features had mostly disappeared, and spindle cells markedly proliferated. To the best of our knowledge, this is the first autopsy case of malignant pleural mesothelioma with deciduoid features that exhibited a response to chemotherapy. Case ReportA 73-year-old man visited our hospital with sudden onset dyspnea and left chest pain. He quit a 40 pack-years smoking habit at 63 years of age when he received pancreatoduodenectomy for an adenocarcinoma of the major duodenal papilla. He also had a history of asbestos exposure when he worked as a shipyard worker until retirement. A chest X-ray examination revealed a collapse of the left lung. Subsequent computed tomography of the chest revealed the collapse of the left lung, diffuse distribution of a low attenuation area in both lungs and trivial thickening at the dorsal region of the left parietal pleura, leading to a diagnosis of secondary spontaneous pneumothorax. During partial lobectomy under video-assisted thoracic surgery for the continuous air leakage with catheter

Deciduoid mesothelioma of the thorax: A comprehensive review of the scientific literature

“…Forty‐four cases included in 16 articles, published in the period under investigation, were analyzed in detail . The description of two cases was included in two different articles; demographic and clinical information was retrieved from both articles .…”

Malignant Deciduoid Mesothelioma: case presentation of an exceptional variant and review of the literature

“…Histologically, there are four major subtypes of mesothelioma: epithelioid, sarcomatoid, desmoplastic and biphasic. Deciduoide mesothelioma is a rare subtype of epithelioid mesothelioma, in which a wide range of histopathological patterns is described [18, 19]. …”

“…Microscopically, deciduoid mesothelioma is composed of large, polygonal, or round cells, arranged in solid nests and in trabecula [13, 18, 19]. The cytoplasm is abundant eosinophilic with well-defined cell borders [18, 19].…”

“…The cytoplasm is abundant eosinophilic with well-defined cell borders [18, 19]. The nuclei is large and vesicular, with prominent nucleoli.…”