An Autopsy Case of Congenital Goiter

Okayasu, Isao; Mori, Wataru; Miyagawa, Noboru

doi:10.1111/j.1440-1827.1973.tb01222.x

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Iodide goiters in human adults are induced by prolonged intake of "coast goiter" patients in Hokkaido, Japan, is estimated as 200 mg/day (56). Prolonged excess iodine intake of pregnant mothers places newborns at risk of iodide goiter (39,49,56). The amount of daily dietary iodine intake from all sources is therefore clearly an important factor affecting human health.…”

Section: Introductionmentioning

confidence: 99%

Tumor-Promoting Effects of Both Iodine Deficiency and Iodine Excess in the Rat Thyroid

et al. 1992

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A B S T R A~Thyroid tumor-promoting effects of iodine deficiency and iodine excess were investigated in a rodent 2-stage model to estimate an optimal iodine intake range that would not effectively promote development of thyroid neoplasia. Six-week-old male F344 rats were given a single subcutaneous injection of 2,800 mg/ kg body weight N-bis(2-hydroxypropyI)-nitrosamine (DHPN) or saline vehicle, maintained on Remington's iodine-deficient diet (21 k 2 ng/g iodide), and supplemented with various amounts of potassium iodide up to 260 mg/liter in drinking water to generate conditions ranging from severe iodine deficiency to severe iodine excess. In DHPN-treated rats, both conditions significantly increased thyroid follicular tumorigenesis. In DHPN-untreated rats, iodine deficiency produced diffuse thyroid hyperplasia, characterized by small follicles with tall epithelium and reduced colloid, together with a decrease in thyroxine (T4) and an increase in thyroid-stimulating hormone (TSH). On the other hand, iodine excess produced colloid goiter, characterized by large follicles with flat epithelium and abundant colloid admixed with normal or small-sized follicles lined by cpithelium of normal height, together with normal serum T4 and slightly decreased TSH. These effects were directly proportional to the severity of iodine deficiency or extent of iodine excess and suggest that each condition has a different thyroid tumor promotion mechanism. Iodine intakes that showed the least tumor promotion were 2.6 and 9.7 pg/rat/day in this study. Promoting mechanisms and the problem of statistically estimating recommended daily iodine intake range are briefly discussed.

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Section: Introductionmentioning

confidence: 99%

Tumor-Promoting Effects of Both Iodine Deficiency and Iodine Excess in the Rat Thyroid

et al. 1992

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Adverse Reactions to Iodide Therapy of Asthma and Other Pulmonary Diseases

Yaffe¹,

Bierman²,

Cann³

et al. 1976

Pediatrics

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Neonatal deaths from tracheal obstruction caused by congenital goiters have been reported from such widely scattered locales as Buffalo, New York, New York City, Philadelphia, Washington, D.C., Seattle, Tokyo, Japan, and Glasgow, Scotland. The mothers of these infants had asthma and were receiving conventional doses of iodides, either as potassium iodide or as mixtures of bronchodilators and iodides. Because of these deaths, the Committee on Drugs of the American Academy of Pediatrics has reviewed the use of iodides in the therapy of asthma and other chronic pulmonary diseases. Five current textbooks advocate the use of iodides in chronic asthma.1-5 "Iodide compounds have a stimulating effect on bronchial secretions and represent expectorants of major importance in treating asthma and particularly status asthmaticus."2 The AMA Drug Evaluations6 recommends the use of iodides only for short-term medication. Current Pediatric Therapy7 emphasizes careful patient selection because only an occasional patient may benefit. Dosage recommendations usually are 300 mg of potassium iodide every two hours in adults1 and 60 mg per year of age four times daily in children.4 These dosage recommendations are many times greater than the 65 mg of organic iodine (T4 and T3) which the average human thyroid gland delivers to the circulation per day, or the estimated daily adult iodide requirement of 200 mg of iodide.8 As a matter of fact, these recommended dosages for iodides represent 10 to 30 times the total body content of iodide! Many preparations–some of which are available on an over-the-counter (nonprescription) basis–contain iodides, including antiasthmatic preparations, expectorants, and preparations whose trade names may not suggest the presence of iodides.

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An Autopsy Case of Congenital Goiter

Cited by 2 publications

References 12 publications

Tumor-Promoting Effects of Both Iodine Deficiency and Iodine Excess in the Rat Thyroid

Tumor-Promoting Effects of Both Iodine Deficiency and Iodine Excess in the Rat Thyroid

Adverse Reactions to Iodide Therapy of Asthma and Other Pulmonary Diseases

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