Tumor-Promoting Effects of Both Iodine Deficiency and Iodine Excess in the Rat Thyroid

Kanno, Jun; Oda, Hiroshi; Furuta, Kyoko; Maekawa, Akihiko; Kasuga, Tsutomu; Hayashi, Yuzo

doi:10.1177/019262339202000209

Cited by 76 publications

(40 citation statements)

References 44 publications

(37 reference statements)

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“…The precise factors that might explain the suggested risk of thyroid cancer associated with fish consumption have not been precisely determined, although dietary iodine is probably involved (Williams et al, 1977;Kanno et al, 1992). Iodine intake is probably higher in the northern parts of Norway, and an estimation of the intake based on consumption of fish and milk from 1983 to 1985 suggests a ratio of 1.5 between northern Norway and east Norway (K Lund-Larsen, personal communication).…”

Section: Discussionmentioning

confidence: 99%

Increased risk of thyroid cancer among Norwegian women married to fishery workers – a retrospective cohort study

Frich

Akslen²,

Glattre³

1997

Br J Cancer

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Summary The relationship between thyroid cancer in women and the occupation of their spouses was examined in a retrospective cohort study, with special reference to fishery. Of the 2.9 million women registered in the Central Population Registry of Norway on 31 December 1991, 1.2 million women had a spouse registered with an occupation in one or more of the censuses in 1960, 1970 or 1980. The women were assigned to ten broad categories based on the first digit of their husbands five-digit Nordic occupational classification code NYK, and a standardized incidence ratio (SIR) was calculated for each occupational category. The women were further subdivided and analysed in 71 groups defined by the first two digits of the NYK code. Among the women included in the study, a total of 2409 cases of thyroid cancer were reported to the cancer registry of Norway during 1960-92. A significantly elevated risk of thyroid cancer was found only among women whose spouses belonged to the occupational category 'agriculture, forestry or fishery' (n = 208 279), with a SIR of 1.13. In the group associated with 'fishing, whaling and sealing work' (n = 40 839), the risk was further increased (SIR 1.91, Cl 1.65-2.21). An increased risk was also detected in the group associated with 'ship officers and pilots work' (n= 29 133) (SIR 1.35, Cl 1.07-1.67). When allocating the women to southern and northern cohorts determined by their county of birth, a difference in risk was clearly present in all 10 occupational categories, with figures being 50-60% higher in the north. However, there was practically no difference in incidence between northern and southern cohorts among women associated with fishery work. Thus, the results obtained from this study indicate that being a fisherman's wife is associated with elevated risk of thyroid cancer, and our data support the suggested role of seafood as an aetiological factor.

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Section: Discussionmentioning

confidence: 99%

Increased risk of thyroid cancer among Norwegian women married to fishery workers – a retrospective cohort study

Frich

Akslen²,

Glattre³

1997

Br J Cancer

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“…In animal experiments J. Kanno et al (28) have shown that iodine in the diet contributes to the occurrence of thyroid neoplasia in a special way. The curve showing the percentage of rats with lesions is bimodal with one peak in the low range of iodine intake, that is approximately 1-10 µg/rat/day, and one in the range from around 1000 µg/rat/day and upwards.…”

Section: Viewpoints On Thyroid Carcinogenesismentioning

confidence: 99%

The Norwegian Thyroid Cancer Project: History, achievements and present view on carcinogenesis

Glattre¹

2011

Nor J Epidemiol

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The Norwegian Thyroid Cancer Project was established in 1985. Its crew has consisted of an interdisciplinary group of scientists, and its secretariat has been part of the Cancer Registry of Norway since day 1. The aim has been to describe the occurrence of thyroid cancer in Norway, investigate etiological aspects and publish results. Focus has been on the papillary carcinoma of the thyroid, the most incident type of thyroid neoplasia in Norway. Important results of the Project are briefly mentioned. Some forty publications have been produced, mostly epidemiological analyses, but also some experimental studies. The results of the Project and of others have led to the acknowledgement that thyroid carcinogenesis is a complexity-phenomenon partly inaccessible to common scientific procedure. NORSK SAMMENDRAGCancer thyreoidea prosjektet kom igang i 1985. De forskere som har arbeidet innenfor prosjektet, har hatt forskjellig faglig bakgrunn. Prosjektsekretariatet har ligget i Kreftregisteret helt fra starten av. Målsetningen har hele tiden vaert å beskrive opptredenen av skjoldkjertelkreft i Norge samt gjøre etiologiske undersøkelser. Fokus har vaert på det papillaere carcinom som er det hyppigste her til lands. En del viktige forskningsresultater blir kort omtalt. Det er produsert ca. 40 publikasjoner i regi av Prosjektet, den overveiende del er epidemiologiske analyser, i tillegg noen dyreeksperimenter. De samlede erfaringene har ført til den erkjennelse at thyreoidea-karsinogenesen er et kompleksfenomen som bare delvis er tilgjengelig for vitenskapelig forskning.

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“…According to epidemiological, clinical and experimental studies, both the dietary deficiency and excess of iodine have been associated with increased risk of thyroid carcinomas [5][6][7][8] . In this connection, the effect of salt water fish and shellfish consumption as a measure of iodine exposure has been discussed [9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Effect of long-term administration of arsenic (III) and bromine with and without selenium and iodine supplementation on the element level in the thyroid of rat

Kotyzová¹,

Eybl²,

Mihaljevič³

et al. 2005

BIOMED PAP

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The aim of this study was to evaluate the influence of arsenic and bromine exposure with or withour iodine and selenium supplementation on the element level in the thyroid of rats. Four major groups of Wistar female rats were fed with respective diets: group A -standard diet, group B -iodine rich diet (10 mg I/kg food), group C -selenium rich diet (1 mg Se/kg) and group D -iodine and selenium rich diet (as in group B and C). Each group was divided into four subgroups per 7 animals each receiving either NaAsO 2 ip (6.5 mg.kg -1 twice a week for two weeks and 3.25 mg.kg -1 for six weeks) or KBr in drinking water (58.8 mg.l -1 ) for 8 weeks or combined administration of both substances. Remaining subgroup served as controls. After 8 weeks thyroid glands were analyzed by ICP-MS for As, Br, Se, and I content. The exposition of rat to arsenic or bromine causes the accumulation of these elements in the thyroid gland (∼18 ppm of As, ∼90 ppm of Br) and significantly affects iodine and selenium concentration in the thyroid. In iodine and/or selenium supplemented rats the bromine intake into the thyroid was lowered to ∼50% of the level in unsupplemented animals. Also selenium thyroid level elevated due to KBr administration was lowered by iodine supplementation in the diet. The accumulation of arsenic in the thyroid was not influenced by selenium or iodine supplementation; however, As(III) administration increased iodine thyroid level and suppressed selenium thyroid level in selenium or iodine supplemented group of animals.

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Tumor-Promoting Effects of Both Iodine Deficiency and Iodine Excess in the Rat Thyroid

Cited by 76 publications

References 44 publications

Increased risk of thyroid cancer among Norwegian women married to fishery workers – a retrospective cohort study

Increased risk of thyroid cancer among Norwegian women married to fishery workers – a retrospective cohort study

The Norwegian Thyroid Cancer Project: History, achievements and present view on carcinogenesis

Effect of long-term administration of arsenic (III) and bromine with and without selenium and iodine supplementation on the element level in the thyroid of rat

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