An Autonomous and Controllable Light‐Driven DNA Walking Device

You, Mingxu; Chen, Yan; Zhang, Xiaobing; Liu, Haipeng; Wang, Ruowen; Wang, Kelong; Williams, Kathryn R.; Tan, Weihong

doi:10.1002/anie.201107733

Cited by 191 publications

(166 citation statements)

References 37 publications

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“…24 These dynamic DNA functional units exhibit good performance and have been used in the construction of DNA walkers, 5 tweezers, 6 logic circuits, 7–9 gene regulators 10–12 and smart therapeutics. 13,14 Most recently, bioengineering has focused on DNA nanostructures on the cell surface, resulting in the design of many nanostructures and devices interacting with the cell membrane.…”

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confidence: 99%

Facile Assembly/Disassembly of DNA Nanostructures Anchored on Cell-Mimicking Giant Vesicles

et al. 2017

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DNA nanostructures assembled on living cell membranes have become powerful research tools. Synthetic lipid membranes have been used as a membrane model to study the dynamic behavior of DNA nanostructures on fluid soft lipid bilayers, but without the inherent complexity of natural membranes. Herein, we report the assembly and disassembly of DNA nanoprisms on cell-mimicking micrometer-scale giant membrane vesicles derived from living mammalian cells. Three-dimensional DNA nanoprisms with a DNA arm and a cholesterol anchor were efficiently localized on the membrane surface. The assembly and disassembly of DNA nanoprisms were dynamically manipulated by DNA strand hybridization and toehold-mediated strand displacement. Furthermore, the heterogeneity of reversible assembly/disassembly of DNA nanoprisms was monitored by Förster resonance energy transfer. This study suggests the feasibility of DNA-mediated functional biomolecular assembly on cell membranes for biomimetics studies and delivery systems.

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Facile Assembly/Disassembly of DNA Nanostructures Anchored on Cell-Mimicking Giant Vesicles

et al. 2017

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“…391 This walking system consists of three parts: a single-stranded DNA track (black), four anchorage strands (blue), and a light-sensitive walker (red). The DNA walker contains two motion legs, a shorter leg (7 nucleotides) and a longer leg (16 nucleotide), and they are linked by pyrene moieties (green) that work as photosensitizer.…”

Section: Determination Of Dna Nanostructures In Solutionsmentioning

confidence: 99%

Chemistry Can Make Strict and Fuzzy Controls for Bio-Systems: DNA Nanoarchitectonics and Cell-Macromolecular Nanoarchitectonics

Komiyama

Yoshimoto

Sisido

et al. 2017

Bulletin of the Chemical Society of Japan

268

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In this review, we introduce two kinds of bio-related nanoarchitectonics, DNA nanoarchitectonics and cellmacromolecular nanoarchitectonics, both of which are basically controlled by chemical strategies. The former DNA-based approach would represent the precise nature of the nanoarchitectonics based on the strict or "digital" molecular recognition between nucleic bases. This part includes functionalization of single DNAs by chemical means, modification of the main-chain or side-chain bases to achieve stronger DNA binding, DNA aptamers and DNAzymes. It also includes programmable assemblies of DNAs (DNA Origami) and their applications for delivery of drugs to target sites in vivo, sensing in vivo, and selective labeling of biomaterials in cells and in animals. In contrast to the digital molecular recognition between nucleic bases, cell membrane assemblies and their interaction with macromolecules are achieved through rather generic and "analog" interactions such as hydrophobic effects and electrostatic forces. This cell-macromolecular nanoarchitectonics is discussed in the latter part of this review. This part includes bottom-up and top-down approaches for constructing highly organized cell-architectures with macromolecules, for regulating cell adhesion pattern and their functions in twodimension, for generating three-dimensional cell architectures on micro-patterned surfaces, and for building synthetic/natural macromolecular modified hybrid biointerfaces.

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“…In der Angewandten Chemie wurde ein Artikel von ihm über einen lichtgetriebenen DNA-Läufer verçf-fentlicht. [3] Heinrich …”

Section: Florida Award Für Weihong Tanunclassified

NAS Award in Chemical Sciences: T. J. Marks / Richard C. Tolman Award: K. O. Christe / Florida Award: W. Tan / Heinrich‐Emanuel‐Merck‐Preis: A. R. Wheeler

2012

Angewandte Chemie

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An Autonomous and Controllable Light‐Driven DNA Walking Device

Cited by 191 publications

References 37 publications

Facile Assembly/Disassembly of DNA Nanostructures Anchored on Cell-Mimicking Giant Vesicles

Facile Assembly/Disassembly of DNA Nanostructures Anchored on Cell-Mimicking Giant Vesicles

Chemistry Can Make Strict and Fuzzy Controls for Bio-Systems: DNA Nanoarchitectonics and Cell-Macromolecular Nanoarchitectonics

NAS Award in Chemical Sciences: T. J. Marks / Richard C. Tolman Award: K. O. Christe / Florida Award: W. Tan / Heinrich‐Emanuel‐Merck‐Preis: A. R. Wheeler

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