“…This fact has spurred innovation in many high-throughput screening areas in the past few years, much of which has not yet appeared in the literature but has inundated the patent and trademark office. Some of the leading examples that have been published, in addition to crystallization, are solubility measurements ,− and chemical reaction and degradation kinetics. − More recently, high-throughput homogeneous and heterogeneous catalyst screening, which has been impacting the chemical industry for years, has begun to permeate the pharmaceutical arena. − Catalytic reactions can be extremely challenging on a small scale because of the very small amounts of catalyst required and sensitivity of the reactions to environmental and reaction parameters (e.g., mixing, pressure, temperature, oxygen and moisture in the air, etc.). This is especially true for heterogeneous catalytic hydrogenations because the reaction mixture exists as three physical phases.…”