An automated amidolytic assay for testing factor X activity

Aiach, Martine; Schreiber, Nicole B.; Nussas, C; Michaud, Anne; Léon, Martine; Leclerc, Marie

doi:10.1016/0049-3848(81)90169-9

Cited by 11 publications

(9 citation statements)

References 3 publications

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“…The assay of functional Factor VII or Factor X (or Factor Xa) can easily be performed by fully automated techniques using synthetic substrates. 4,169 This includes both chromogenic and fluorogenic substrate techniques, which lend themselves to semiautomation or full automation. Both disorders are inherited as autosomal recessive traits and both manifest similar clinical bleeding diatheses.…”

Section: Rarer Congenital Coagulationmentioning

confidence: 99%

Clinical Hemostasis Practice: The Major Impact of Laboratory Automation

Bick¹

1983

Semin Thromb Hemost

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This article has reviewed basic disease states of hemostasis and thrombosis with an emphasis on laboratory technologic advances comparing manual and semiautomated techniques with new fully automated technology that is now available for both aiding in a diagnosis and monitoring efficacy of therapy. As these new automated methods become generally available, more and more information will be accumulated to determine exactly how precise many of these modalities will be for diagnosis and monitoring. Many of these newer modalities have already gained general acceptance as highly sophisticated tools that certainly belong in any clinical laboratory having to deal with patients with thrombohemorrhagic disorders.

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Section: Rarer Congenital Coagulationmentioning

confidence: 99%

Clinical Hemostasis Practice: The Major Impact of Laboratory Automation

Bick¹

1983

Semin Thromb Hemost

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“…Having achieved significant success in the area of plasminogen, antithrombin III, heparin and α 2antiplasmin assays, research biochemists and coagulationists turned their attention to individual zymogens and have now automatable assays for prekallikrein, 9 Factor VIII, 27 Factor V, 16,21 Factor VII, 4 Factor X, 2 and prothrombin. 5 In addition, progress has been made toward automatable global chromogenic substrate assays to replace or supple ment the prothrombin time 3 and activated partial thromboplastin time, 3 and a new automatable clotting method has been reported.…”

Section: Historical Perspectivementioning

confidence: 99%

Automation in Coagulation Testing Clinical Applications

Messmore¹

1983

Semin Thromb Hemost

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“…Similar in operation to the ABA-100 is the Isamat from ISA-Biologie (Cachan, France). Aiach and co-workers 2,3,86 have reported on assays applied to the Isamat which give reliable diagnostic values for Factor X, heparin, and AT III levels.…”

Section: Lal Proenzyme Enzymementioning

confidence: 99%