An attractive way of egg white protein by-product use for producing of novel anti-hypertensive peptides

Pokora, Marta; Zambrowicz, Aleksandra; Dąbrowska, Anna; Eckert, Ewelina; Setner, Bartosz; Szołtysik, Marek; Szewczuk, Zbigniew; Zabłocka, Agnieszka; Polanowski, Antoni; Trziszka, Tadeusz; Chrzanowska, Józefa

doi:10.1016/j.foodchem.2013.11.111

Cited by 34 publications

(15 citation statements)

References 16 publications

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“…Thus, hydrolysis of egg white protein will reduce molecular weight and allergenicity, and its function will also be improved. Moreover, the hydrolysates are easier to digest, and they also possess angiotensin I‐converting enzyme (ACE) inhibitory action and display antioxidant and other biological activity …”

Section: Introductionmentioning

confidence: 99%

Enzymatic characterisation of the immobilised Alcalase to hydrolyse egg white protein for potential allergenicity reduction

et al. 2016

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Section: Introductionmentioning

confidence: 99%

Enzymatic characterisation of the immobilised Alcalase to hydrolyse egg white protein for potential allergenicity reduction

et al. 2016

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“…Whey proteins are significantly resistant to hydrolysis and the use of enzymes significantly increases the cost of their production. One of the promising alternatives is the use of plant serine protease isolated from C. ficifolia, exhibiting attractive proteolytic properties towards casein, protein from corn gluten meal (CGM) or ovoalbumin (Illanes et al 1985 ; Curotto et al 1989 ; Pokora et al 2014 ). The protease exhibits a very high and broad pH optimum with a maximum at 10.7 and is able to cleave four bonds in an endogenous serine proteinase inhibitor.…”

Section: Introductionmentioning

confidence: 99%

The Evaluation of Dipeptidyl Peptidase (DPP)-IV, α-Glucosidase and Angiotensin Converting Enzyme (ACE) Inhibitory Activities of Whey Proteins Hydrolyzed with Serine Protease Isolated from Asian Pumpkin (Cucurbita ficifolia)

Babij

Dąbrowska

Szołtysik

et al. 2014

Int J Pept Res Ther

107

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In the present study, whey protein concentrate (WPC-80) and β-lactoglobulin were hydrolyzed with a noncommercial serine protease isolated from Asian pumpkin (Cucurbita ficifolia). Hydrolysates were further fractionated by ultrafiltration using membranes with cut-offs equal 3 and 10 kDa. Peptide fractions of molecular weight lower than 3 and 3–10 kDa were further subjected to the RP-HPLC. Separated preparations were investigated for their potential as the natural inhibitors of dipeptidyl peptidase (DPP-IV), α-glucosidase and angiotensin converting enzyme (ACE). WPC-80 hydrolysate showed higher inhibitory activities against the three tested enzymes than β-lactoglobulin hydrolysate. Especially high biological activities were exhibited by peptide fractions of molecular weight lower than 3 kDa, with ACE IC50 <0.64 mg/mL and DPP-IV IC50 <0.55 mg/mL. This study suggests that peptides generated from whey proteins may support postprandial glycemia regulation and blood pressure maintenance, and could be used as functional food ingredients in the diet of patients with type 2 diabetes.

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“…Large amounts of protein-rich waste and bioactive nitrogenous compounds have extensively been generated every year. The major waste and by-products generated in the agro-industrial activity comprise microalgae [ 75 , 76 ], soybean meal [ 77 ], residues of olive production [ 78 ], rapeseed meal [ 79 ], chicken feathers [ 80 ], fish waste [ 81 ] and egg protein [ 82 ]. In particular, this waste is proteinaceous in nature and includes proteins, peptides and amino acids.…”

Section: Obtaining Peptides From Agro-industrial Wastementioning

confidence: 99%

A Review of the Latest Advances in Encrypted Bioactive Peptides from Protein-Rich Waste

Lemes

Sala

Ores

et al. 2016

IJMS

189

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Bioactive peptides are considered the new generation of biologically active regulators that not only prevent the mechanism of oxidation and microbial degradation in foods but also enhanced the treatment of various diseases and disorders, thus increasing quality of life. This review article emphasizes recent advances in bioactive peptide technology, such as: (i) new strategies for transforming bioactive peptides from residual waste into added-value products; (ii) nanotechnology for the encapsulation, protection and release of controlled peptides; and (iii) use of techniques of large-scale recovery and purification of peptides aiming at future applications to pharmaceutical and food industries.

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An attractive way of egg white protein by-product use for producing of novel anti-hypertensive peptides

Cited by 34 publications

References 16 publications

Enzymatic characterisation of the immobilised Alcalase to hydrolyse egg white protein for potential allergenicity reduction

Enzymatic characterisation of the immobilised Alcalase to hydrolyse egg white protein for potential allergenicity reduction

The Evaluation of Dipeptidyl Peptidase (DPP)-IV, α-Glucosidase and Angiotensin Converting Enzyme (ACE) Inhibitory Activities of Whey Proteins Hydrolyzed with Serine Protease Isolated from Asian Pumpkin (Cucurbita ficifolia)

A Review of the Latest Advances in Encrypted Bioactive Peptides from Protein-Rich Waste

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