“…In the current study, the AUC of the classifier with the best performance was 0.86. Previous studies reported highest AUC values ranging between from 0.80 to 0.89 in classifying AD vs. controls (Babiloni et al, 2016; Chai et al, 2019; Chedid et al, 2022; de Haan et al, 2008; Ding et al, 2022; Fernández et al, 2006; Meghdadi et al, 2021; Trambaiolli et al, 2011), and between 0.60 and 0.81 in classifying MCI vs. controls (Ding et al, 2022; Gómez et al, 2009; Meghdadi et al, 2021; Sibilano et al, 2023). Considering that those studies investigated disease stages of AD with apparent cognitive impairments, our model achieved similar classification performance in a preclinical phase of AD with normal cognition.…”