Personalized modeling of neurodegeneration determines dementia severity from EEG recordings
L.G. Amato,
A. A. Vergani,
M. Lassi
et al.
Abstract:INTRODUCTIONEarly identification of dementia is necessary for a timely onset of therapeutic care. However, cortical structural alterations associated with early dementia are difficult to disclose. METHODS: We developed a cortical model of dementia-related neurodegeneration accounting for slowing of local dynamics and global connectivity degradation. We collected EEG recordings at rest from subjects in healthy (HC), Subjective Cognitive Decline (SCD), and Mild Cognitive Impairment (MCI) condition. For each pati… Show more
INTRODUCTION. Subjective cognitive decline (SCD), mild cognitive impairment (MCI), or severe Alzheimer's disease stages are still lacking clear electrophysiological correlates. METHODS. In 145 subjects (86 SCD, 40 MCI, and 19 healthy subjects (HS)), we analysed event-related potentials observed during a sustained visual attention task, aiming to distinguish biomarkers associated with group conditions and performance. RESULTS. We observed distinct patterns among group conditions in the occipital P1 and N1 components during the stimulus encoding phase, as well as in the central P3 component during the stimulus decision phase. The order of ERP components was non-monotonic, indicating a closer resemblance between MCI and HS. ERP features from occipital channels exhibited greater differences between SCD and MCI. Task performance was significantly enhanced in the central channels during the decision phase. DISCUSSION. Those results support evidence of early stage, neural anomalies linked to visuo-attentive alterations in cognitive decline as candidate EEG biomarkers.
INTRODUCTION. Subjective cognitive decline (SCD), mild cognitive impairment (MCI), or severe Alzheimer's disease stages are still lacking clear electrophysiological correlates. METHODS. In 145 subjects (86 SCD, 40 MCI, and 19 healthy subjects (HS)), we analysed event-related potentials observed during a sustained visual attention task, aiming to distinguish biomarkers associated with group conditions and performance. RESULTS. We observed distinct patterns among group conditions in the occipital P1 and N1 components during the stimulus encoding phase, as well as in the central P3 component during the stimulus decision phase. The order of ERP components was non-monotonic, indicating a closer resemblance between MCI and HS. ERP features from occipital channels exhibited greater differences between SCD and MCI. Task performance was significantly enhanced in the central channels during the decision phase. DISCUSSION. Those results support evidence of early stage, neural anomalies linked to visuo-attentive alterations in cognitive decline as candidate EEG biomarkers.
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