An attempt to treat patients who have injured spinal cords with intralesional implantation of concentrated autologous bone marrow cells

Stem cell based therapies for spinal cord injury

“…Sasaki et al (2001) found that bone marrow mesenchymal stem cells can be used to repair spinal axons and myelin sheath. Attar et al (2011) used bone marrow mesenchymal stem cells in clinical trial and none of the patients showed adverse reactions. In the year 2000, Zuk and Safford et al (Zuk, 2001;Safford et al, 2002) extracted adipose derived mesenchymal stem cells and proved that it can be differentiated into neurons in vivo.…”

“…Since then several authors reported that iPSCs can be differentiated into neural cells and glial cells and applied in the treatment of mice, rat and monkey spinal cord injury models (Tsuji et al, 2010;Kimura et al, 2005;Attar et al, 2011). Puri and Nagy (2012) compared ESs and iPSCs and found that they have similar morphological, functional and genetic characteristics.…”

Advances in stem cell therapy for spinal cord injury

“…There are other reports of small numbers of patients treated with MSC transplants showing no adverse effects (103,104). Collectively, evidence suggests that even transient MSC engraftment may exert favorable effects through secretion of cytokines and other paracrine factors that engage and recruit recipient cells in tissue repair (105).…”

Standards for the culture and quality control of umbilical cord mesenchymal stromal cells for neurorestorative clinical application (2017)

“…12,13 A large number of preclinical and clinical repair studies have been performed on various systemic diseases, including neurologic disorders and damage. [14][15][16][17][18][19][20][21][22][23][24] But to date, there have been no standardized guidelines for the culture and quality control of MSCs in the neurorestorative clinical application. In order to ensure the safety and effectiveness of clinical application of this type of cells, it is important to standardize the cell culture and quality control processes.…”