Standards for the culture and quality control of umbilical cord mesenchymal stromal cells for neurorestorative clinical application (2017)

Ao, Qiang; Yu, Yanqiu; Mao, Gengsheng; Zou, Qingyan; Gao, Wenyong; Huang, Hongyun

doi:10.2147/jn.s148686

Cited by 2 publications

(2 citation statements)

References 22 publications

(20 reference statements)

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“…The multifactorial properties of MSCs may be advantageous in this regard. MSCs can regulate inflammatory responses, have a good capacity to donate mitochondria, and are able to secrete trophic factors; these properties may underlie the popular use of MSCs for treatment of different indications that include SCI [ 114 , 115 ]. In vitro and in vivo studies showed that MSCs seem to be able to alleviate the secondary injury caused by inflammation [ 116 ], restore myelin insulation, promote axonal regeneration, and assist in angiogenesis [ 117 – 121 ].…”

Section: Mitochondria-based Therapy In Treatment Of Neurological Dmentioning

confidence: 99%

Mesenchymal Stem/Stromal Cell-Mediated Mitochondrial Transfer and the Therapeutic Potential in Treatment of Neurological Diseases

Han

Zheng

Wang

et al. 2020

Stem Cells International

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Mesenchymal stem/stromal cells (MSCs) are multipotent stem cells that can be derived from various tissues. Due to their regenerative and immunomodulatory properties, MSCs have been extensively researched and tested for treatment of different diseases/indications. One mechanism that MSCs exert functions is through the transfer of mitochondria, a key player involved in many biological processes in health and disease. Mitochondria transfer is bidirectional and has an impact on both donor and recipient cells. In this review, we discussed how MSC-mediated mitochondrial transfer may affect cellular metabolism, survival, proliferation, and differentiation; how this process influences inflammatory processes; and what is the molecular machinery that mediates mitochondrial transfer. In the end, we summarized recent advances in preclinical research and clinical trials for the treatment of stroke and spinal cord injury, through application of MSCs and/or MSC-derived mitochondria.

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Section: Mitochondria-based Therapy In Treatment Of Neurological Dmentioning

confidence: 99%

Mesenchymal Stem/Stromal Cell-Mediated Mitochondrial Transfer and the Therapeutic Potential in Treatment of Neurological Diseases

Han

Zheng

Wang

et al. 2020

Stem Cells International

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“…(2) MSC must express CD105, CD73 and CD90, and lack expression of CD45, CD34, CD14 or CD11b, CD79alpha or CD19 and HLA-DR surface molecules; and (3) MSC must differentiate to osteoblasts, adipocytes and chondroblasts in vitro [65][66][67].…”

Section: Guidelinesmentioning

confidence: 99%

2018 Yearbook of Neurorestoratology

Huang¹,

Sharma

Lin

et al. 2019

Journal of Neurorestoratology

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The Neurorestoratology discipline is getting worldwide attention from the clinicians, basic scientists, students and policy makers alike. Accordingly, this year too, the discipline has made profound advances and great achievements for the benefit of the mankind. In this report, of the 2018 Neurorestoratology Yearbook, salient features of new developments are summarized. This Yearbook consists 3 key themes namely (i) the new findings on pathogenesis of neurological diseases or degeneration; (ii) the new mechanisms of neurorestorative aspects; and (iii) the achievements and progresses made in the clinical field of neurorestorative therapies. The new trend has emerged in clinical studies that are based on greater levels of evidence-based medical practices both in clinical therapies and clinical trials based on standard designs.

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Standards for the culture and quality control of umbilical cord mesenchymal stromal cells for neurorestorative clinical application (2017)

Cited by 2 publications

References 22 publications

Mesenchymal Stem/Stromal Cell-Mediated Mitochondrial Transfer and the Therapeutic Potential in Treatment of Neurological Diseases

Mesenchymal Stem/Stromal Cell-Mediated Mitochondrial Transfer and the Therapeutic Potential in Treatment of Neurological Diseases

2018 Yearbook of Neurorestoratology

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