An attempt to diagnose cancer by PIXE

Uda, M.; Maeda, Kuniko; Sasa, Y.; Kusuyama, Hiroko; Yokode, Yutaka

doi:10.1016/0168-583x(87)90322-3

Cited by 23 publications

(4 citation statements)

References 4 publications

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“…While comparing their observation with another study which also studied trace elements in thyroid, both studies established consistent concentrations of K, Ca, and I, while variations were observed in the concentration of Cu, Zn, and Fe in cancerous thyroid compared to noncancerous tissues [36, 37]. Zn concentration in adenoma and cancerous thyroid was found to be lower than that in normal tissues, an observation consistent with other findings in the study of kidney and hair samples, respectively [38, 39]. Zn deficiency has been linked to severe deficiency in immune function and disruption in T-Cell function which is directly related to pathogenic carcinoma.…”

Section: Trace Metal Concentrations In Human Tissuessupporting

confidence: 84%

Comparative Trace Elemental Analysis in Cancerous and Noncancerous Human Tissues Using PIXE

Mulware

2013

Journal of Biophysics

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The effect of high or low levels of trace metals in human tissues has been studied widely. There have been detectable significant variations in the concentrations of trace metals in normal and cancerous tissues suggesting that these variations could be a causative factor to various cancers. Even though essential trace metals play an important role such as stabilizers, enzyme cofactors, elements of structure, and essential elements for normal hormonal functions, their imbalanced toxic effects contribute to the rate of the reactive oxygen species (ROS) and formation of complexities in the body cells which may lead to DNA damage. The induction of oxidative-induced DNA damage by ROS may lead to isolated base lesions or single-strand breaks, complex lesions like double-strand breaks, and some oxidative generated clustered DNA lesions (OCDLs) which are linked to cell apoptosis and mutagenesis. The difference in published works on the level of variations of trace metals in different cancer tissues can be attributed to the accuracy of the analytical techniques, sample preparation methods, and inability of taking uniform samples from the affected tissues. This paper reviews comparative trace elemental concentrations of cancerous and noncancerous tissues using PIXE that has been reported in the published literature.

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Section: Trace Metal Concentrations In Human Tissuessupporting

confidence: 84%

Comparative Trace Elemental Analysis in Cancerous and Noncancerous Human Tissues Using PIXE

Mulware

2013

Journal of Biophysics

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“…On the other hand, it is well known that either an excess or a defi ciency of certain trace metals can lead to biological disorders. Uda et al observed that the defi ciency or excess of trace elements concentrations in cancerous tissues of different organs may be different (11). In the literature, it is described that trace element concentrations of healthy adult thyroid glands were not dependent on sex or age (12).…”

Section: Discussionmentioning

confidence: 99%

Serum copper levels in benign and malignant thyroid diseases

Kosova

Çetin²,

Akıncı³

et al. 2012

BLL

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Abstract:Objective: To examine the changes in serum copper (Cu) levels in benign and malignant thyroid disease in humans. Background: Thyroid hormones infl uence the metabolism of trace elements including copper. Methods: 47 papillary thyroid cancer and 43 benign multinodular goitre patients who underwent total thyroidectomy and 37 healthy control subjects were included into this study. All of the patients and controls were females. Serum Cu levels were detected with atomic absorption spectrophotometer. Results: In the papillary thyroid cancer group serum level of Cu was 131.61±33.9 μg/dL before surgery and 120.81±30.4 μg/dL after 20 days from surgery. In the benign group serum Cu level was 84.75±12.1 μg/dL and 68.01±9.4 μg/dL postoperatively.These results were compared to healthy control's value of 105.87±10.68 μg/dL. In the papillary thyroid cancer group pre-and postoperative serum Cu level was signifi cantly higher when compared to control group (p<0.05). Postoperative serum Cu level signifi cantly decreased when compared to pre-operative level(p<0.05), in which, it was still higher than the control(p<0.05). In the benign group pre-and postoperative serum Cu level was significantly lower than in the control group (p<0.05).Postoperative serum Cu level signifi cantly decreased when compared to pre-operative level in the benign group (p<0.05). Conclusion: This is a pioneer study to examine serum Cu level in benign and malignant thyroid patients compared to controls. In our small groups serum Cu levels increased in malignant thyroid patients and decreased in the benign group (Tab. 1, Ref. 18 Trace elements are essential micro-nutrients both for humans and other organisms. They are crucial for many physiological processes and are involved in many pathologic changes in tissues (1). Thyroid hormones infl uence the metabolism of trace elements including copper (Cu) (2). Cu is important for the activity of the enzyme superoxide dismutase (SOD). Changes in the activity of this enzyme are consistent with the Cu serum levels (3). Cu was shown to be essential for cell division both in normal and cancerous tissue (4, 5). Although copper is an essential element for human and animals, a high concentration of Cu (above normal) could induce growth proliferation and cancer by damaging DNA with toxic free hydroxyl radicals (6).The present study was undertaken to investigate correlation of Cu serum levels in benign and malign thyroid diseases before and after surgery compared to controls. Materials and methodsThis is an age-and sex-matched case-control study, conducted at the Department of Medical Biochemistry of Celal Bayar University of Medicine and the Department of General Surgery of Ankara Oncology Hospital, Ankara, Turkey. The study was approved by the hospital Ethical committee. All the patients and the volunteers involved in the study have given informed consent. PatientsRecruitment of subjects was performed by convenience sampling at outpatient General Surgery Clinic of Oncology Hospital, Turkey by trained physicians. 47...

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“…Depending on the proton energy and sample composition, detection limits may be as low as pg/g. Several investigations on biological samples have been based on PIXE experiments. − …”

Section: X-ray Fluorescence Spectroscopy and Trace Elementsmentioning

confidence: 99%