An Atom-economic Efficient Synthesis of 1-Amidoalkyl-2-naphthols Mediated By Hexachlorocyclotriphosphazene (HCCP) as a Novel Catalyst

Abstract

A multicomponent one-pot atom-economic reaction is performed for an efficient synthesis of 1-amidoalkyl-2-naphthol from aromatic aldehydes, β-naphthol and amide/urea promoted by hexachlorocyclotriphosphazene (HCCP). Various techniques such as stirring, microwave irradiation and thermal technique (hot plate and oil bath) were used in different solvents for the synthesis of 1- amidoalkyl-2-naphthol derivatives with moderate to excellent yield. Among the four methods, microwave irradiation and oil bath heating provide high yield as compared to the hot plate heating and stirring method. The low yield may be due to the formation of undesired side-products due to non-uniform heating.

Synthesis, Docking Study and Biological Activities Evaluation of 1‐Amidoalkyl‐2‐naphthol Derivatives as Dual Inhibitors of Cholinesterase and α‐Glucosidase

“…From the literature review it is noted that many procedures are described, in the presence of Brønsted or Lewis acid catalysts [8] such as p-toluenesulfonic acid, [9] oxalic acid, [10] Montmorillonite K10, [11] NaHSO 4 .H 2 O, [12] Fe (HSO 4 ) 3 , [13] saccharin sulfonic acid, [14] P 2 O 5 , [15] β-cyclodextrinbutane sulfonic acid [16] and hexachlorocyclotriphosphazene. [17] The use of nanoparticles such as Ni NPs, [18] MNPs-PhSO 3 H, [19] AgI NPs, [20] ZnO NPs, [21] Ba 2 (PO 4 ) 2 nanopowders [22] and Nano magnetite Fe 3 O 4 [23] has been also reported. In addition, the synthesis of 1-amidoalkyl-2-naphthols has been extended to the use of ionic liquids, [24] heteropolyacids [25] and supported catalysts.…”

ZnO nanorods as efficient catalyst for the green synthesis of thiophene derivatives: Investigation of antioxidant and antimicrobial activity

“…In the field of catalysis, one optimization factor is the development of the use of nanocatalysts . The high yields and good selectivity of some organic reactions occur with nanocatalysts compared with the normal‐sized forms . This is due to enhanced catalytic activity of nanocatalysts, resulting from increased surface area .…”

“…[17] The high yields and good selectivity of some organic reactions occur with nanocatalysts compared with the normalsized forms. [18][19][20][21][22][23][24][25][26][27][28] This is due to enhanced catalytic activity of nanocatalysts, resulting from increased surface area. [29,30] In recent years, metal oxides, because of their acid-base and redox properties, are the chief kinds of heterogeneous catalysts.…”