Green and one-pot synthesis of novel amidoalkyl naphthols using triethanolammonium acetate [(OHCH2CH2)3NH][OAc]) ionic liquid and their anti-H.pylori activity

Amidoalkyl Naphthols as Important Bioactive Substances and Building Blocks: A Review on the Current Catalytic Mannich-Type Synthetic Approaches

“…However, the results from the antifungal test were very promising, since five substances (compounds 6-10, Figure 3) exhibited better potencies against Aspergillus niger than the standard drugs fluconazole and miconazole. Another study by Manavi et al, revealed the in vitro anti-Helicobacter pylori activities of various amidoalkyl naphthols [20]. The obtained results illustrated that many of them show promising potency with compound 11 (Figure 4) being the most active against this bacteria.…”

“…The results indicated that compounds 12-18 (Figure 5) were the most potent against Staphylococcus aureus, exhibiting better activity than the reference, gentamicin. Another study by Manavi et al, revealed the in vitro anti-Helicobacter pylori activities of various amidoalkyl naphthols [20]. The obtained results illustrated that many of them show promising potency with compound 11 (Figure 4) being the most active against this bacteria.…”

“…The 1-amidoalkyl-2-naphthols possess diverse biological properties, such as antiviral, antibacterial, antifungal, and antiparasitic qualities [18][19][20][21][22]. Furthermore, members of this family are promising antioxidants, which also show cholinesterase and α-glucosidase inhibitory activities [23][24][25].…”

“…Manavi et al, utilized triethanolammonium acetate ionic liquid as a green and reusable catalyst for solvent-free synthesis of a series of compounds, using 2-naphthol, (hetero)aromatic aldehydes, and urea/acetamide at 90 • C. Although relatively high catalyst loading of 20 mol% was required, the authors successfully prepared the targeted derivatives in moderate to high yields of 76 to 91% in up to 85 min reaction times. Furthermore, the synthesized products were tested for in vitro anti-Helicobacter pylori activity and it was found that they exhibited promising potency [20].…”