We examine the relationship between coronal hole evolution and solar active regions during the Skylab period. We find a tendency for holes to grow or remain stable when the activity nearby, seen as calcium plages and bright regions in X-rays, is predominantly large, long-lived regions. This is consistent with results of previous studies, using somewhat different methods. We also find that there is a significantly higher number of small, short-lived active regions, as indicated by X-ray bright points, in the vicinity of decaying holes than there is near other holes. We interpret this to mean that holes disappear at least in part because they become filled with many small scale, magnetically closed, X-ray emitting features. This interpretation, together with the previously reported observation that the number of X-ray bright points was much larger near solar minimum than it was during the Skylab period, provides a possible explanation for the disappearance of the large, near-equatorial coronal holes at the time of solar minimum.