An Association Study on Renalase Polymorphisms and Ischemic Stroke in a Chinese Population

Zhang, Ruyou; Li, Xiaoying; Liu, Nana; Guo, Xijuan; Liu, Wei; Ning, Chunping; Wang, Zhenzhen; Sun, Lei; Fu, Songbin

doi:10.1007/s12017-013-8227-0

Cited by 34 publications

(30 citation statements)

References 27 publications

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“…Similar results were obtained with a different cohort, a northern Chinese Han population [26]. In 507 ischemic stroke patients and 503 sexmatched controls, rs10887800 and rs2576178 SNPs were significantly associated with ischemic stroke and hypertension.…”

Section: Disease Association With Renalase Single Nucleotide Polymorpsupporting

confidence: 83%

Renalase

Guo

Wang

Velázquez

et al. 2014

Current Opinion in Nephrology and Hypertension

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Purpose of review Remarkable progress has been achieved over the past 2 years in understanding the cellular actions of renalase, its pathophysiology and potential therapeutic utility. Recent findings There has been a paradigm shift in our thinking about the mechanisms underlying the cellular actions of renalase. We now understand that, independent of its enzymatic properties, renalase functions as a signaling molecule, a cytokine that interacts with a yet-to-be identified plasma membrane receptor(s) to activate protein kinase B and the mitogen-activated protein kinase pathway. These signaling properties are critical to its cytoprotective effects. New information regarding renalase’s enzymatic function as an α-nicotinamide adenine dinucleotide oxidase/anomerase will be reviewed. Lastly, we will discuss the association of certain single nucleotide polymorphisms in the renalase gene with type 1 diabetes and with ischemic stroke, and the clinical implications of these findings. Summary The consistent association of renalase single nucleotide polymorphisms and the development of type 1 diabetes is a great interest particularly because we now understand that renalase functions as a cytokine. Future work on renalase should focus on exploring the identity of its receptor(s), and its potential role as an immune modulator.

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Section: Disease Association With Renalase Single Nucleotide Polymorpsupporting

confidence: 83%

Renalase

Guo

Wang

Velázquez

et al. 2014

Current Opinion in Nephrology and Hypertension

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“…Renalase gene has been found to be involved in the regulation of blood pressure [15]. Further studies reveal that renalase is closely associated with hypertension, myocardial ischemia [12], acute kidney injury [16], diseases related to organ transplantation [17,18,19], heart dysfunction [20,21], ischemic stroke [9,22] and diabetes [23,24]. The two SNPs of renalase gene (rs2576178 and rs229654) have been found to be related to hypertension [8].…”

Section: Discussionmentioning

confidence: 99%

Renalase Gene Polymorphism in Patients with Hypertension and Concomitant Coronary Heart Disease

Jiang

et al. 2014

Kidney Blood Press Res

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Background/Aims: This study aimed to investigate renalase gene polymorphism in patients with hypertension and concomitant coronary heart disease (CHD) and to evaluate the risk for CHD in hypertensive patients from the view of genetics. Methods: NCBI and HapMap genome database were employed to screen the Single nucleotide polymorphisms (SNP). These SNPs were detected in hypertensive and CHD patients (n=791), hypertensive patients (n=802) and healthy controls (n=812), and the genotypes were recorded. Haploview 4.2 software was used to determine the genotypes, allele frequency, haplotypes, linkage disequilibrium and Hardy-Weinberg (HWE) equilibrium, and odds ratio (OR) was calculated with non-conditioned logistic regression analysis. Results: The frequency of allele A of rs2576178 in patients with hypertensive and CHD was markedly higher than that in hypertensive patients (p=0.001, OR=1.625,95% CI 1.221-2.160). The frequency of allele C of rs2296545 in hypertensive patients was significantly higher than that in healthy controls (P=0.009, OR=1.436, 95% CI 1.095-1.883). Conclusion: The allele A of rs2576178 may be a predisposing factor of CHD in hypertensive patients, and hypertensive patients with AA genotype are susceptible to develop CHD. The allele C of rs2296545 may be a predisposing factor of hypertension and patients with CC genotype are susceptible to develop hypertension.

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“…Thus, additional evidence is needed to confirm whether renalase is an amine oxidase. Renalase deficiency has been reportedly associated with chronic kidney disease, heart disease, diabetes, stroke, and hypertension [9,10,11,12]. …”

Section: Introductionmentioning

confidence: 99%

Effects of Renin-Angiotensin System Inhibitors on Renal Expression of Renalase in Sprague-Dawley Rats Fed With High Salt Diet

Wang

Xie

Gao³

et al. 2015

Kidney Blood Press Res

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Background/Aims: The aim of our study was to investigate the effect of high-salt diet on the renal expression of renalase and the potential role of the local renin-angiotensin system in this process. Methods: Sprague-Dawley (SD) rats were divided into groups according to salt content in diet and drug treatment as follows: normal-salt diet (NS), high-salt diet (HS), high-salt intake with hydralazine (HS+H), high-salt diet with enalapril (HS+E), and high-salt diet with valsartan (HS+V). The dietary intervention and drugs were given for four weeks. Renin activity and angiotensin II type 1 receptor (AT1R) levels were detected by real-time PCR. Renalase mRNA and protein were also measured. Results: After four weeks, systolic blood pressure and proteinuria were significantly increased in the HS group with respect to the NS group. Dietary salt intake caused a dramatic decrease in renalase expression in the rat kidneys. Renal cortex renin and AT1R increased significantly in the HS and HS+H groups. Urinary protein was positively correlated with renal renin and AT1R levels. However, in the HS+E and HS+V groups, enalapril and valsartan failed to influence renal renalase expression but abolished the increase in proteinuria, renal cortex renin, and AT1R levels with respect to the HS group. Conclusion: This study indicates that high salt intake reduces renal expression, and renal RAS may be not involved in the regulation of renalase in SD rats fed with high-salt diet.

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An Association Study on Renalase Polymorphisms and Ischemic Stroke in a Chinese Population

Cited by 34 publications

References 27 publications

Renalase

Renalase

Renalase Gene Polymorphism in Patients with Hypertension and Concomitant Coronary Heart Disease

Effects of Renin-Angiotensin System Inhibitors on Renal Expression of Renalase in Sprague-Dawley Rats Fed With High Salt Diet

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