An association between serum testosterone level and HLA phenotype

Are there common human leucocyte antigen associations in juvenile idiopathic arthritis and periodontitis?

“…These results confirmed the relationship between HLA-DRB3 n and female gender and the role of HLA-DRB3 n as a risk indicator for JIA and periodontitis revealed in the present study. The revealed gender-specific HLA associations in periodontitis (for instance, no HLA associations among periodontitis males) could be caused by a relationship between the serum level of sex hormones and the HLA phenotype (Gerencer et al 1982). Genderspecific HLA associations were also shown for rheumatic diseases such as Reiter's disease, ankylosing spondylitis, acute anterior uveitis, and psoriatic arthritis (James 1991), for leukaemia (Dorak et al 1995), and mixed forms of psoriasis vulgaris and atopic dermatitis (Stepanova et al 2004).…”

Possible constraints on adaptive variation in sex ratio at birth in humans and other primates

“…I suggest that one reason for this is that a risk factor for this disease is HLA B8 (e.g. Turner et al, 2000;Verkasalo et al, 1983) and that HLA B8 is reportedly associated with low testosterone levels in women (Gerencer et al, 1982). Ex hypothesi, the low sex ratio is due to the mothers' low testosterone level.…”

An Mhc Component to Kin Recognition and Mate Choice in Birds: Predictions, Progress, and Prospects

“…In addition, it is likely that the adaptive immune response and the action of Mhc genes are influenced directly or indirectly by circulating hormones such as testosterone or corticosterone (Hillgarth and Wingfield 1997). For example, testosterone induces the proliferation of certain T cell populations in male chickens (Arstila and Lassila 1993), and, conversely, Mhc type can influence serum testosterone levels in mammals (Gerencer et al 1982;Larsen et al 2000). Thus Mhc genes are best viewed as important defenses against parasites that modulate and are modulated by diverse biological systems.…”