An Association Between Serum Amylase Phenotype and Tick Infestation in Cattle

Ashton, G. C.; Seifert, GW; Francis, J

doi:10.1071/bi9680303

Cited by 12 publications

(7 citation statements)

References 5 publications

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“…Numerous studies have attempted to identify genetic markers for host resistance to tick infestation and they are summarized and discussed by Porto Neto et al ( 2011b ) and Mapholi et al ( 2014 ). Approaches have included immunological methods (Stear et al, 1984 , 1989 , 1990 ); protein-based analyses (Ashton et al, 1968 ; Carvalho et al, 2008 ); candidate gene sequence or genotype (Acosta-Rodriguez et al, 2005 ; Martinez et al, 2006 ; Untalan et al, 2007 ); genomic detection of quantitative trait loci (QTL) using SNPs or microsatellites, with or without fine mapping (Barendse, 2007 ; Gasparin et al, 2007 ; Regitano et al, 2008 ; Prayaga et al, 2009 ; Machado et al, 2010 ; Porto Neto et al, 2010a , 2011a ; Turner et al, 2010 ; Cardoso et al, 2015 ; Mapholi et al, 2016 ; Sollero et al, 2017 ). There is one example of a meta-analysis of genomic association with transcriptome in tick infestation (Porto Neto et al, 2010b ).…”

Section: Molecular Genetic Variants Associated With Host Resistancementioning

confidence: 99%

Cattle Tick Rhipicephalus microplus-Host Interface: A Review of Resistant and Susceptible Host Responses

Tabor

Ali

Rehman

et al. 2017

Front. Cell. Infect. Microbiol.

102

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Ticks are able to transmit tick-borne infectious agents to vertebrate hosts which cause major constraints to public and livestock health. The costs associated with mortality, relapse, treatments, and decreased production yields are economically significant. Ticks adapted to a hematophagous existence after the vertebrate hemostatic system evolved into a multi-layered defense system against foreign invasion (pathogens and ectoparasites), blood loss, and immune responses. Subsequently, ticks evolved by developing an ability to suppress the vertebrate host immune system with a devastating impact particularly for exotic and crossbred cattle. Host genetics defines the immune responsiveness against ticks and tick-borne pathogens. To gain an insight into the naturally acquired resistant and susceptible cattle breed against ticks, studies have been conducted comparing the incidence of tick infestation on bovine hosts from divergent genetic backgrounds. It is well-documented that purebred and crossbred Bos taurus indicus cattle are more resistant to ticks and tick-borne pathogens compared to purebred European Bos taurus taurus cattle. Genetic studies identifying Quantitative Trait Loci markers using microsatellites and SNPs have been inconsistent with very low percentages relating phenotypic variation with tick infestation. Several skin gene expression and immunological studies have been undertaken using different breeds, different samples (peripheral blood, skin with tick feeding), infestation protocols and geographic environments. Susceptible breeds were commonly found to be associated with the increased expression of toll like receptors, MHC Class II, calcium binding proteins, and complement factors with an increased presence of neutrophils in the skin following tick feeding. Resistant breeds had higher levels of T cells present in the skin prior to tick infestation and thus seem to respond to ticks more efficiently. The skin of resistant breeds also contained higher numbers of eosinophils, mast cells and basophils with up-regulated proteases, cathepsins, keratins, collagens and extracellular matrix proteins in response to feeding ticks. Here we review immunological and molecular determinants that explore the cattle tick Rhipicephalus microplus-host resistance phenomenon as well as contemplating new insights and future directions to study tick resistance and susceptibility, in order to facilitate interventions for tick control.

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Section: Molecular Genetic Variants Associated With Host Resistancementioning

confidence: 99%

Cattle Tick Rhipicephalus microplus-Host Interface: A Review of Resistant and Susceptible Host Responses

Tabor

Ali

Rehman

et al. 2017

Front. Cell. Infect. Microbiol.

102

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“…Ashton et al. (1968) found an association between serum amylase phenotype, which is located on BTA3, and tick infestation in cattle.…”

Section: Resultsmentioning

confidence: 96%

Mapping of quantitative trait loci controlling tick [Riphicephalus (Boophilus) microplus] resistance on bovine chromosomes 5, 7 and 14

et al. 2007

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Differences in domestication and selection processes have contributed to considerable phenotypic and genotypic differences between Bos taurus and Bos indicus cattle breeds. Of particular interest in tropical and subtropical production environments are those genetic differences between subspecies that underlie the phenotypic extremes in tolerance and susceptibility to parasite infection. In general, B. taurus cattle are more susceptible to ectoparasites than B. indicus cattle in tropical environments, and much of this difference is under genetic control. To identify genomic regions involved in tick resistance, we developed a B. taurus x B. indicus F(2) experimental population to map quantitative trait loci (QTL) for resistance to the Riphicephalus (Boophilus) microplus tick. About 300 individuals were measured for parasite load in two seasons (rainy and dry) and genotyped for 23 microsatellite markers covering chromosomes 5, 7 and 14. We mapped a suggestive chromosome-wide QTL for tick load in the rainy season (P < 0.05) on chromosome 5. For the dry season, suggestive (P < 0.10) chromosome-wide QTL were mapped on chromosomes 7 and 14. The additive effect of the QTL on chromosome 14 corresponds to 3.18% of the total observed phenotypic variance. Our QTL-mapping study has identified different genomic regions controlling tick resistance; these QTL were dependent upon the season in which the ticks were counted, suggesting that the QTL in question may depend on environmental factors.

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Section: Markers and Haplotypes Most Significantly Associated With Tmentioning

confidence: 99%

“…The first association was to the serum amylase locus on bovine chromosome (BTA) 3 (Ashton et al 1968). The first association was to the serum amylase locus on bovine chromosome (BTA) 3 (Ashton et al 1968).…”

mentioning

confidence: 99%

“…Genetic variants associated with tick burdens have been previously identified in cattle. The first association was to the serum amylase locus on bovine chromosome (BTA) 3 (Ashton et al 1968). Other studies showed that class I antigens of the bovine major histocompatibility complex (MHC), typed with a microlymphocytotoxicity test, were associated with tick load in cattle (Stear et al 1989(Stear et al , 1990.…”

mentioning

confidence: 99%

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DNA variation in the gene ELTD1 is associated with tick burden in cattle

et al. 2010

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Ticks and tick-born diseases are major constraints on cattle production in tropical and subtropical regions in the world. Previously, we identified single nucleotide polymorphisms (SNPs) associated with tick resistance on bovine chromosome 3 at approximately 70 Mb. In this study, we genotyped a dairy (n = 1133) and a beef (n = 774) sample to confirm the association of the intronic SNP rs29019303 and its gene (ELTD1) with tick burden. We genotyped 18 additional SNPs in a region of 181 kb and found that rs29019303 was significantly (P < 0.05) associated with tick burden in both samples with the same favourable allele. A second SNP in this same genomic region was also significantly associated with tick burden in each sample. The associations using haplotypes were stronger than for single markers, including a haplotype of nine tag SNPs that was highly significantly (P = 0.0008) associated with tick counts in the dairy animals. This haplotype and two others were significant after Bonferroni correction for multiple testing. The estimated size of the effects was close to 0.9% of the residual variance in both samples tested.

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An Association Between Serum Amylase Phenotype and Tick Infestation in Cattle

Cited by 12 publications

References 5 publications

Cattle Tick Rhipicephalus microplus-Host Interface: A Review of Resistant and Susceptible Host Responses

Cattle Tick Rhipicephalus microplus-Host Interface: A Review of Resistant and Susceptible Host Responses

Mapping of quantitative trait loci controlling tick [Riphicephalus (Boophilus) microplus] resistance on bovine chromosomes 5, 7 and 14

DNA variation in the gene ELTD1 is associated with tick burden in cattle

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