An association between primary biliary cirrhosis and jejunal villous atrophy resembling celiac disease

Iliffe, Gerald D.; Owen, David A.

doi:10.1007/bf01317215

Cited by 32 publications

(12 citation statements)

References 13 publications

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“…Mitochondrial antibodies, markers of PBC, did not change their titer after gluten withdrawal. Numerous case reports dealing with the association between CD and PBC have shown that gluten withdrawal produces a stable clinical and biochemical improvement thanks to the normalization of intestinal absorption, but it does not seem to modify the course of the liver disorder [56][57][58][59][60][61][62][63][64][65]. A threefold or greater increase in risk of PBC in people with CD compared with the general population has been recently demonstrated [66,67].…”

Section: Primary Biliary Cirrhosismentioning

confidence: 99%

Pathogenesis and Clinical Significance of Liver Injury in Celiac Disease

Volta

2008

Clinic Rev Allerg Immunol

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Abnormalities of liver function are one of the manifold extraintestinal manifestations of celiac disease. Although the spectrum of liver manifestations associated with celiac disease is particularly wide, two main forms of liver damage namely, cryptogenic and autoimmune, appear to be strictly related to gluten-sensitive enteropathy. The most frequent finding is represented by a cryptogenic hypertransaminasemia, observed in about a half of untreated celiac patients, as an expression of a mild liver dysfunction with a histological picture of nonspecific reactive hepatitis (celiac hepatitis) reverting to normal after 6-12 months of a strict gluten-free diet. In a few cases, when celiac disease is diagnosed, a more severe liver injury, characterized by a cryptogenic chronic hepatitis or liver cirrhosis, is present. In these patients, liver damage can still improve after a gluten-free diet institution. Moreover, a close association between celiac disease and autoimmune liver disorders has been widely demonstrated. Indeed, celiac disease has been found in 3-7% of patients with primary biliary cirrhosis, in 3-6% with autoimmune hepatitis, and in 2-3% with primary sclerosing cholangitis. Differently from cryptogenic liver injury, autoimmune liver dysfunction, found in celiac disease, does not usually improve after a gluten-free diet. Presently, it is difficult to establish if the two main kinds of liver injury found in celiac disease (cryptogenic and autoimmune) are discrete entities with a different pathogenesis or if they are an expression of the same disorder where genetic factors and the duration of gluten exposure may determine the severity and the pattern of liver injury.

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Section: Primary Biliary Cirrhosismentioning

confidence: 99%

Pathogenesis and Clinical Significance of Liver Injury in Celiac Disease

Volta

2008

Clinic Rev Allerg Immunol

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“…Since the initial description of four patients with coeliac disease (CD) and primary biliary cirrhosis (PBC) [1], there have been several subsequent reports demonstrating an association of these two diseases [2-7]. Recently, a number of epidemiological studies reported an increased, up to 7%, prevalence of CD in patients with PBC and an increased prevalence, up to 3%, of PBC in patients with CD [8,9].…”

Section: Introductionmentioning

confidence: 99%

Primary biliary cirrhosis and autoimmune cholangitis are not associated with coeliac disease in Crete

et al. 2002

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“…Later, additional cases were described 23–25. For both primary biliary cirrhosis and celiac disease, other concomitant immune-mediated conditions were noted, including diabetes and thyroiditis 25–28.…”

Section: Primary Biliary Cirrhosismentioning

confidence: 99%

Hepatic manifestations of celiac disease

Freeman¹

2010

CEG

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Different hepatic and biliary tract disorders may occur with celiac disease. Some have been hypothesized to share genetic or immunopathogenetic factors, such as primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis. Other hepatic changes in celiac disease may occur with malnutrition resulting from impaired nutrient absorption, including hepatic steatosis. In addition, celiac disease may be associated with rare hepatic complications, such as hepatic T-cell lymphoma.

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An association between primary biliary cirrhosis and jejunal villous atrophy resembling celiac disease

Cited by 32 publications

References 13 publications

Pathogenesis and Clinical Significance of Liver Injury in Celiac Disease

Pathogenesis and Clinical Significance of Liver Injury in Celiac Disease

Primary biliary cirrhosis and autoimmune cholangitis are not associated with coeliac disease in Crete

Hepatic manifestations of celiac disease

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