An Association Between Helicobacter pylori Infection and Serum Vitamin B12 Levels in Healthy Adults

Shuval-Sudai, Ora; Granot, Esther

doi:10.1097/00004836-200302000-00008

Cited by 35 publications

(49 citation statements)

References 15 publications

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“…Food-bound cobalamin malabsorption results from conditions that impair the secretion of gastric acid and pepsin required for the release of cobalamin from proteins in food [25,26]. Adult studies performed in H. pylori-infected patients revealed a high rate of vitamin B 12 deficiency [16][17][18][19][20]. The mechanism of vitamin B 12 malabsorption caused by H. pylori infection is unclear, but it may be due to the effect of H. pylori on gastric acid secretion.…”

Section: H Pylori Infection and Vitamin B 12mentioning

confidence: 99%

“…Additionally, Kurekci et al [15] showed that the eradication of H. pylori infection without iron treatment led to the resolution of iron deficiency in children. Fewer studies, performed in adults, also revealed positive relations between H. pylori and vitamin B 12 deficiency [16][17][18][19][20], whereas no obvious relation was detected between H. pylori and serum vitamin B 12 levels in a study performed without endoscopy and biopsy in children [21]. A positive relation was also reported between H. pylori and folate deficiency in adults [1].…”

Section: Introductionmentioning

confidence: 99%

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Serum Ferritin, Vitamin B12, Folate, and Zinc Levels in Children Infected with Helicobacter pylori

et al. 2007

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We sought to explore the relationship between Helicobacter pylori infection and serum ferritin, vitamin B(12), folate, and zinc status among children. Fifty patients aged 5-18 years who underwent upper gastrointestinal endoscopy because of dyspeptic symptoms, were studied, prospectively. Patients were grouped as H. pylori positive (group 1, n=32) or H. pylori negative (group 2, n=18) by histopathologic examination and rapid urease test. Fasting serum ferritin, vitamin B(12), folate, and zinc levels of patients were measured. Both groups were indifferent according to age, gender, height standard deviation score (H(SDS)), and weight standard deviation score (W(SDS)). Serum ferritin levels were 33+/-26 and 50+/-46 ng/mL (P=.098), vitamin B(12) levels were 303+/-135 and 393+/-166 pg/mL (P=.042), folate levels were 9.64+/-3.2 and 9.61+/-2.8 ng/mL (P=.979), and zinc levels were 95+/-48 and 87+/-31 mug/dL (P=.538), in groups 1 and 2, respectively. Ferritin levels of 14 (43.8%) patients in group 1 and 6 (33.3%) patients in group 2 were below the normal range (P=.470). Serum vitamin B(12) levels of 9 children (28%) in group 1 and 2 children (11%) in group 2 were below the normal range (P=.287). The findings of the present study suggest that H. pylori infection has a negative effect on serum ferritin and vitamin B(12) levels in children. This negative effect on vitamin B(12) levels is rather marked in contrast to that on ferritin levels. H. pylori infection has no significant effect on serum folate or zinc levels among children.

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Section: H Pylori Infection and Vitamin B 12mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum Ferritin, Vitamin B12, Folate, and Zinc Levels in Children Infected with Helicobacter pylori

et al. 2007

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“…pylori not only causes a local gastric response but also produces systemic effects: defects particularly in vitamin B12 absorption [15][16][17], alterations in growth hormone (GH) levels [18][19][20], increments in serum and mucosal levels of cytokines [21,22], and changes in estrogen levels [23] have all been reported in H. pylori-positive (+) individuals. Although it is well known that all these changes have the potential to influence bone remodeling, there are limited data on the alterations in biochemical markers of bone metabolism in patients with H. pylori infection.…”

Section: Introductionmentioning

confidence: 99%

Biochemical Markers of Bone Metabolism in Children with Helicobacter pylori Infection

et al. 2007

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We investigated the biochemical markers of bone metabolism in children with Helicobacter pylori infection. Biochemical markers of bone metabolism and serum levels of vitamin B12, ferritin and estradiol were measured in 41 H. pylori-positive (+) children (23 girls, 18 boys; aged 11.8+/-3 years). Serum levels of intact parathyroid hormone, ss-collagen I carboxy terminal telopeptide, total alkaline phosphatase (ALP), bone-specific ALP, N-terminal cross-links of human procollagen type I, N-mid-osteocalcin, calcium, phosphate, ferritin, and estradiol did not differ significantly between H. pylori(+) and H. pylori negative (-) children. Vitamin B12 levels were significantly decreased in H. pylori(+) compared to H. pylori(-) children. H. pylori infection was not accompanied by significant changes in markers of bone metabolism in children, although vitamin B12 levels were decreased. Further studies are required to clarify whether H. pylori infection causes time-dependent changes in bone turnover markers during the long course of this inflammatory disease.

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“…This condition impairs the absorption of vitamin B 12 -with consequent hyper-homocysteinemia [50] and a correlation between augmented systemic levels of homocysteine and SSHL development is known.…”

Section: Discussionmentioning

confidence: 99%

Is Sudden Sensori-neural Hearing Loss an Additional Extra Digestive Disease Associated with HP Infection?

Ponzetto¹,

Cavallo²,

Alushi³

et al. 2017

J Clin Gastroenterol Hepatol

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Background: Sudden Sensori-neural Hearing Loss (SSHL) is an abrupt failure of the cochlear function of unknown etiology. Possible causes include chronic infections leading to increased systemic levels of cytokines, which could damage the cochlear pumps H + , K + -and Na + , K + -ATPases. Helicobacter pylori infection stimulates systemic cytokine production. Proton pumps in cochlea and stomach are almost identical.

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An Association Between Helicobacter pylori Infection and Serum Vitamin B12 Levels in Healthy Adults

Abstract: The higher prevalence of H. pylori infection among subjects with serum vitamin B12 levels that are within the lower end of the normal range suggests a causal relationship between H pylori infection and vitamin B12 levels in healthy adults.

Cited by 35 publications

References 15 publications

Serum Ferritin, Vitamin B12, Folate, and Zinc Levels in Children Infected with Helicobacter pylori

Serum Ferritin, Vitamin B12, Folate, and Zinc Levels in Children Infected with Helicobacter pylori

Biochemical Markers of Bone Metabolism in Children with Helicobacter pylori Infection

Is Sudden Sensori-neural Hearing Loss an Additional Extra Digestive Disease Associated with HP Infection?

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