Biochemical Markers of Bone Metabolism in Children with Helicobacter pylori Infection

Abstract

We investigated the biochemical markers of bone metabolism in children with Helicobacter pylori infection. Biochemical markers of bone metabolism and serum levels of vitamin B12, ferritin and estradiol were measured in 41 H. pylori-positive (+) children (23 girls, 18 boys; aged 11.8+/-3 years). Serum levels of intact parathyroid hormone, ss-collagen I carboxy terminal telopeptide, total alkaline phosphatase (ALP), bone-specific ALP, N-terminal cross-links of human procollagen type I, N-mid-osteocalcin, calcium, phosphate, ferritin, and estradiol did not differ significantly between H. pylori(+) and H. pylori negative (-) children. Vitamin B12 levels were significantly decreased in H. pylori(+) compared to H. pylori(-) children. H. pylori infection was not accompanied by significant changes in markers of bone metabolism in children, although vitamin B12 levels were decreased. Further studies are required to clarify whether H. pylori infection causes time-dependent changes in bone turnover markers during the long course of this inflammatory disease.

Chlamydia pneumoniae and Helicobacter pylori IgG seropositivities are not predictors of osteoporosis-associated bone loss: a prospective cohort study

“…Similar to the findings of a study in children that found that H. pylori infection was not accompanied by significant changes in circulating estradiol, parathyroid hormone, cross-linked collagen I carboxy terminal telopeptide, bonespecific alkaline phosphatase, N-terminal cross-links of human pro-collagen type I, N-mid-osteocalcin, calcium, and phosphate [8], we did not find significant differences in bone turnover markers between IgG H. pylori positive and IgG H. pylori negative postmenopausal women.…”

“…This proinflammatory response and the release of inflammatory cytokines in H. pylori infection may indicate a plausible role for this organism in bone resorption. However, only 4 studies in the medical literature investigated H. pylori infection in relation to bone health, all of which reported contradictory findings [8][9][10][11]. In contrast to a case-control study that reported a higher prevalence of CagA-positive strains in osteoporotic men, two studies with small samples of women showed that H. pylori infection with or without chronic atrophic gastritis in postmenopausal women [11] and H. pylori associated gastritis in women [10] were not associated with decreased BMD.…”

“…Neither C. pneumoniae nor H. pylori IgG seropositivity was associated with age-and body mass controversial [7]. There are also limited contradictory studies regarding the relationship between osteoporosis and infection with H. pylori [8][9][10][11]. Infection with H. pylori in children was not associated with significant changes in bone metabolism [8].…”

“…There are also limited contradictory studies regarding the relationship between osteoporosis and infection with H. pylori [8][9][10][11]. Infection with H. pylori in children was not associated with significant changes in bone metabolism [8]. However, infection by CagA-positive H. pylori strains was more prevalent in osteoporotic men [9].…”

“…Given the contradictory data on the association between H. pylori infection and bone metabolism [8][9][10][11] and the very limited studies on C. pneumoniae infection and osteoporosis in humans [10], more studies are required to clarify the involvement of chronic infection with these organisms in bone health. The aim of this prospective, populationbased study was to evaluate the potential link between infections with H. pylori and C. pneumoniae and bone mineral density (BMD) in a sample of postmenopausal women.…”