An association between a lymphocyte antigen in sheep and the response to vaccination against the parasite Trichostrongylus colubriformis

Outteridge, P.M.; Windon, R.G.; Dineen, J.K.

doi:10.1016/0020-7519(85)90076-1

Cited by 48 publications

(11 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The MHC chromosomal area has also been a common candidate in the search for markers of resistance useful in ruminant selection programs. In this regard, several studies have found an association between parasite resistance and MHC markers (30,33,44,45,46,52,58), although lack of association (13,18,57) or genetic linkage (19) has also been reported. Taking into account the contradictory results found in the literature, we suspect that the increased expression of MHC class II in the resistant lambs may only be effective in reducing parasite infection if combined with a set of MHC alleles that are efficient at presenting parasite antigens.…”

Section: Discussionmentioning

confidence: 99%

Microarray analysis of selection lines from outbred populations to identify genes involved with nematode parasite resistance in sheep

Diez-Tascón

Keane

Wilson

et al. 2005

Physiological Genomics

107

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Microarray analysis of selection lines from outbred populations to identify genes involved with nematode parasite resistance in sheep

Diez-Tascón

Keane

Wilson

et al. 2005

Physiological Genomics

107

View full text Add to dashboard Cite

show abstract

“…They were followed by studies demonstrating that MHC genes also play a role in regulating GI nematode infections in sheep (Outteridge et al, 1985(Outteridge et al, , 1988Schwaiger et al, 1995;Stear et al, 1996;Paterson et al, 1998) and other domestic animals (Stear et al, 1988;Stear & Wakelin, 1998). The MHC locus encodes primarily genes that are involved in recognition of foreignness (non-self), including the class 1 and class 2 antigen presenting molecules on cells such as macrophages and dendritic cells.…”

Section: Mhc Based Genesmentioning

confidence: 99%

Chasing the genes that control resistance to gastrointestinal nematodes

et al. 2003

View full text Add to dashboard Cite

The host-protective immune response to infection with gastrointestinal (GI) nematodes involves a range of interacting processes that begin with recognition of the parasite's antigens and culminate in an inflammatory reaction in the intestinal mucosa. Precisely which immune effectors are responsible for the loss of specific worms is still not known although many candidate effectors have been proposed. However, it is now clear that many different genes regulate the response and that differences between hosts (fast or strong versus slow or weak responses) can be explained by allelic variation in crucial genes associated with the gene cascade that accompanies the immune response and/or genes encoding constitutively expressed receptor/signalling molecules. Major histocompatibility complex (MHC) genes have been recognized for some time as decisive in controlling immunity, and evidence that non-MHC genes are equally, if not more important in this respect has also been available for two decades. Nevertheless, whilst the former have been mapped in mice, only two candidate loci have been proposed for non-MHC genes and relatively little is known about their roles. Now, with the availability of microsatellite markers, it is possible to exploit linkage mapping techniques to identify quantitative trait loci (QTL) responsible for resistance to GI nematodes. Four QTL for resistance to Heligmosomoides polygyrus, and additional QTL affecting faecal egg production by the worms and the accompanying immune responses, have been identified. Fine mapping and eventually the identification of the genes (and their alleles) underlying QTL for resistance/susceptibility will permit informed searches for homologues in domestic animals, and human beings, through comparative genomic maps. This information in turn will facilitate targeted breeding to improve resistance in domestic animals and, in human beings, focused application of treatment and control strategies for GI nematodes.

show abstract

“…The majority of the associations between MHC-DQA2 and various parameters of parasite resistance were age and parasite-count specific, s uggesting that immune response is both age and challenge (combination of parasites) dependent (Hickford et al, 2011). Outteridge et al (1985) found associations between resistance to T. colubriformis and MHC Class I in different lines of sheep. However, the relationship between MHC Class I and sheep selected for low FEC was not observed in a later study (Outteridge et al, 1986).…”

Section: Major Histocompatibility Complex (Mhc I and Ii)mentioning

confidence: 92%

Immune and other factors modulating host resistance against gastrointestinal nematode parasites in sheep

Arsenopoulos

Symeonidou

Papadopoulos

2018

J Hellenic Vet Med Soc

View full text Add to dashboard Cite

Infection of small ruminants with gastrointestinal nematode (GIN) parasites is a significant problem with crucial impact on meat and milk production. The strategy of administrating anthelminthic drugs has been implemented for many years and has resulted in the development of resistant strains of parasites. Meanwhile, consumers demand for free of drugs products have led to the adoption of alternative control methods, which involve the selective breeding of animals, which are resistant to parasitism. The development of immunity and therefore, resistance against gastrointestinal parasites is based on the activation of specific host genes. Gene analysis has revealed areas (QTLs), which affect resistance or susceptibility of sheep to gastrointestinal infestations between animals of different breeds and between individuals of the same breed. The role of cytokines and T helper cells has been enhanced as research, strongly, supports the connection of Th2 cells with resistance and Th1 cells with susceptibility against GIN. Latest data implicates T regulatory cells and a specific cell type, Th17, in immune response mechanisms. Specific adhesion molecules (integrins, lectins, cadherins) are produced in the gut lumen in sufficient amounts and appear to boost immunity and reduce clinical signs in sheep. Additionally, the immunoglobulins IgA and IgE have been positively correlated with increased resistance against GIN. In several cases of GIN, where an increased number of eosinophils and mast cells in the intestinal epithelium have been recorded, the animals had a reduced number of parasite eggs in their feces. The genes of the Major Histocompatibility Complex have been referred to as potential resistance or susceptibility markers. Other enzymes, like chitinases, enhance the resilience of animals and protect them effectively. Animal’s nutritional status is another determinant factor of immune capability against GIN in sheep, both systemic, as well as locally. Regarding the effect of reactive oxygen and nitrogen species, some researchers support their direct effect against GIN, resulting in a natural reduction of their number, while others claim the indirect action in the intestinal epithelium by reducing local immunity. Consequently, the detection of genes associated with resistance or susceptibility to gastrointestinal infestations is promising and in line with modern requirements.

show abstract

An association between a lymphocyte antigen in sheep and the response to vaccination against the parasite Trichostrongylus colubriformis

Cited by 48 publications

References 16 publications

Microarray analysis of selection lines from outbred populations to identify genes involved with nematode parasite resistance in sheep

Microarray analysis of selection lines from outbred populations to identify genes involved with nematode parasite resistance in sheep

Chasing the genes that control resistance to gastrointestinal nematodes

Immune and other factors modulating host resistance against gastrointestinal nematode parasites in sheep

Contact Info

Product

Resources

About