An Assessment of Gastric Emptying by Breathalyser

Finch, Joanne; Kendall, M. J.; Mitchard, M.

doi:10.1111/j.1365-2125.1974.tb00242.x

Cited by 30 publications

(22 citation statements)

References 11 publications

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“…This appears to be reproducible, mean time to peak being 20.71 min in both placebo studies (Table 1). This is more rapid than in other reported studies (Finch et al, 1974). It may reflect the effect of a warm fluid (Bateman et al, 1977) or the low dose of ethanol used.…”

Section: Lcebo Prolactincontrasting

confidence: 46%

“…In addition, the effect of the drug on gastric emptying is not apparent under some test conditions in normals (Ramsbottom & Hunt, 1970) but clear in others (Kreel et al, 1972). The measurement of drug (Heading, Nimmo, Prescott & Tothill, 1973) or ethanol (Finch, Kendall & Mitchard, 1974;Gibbons & Lant, 1975) absorption is an index of gastric emptying rate. We have used ethanol absorption as a method of measuring gastric emptying.…”

Section: Lcebo Prolactinmentioning

confidence: 99%

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Pharmacokinetic and concentration‐effect studies with intravenous metoclopramide.

Bateman¹,

Kahn²,

Mashiter³

et al. 1978

Brit J Clinical Pharma

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1 Pharmacokinetic and concentration‐effect studies have been carried out following intravenous injection of 10 mg metoclopramide hydrochloride to seven normal male volunteers. 2 It is proposed that a two‐compartment model adequately describes the disposition of the drug which is rapidly distributed (T1/2alpha = 4.9 +/‐ 1.1 min) and eliminated (T1/2beta = 165.7 +/‐ 20.2 min). Total body plasma clearance of the drug is high (10.9 +/‐ 1.5 ml min‐1 kg‐1) and approximates to liver plasma flow. 3 Metoclopramide i.v. increases gastric emptying as measured by an ethanol absorption test (P less than 0.005). The duration of this effect is at least 3 h. 4 Ethanol given after i.v. metoclopramide administration produces significant sedation during the first hour and at 3 h (P less than 0.001). 5 The effect of metoclopramide on gastric emptying, and the degree of sedation induced by ethanol would appear to be related to plasma metoclopramide concentration. 6 Metoclopramide increases serum prolactin to 59 +/‐ 5.8 microgram/1 at 30 min after injection. There is a linear relationship (r = 0.809) between serum prolactin increase and plasma metoclopramide concentration.

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Section: Lcebo Prolactincontrasting

confidence: 46%

Section: Lcebo Prolactinmentioning

confidence: 99%

Pharmacokinetic and concentration‐effect studies with intravenous metoclopramide.

Bateman¹,

Kahn²,

Mashiter³

et al. 1978

Brit J Clinical Pharma

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show abstract

“…This is a convincing demonstration of the dependence of drug absorption on stomach emptying. In none of the previous studies relating drug absorption and gastric emptying (Heading et al, 1973;Nimmo et al, 1973;Finch et al, 1974) has such a relationship been established on the basis of simultaneous measurements.…”

Section: Discussionmentioning

confidence: 99%

“…The present findings have wide therapeutic implications. There is an increasing awareness of the role of gastric emptying rate in influencing the absorption of orally administered drugs (Heading et al, 1973;Nimmo et al, 1973;Finch, Kendall & Mitchard, 1974;Volans, 1974;Ahmad, 1974).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of gastric emptying and drug absorption by narcotic analgesics.

Nimmo¹,

Heading²,

Wilson³

et al. 1975

Brit J Clinical Pharma

255

115

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“…The influence of gastric retention and intestinal motility on drug absorption has been investigated by Nimmo (6) and others (7,8). Metoclopramide (Maxolon®, Beecham) has been shown to decrease gastric retention and increase intestinal motility (9), and this results in an increased rate of absorption of a number of drugs.…”

Section: Introductionmentioning

confidence: 99%

Factors influencing the absorption of oxprenolol A pharmacokinetic study

Kendall

Mitchard

West

et al. 1976

European Journal of Drug Metabolism and Pharmacokinetics

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The absorption and elimination of oxprenolol after intravenous and oral administration has been studied in six healthy male volunteers.The plasma concentration/time curve after intravenous administration is described by an equation consisting of three exponential terms. The terminal half-life of 4.5 hours is longer than previously reported and is consistent with the observed effect on heart rate after a single dose.The bioavailability of oxprenolol has been estimated from a comparison of the area under the curve values after oral and intravenous administration, and shown to be 25 % and 30 % for 80 mg oxprenolol in tablet and solution form respectively. Treatment of the volunteers with either metoclopramide which decreases gastric retention and increases intestinal motility, or neomycin which produces a deterioration in the integrity of the intestinal mucosa, did not appear to alter the absorption of oxprenolol.

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An Assessment of Gastric Emptying by Breathalyser

Cited by 30 publications

References 11 publications

Pharmacokinetic and concentration‐effect studies with intravenous metoclopramide.

Pharmacokinetic and concentration‐effect studies with intravenous metoclopramide.

Inhibition of gastric emptying and drug absorption by narcotic analgesics.

Factors influencing the absorption of oxprenolol A pharmacokinetic study

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