An assessment of cerebrolysin effect on BDNF level in patients with post stroke aphasia depending on carbohydrate metabolism disorders

Шишкова, В Н; Zotova, L.; Maljukova, N G; Sutjusheva, I R; Kan, Nean-Been; Gasanova, E M; Kerimova, E I

doi:10.17116/jnevro20151155157-63

Cited by 5 publications

(5 citation statements)

References 12 publications

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“…In another study, cerebrolysin was confirmed to reduce neuronal cell death and increase neurogenesis and brain functions in diverse brain diseases, such as mouse closed head injury (mCHI) and stroke (Zhang L. et al, 2013;Zhang Y. et al, 2013). In addition, it has been shown in many previous studies that cerebrolysin promotes neuroprotection and neurogenesis by increasing the expression of factors such as NGF and brain-derived neurotrophic factor (BDNF) (Rockenstein et al, 2015;Shishkova et al, 2015;Alvarez et al, 2016). In this way, cerebrolysin has shown positive effects in several brain diseases.…”

Section: Introductionmentioning

confidence: 93%

Effects of Cerebrolysin on Hippocampal Neuronal Death After Pilocarpine-Induced Seizure

et al. 2020

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Epilepsy is one of the most common and severe brain diseases. The exact cause of epilepsy is unclear. Epilepsy often occurs following brain damage, such as traumatic brain injury (TBI) and ischemia. Cerebrolysin is a porcine brain peptide that is a unique neurotropic and neuroprotective agent. Cerebrolysin has been reported to increase neuroprotective effects after TBI, ischemia, and other CNS diseases. However, the effects of cerebrolysin on seizures are not known. Therefore, this study aimed to investigate the effects of neuropeptide cerebrolysin on neuronal death in the hippocampus after a seizure. To confirm the effects of cerebrolysin, we used a pilocarpine-induced seizure animal model. Cerebrolysin (2.5 ml/kg, i.p., once per day for 7 days) was immediately injected after a seizure induction. After 1 week, we obtained brain tissues and performed staining to histologically evaluate the potentially protective effects of cerebrolysin on seizure-induced neuronal death in the hippocampus. We found that cerebrolysin decreased hippocampal neuronal death after a seizure. In addition, an increase in brain-derived neurotrophic factor (BDNF) was confirmed through Western blot analysis to further support our hypothesis. Therefore, the present study suggests that the administration of cerebrolysin can be a useful therapeutic tool for preventing neuronal death after a seizure.

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Section: Introductionmentioning

confidence: 93%

Effects of Cerebrolysin on Hippocampal Neuronal Death After Pilocarpine-Induced Seizure

et al. 2020

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“…In previous studies using rat ischemia models, it was found that when BDNF synthesis was blocked, the beneficial effects on the recovery of skilled reaching were mostly negated [79], while intravenous administration of BDNF significantly enhanced the functional motor recovery of the treated rats, compared to the untreated controls [80,81]. Behavioral and physical therapies, such as aerobic/physical exercise, transcranial direct current stimulation (tDCS), and extremely lowfrequency electromagnetic field therapy (ELF-EMF), were all found to increase the blood and/or brain levels of BDNF [72,77,[82][83][84][85]. In addition, BDNF-mediated learning memory may also be partially involved in the poststroke rehabilitation of motor function and language relearning [86-88].…”

Section: Bdnf Induces Neuroplasticity In Poststroke Rehabilitationmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities

et al. 2020

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With the rise in the aging global population, stroke comorbidities have become a serious health threat and a tremendous economic burden on human society. Current therapeutic strategies mainly focus on protecting neurons from cytotoxic damage at the acute phase upon stroke onset, which not only is a difficult way to ameliorate stroke symptoms but also presents a challenge for the patients to receive effective treatment in time. The brain-derived neurotrophic factor (BDNF) is the most abundant neurotrophin in the adult brain, which possesses a remarkable capability to repair brain damage. Recent promising preclinical outcomes have made BDNF a popular late-stage target in the development of novel stroke treatments. In this review, we aim to summarize the latest progress in the understanding of the cellular/molecular mechanisms underlying stroke pathogenesis, current strategies and difficulties in drug development, the mechanism of BDNF action in poststroke neurorehabilitation and neuroplasticity, and recent updates in novel therapeutic methods.

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“…a.u., arbitrary units. References: TNF-α 134 ; NGF 135,136 ; VEGF 137,138 ; BDNF 139 ; IGF-1 76,[131][132][133] ; Neuroreaction (Neurogenesis, Neuroplasticity, Neuroinflammation) 138,140,141 ; Cerebrolysin effects on TNF-α, 61,142 NGF, 63 VEGF, 66 BDNF, 64,65 and IGF-1. 61 [Color figure can be viewed at wileyonlinelibrary.com] neurons.…”

Section: Neurogenesis In Tbimentioning

confidence: 99%

“…1.4 | NTFs in dementia, stroke, and TBI pathologies NTF profiles are imbalanced across various CNS pathologies, which is why pharmacological interventions with the ability to modulate NTF expression are of particular interest. One such drug is Cerebrolysin, which has been reported to influence the expression of TNF-α, 61,62 NGF, 63 IGF-1, 61 BDNF, 64,65 and VEGF. 66 Intriguingly, these five NTFs are also demonstrably imbalanced in brain pathologies such as dementia, 67-71 stroke [72][73][74][75][76] and traumatic brain injury (TBI) [77][78][79][80][81] (Supporting Information: Figure S1).…”

Section: Ntfs: Neuroinflammationmentioning

confidence: 99%

“…288 Cerebrolysin is registered for the treatment of stroke, TBI and dementia and shows an excellent clinical safety profile. 287,289 Cerebrolysin has been shown to upregulate VEGF, 66 BDNF, 64,65 IGF-1, 61 and NGF, 63 to downregulate TNF-α, and to induce pro-NGF/NGF conversion (Figure 3, 4, and 5).…”

Section: Modulation Of Ntfs To Treat Dementia Stroke and Tbi Pathologiesmentioning

confidence: 99%

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Modulation of neurotrophic factors in the treatment of dementia, stroke and TBI: Effects of Cerebrolysin

Rejdak

Sienkiewicz-Jarosz

Bieńkowski

et al. 2023

Medicinal Research Reviews

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Neurotrophic factors (NTFs) are involved in the pathophysiology of neurological disorders such as dementia, stroke and traumatic brain injury (TBI), and constitute molecular targets of high interest for the therapy of these pathologies. In this review we provide an overview of current knowledge of the definition, discovery and mode of action of five NTFs, nerve growth factor, insulin‐like growth factor 1, brain derived NTF, vascular endothelial growth factor and tumor necrosis factor alpha; as well as on their contribution to brain pathology and potential therapeutic use in dementia, stroke and TBI. Within the concept of NTFs in the treatment of these pathologies, we also review the neuropeptide preparation Cerebrolysin, which has been shown to resemble the activities of NTFs and to modulate the expression level of endogenous NTFs. Cerebrolysin has demonstrated beneficial treatment capabilities in vitro and in clinical studies, which are discussed within the context of the biochemistry of NTFs. The review focuses on the interactions of different NTFs, rather than addressing a single NTF, by outlining their signaling network and by reviewing their effect on clinical outcome in prevalent brain pathologies. The effects of the interactions of these NTFs and Cerebrolysin on neuroplasticity, neurogenesis, angiogenesis and inflammation, and their relevance for the treatment of dementia, stroke and TBI are summarized.

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An assessment of cerebrolysin effect on BDNF level in patients with post stroke aphasia depending on carbohydrate metabolism disorders

Abstract: The use of cerebrolysin in the complex treatment of patients with post stroke aphasia of different severity improves the prognosis of their rehabilitation.

Cited by 5 publications

References 12 publications

Effects of Cerebrolysin on Hippocampal Neuronal Death After Pilocarpine-Induced Seizure

Effects of Cerebrolysin on Hippocampal Neuronal Death After Pilocarpine-Induced Seizure

Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities

Modulation of neurotrophic factors in the treatment of dementia, stroke and TBI: Effects of Cerebrolysin

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