An assembly disposable degassing microfluidic device using a gas-permeable hydrophobic membrane and a reusable microsupport array

Cho, Hyungseok; Kim, Jin-Ho; Han, Ki-Ho

doi:10.1016/j.snb.2019.01.118

Cited by 11 publications

(6 citation statements)

References 37 publications

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“…The data also imply that the degassing rate obtained using the substrate with the micropillar array increased slightly compared to that obtained using the bare glass substrate, because the gas can be easily evacuated through the micropillar array. In particular, when the height of the micropillar array exceeds 4.2 μm, it no longer acts as a gas flow resistance [ 47 ]. As the vacuum pressure increases and the thickness of the degassing wall becomes thinner, the difference in degassing rates between the two experiments gradually increases.…”

Section: Resultsmentioning

confidence: 99%

“…This degassing rate is similar to the previously reported in-plane degassing methods [ 9 , 39 ] where a vacuum tube was directly connected to the degassing line. Previously developed degassing method that used the PDMS membrane [ 47 ] was difficult to handle due to the high flexibility of the PDMS membrane. A substrate with a micropillar array was required to support the PDMS membrane for gas emission and to prevent it from sticking to the substrate.…”

Section: Discussionmentioning

confidence: 99%

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Lateral Degassing Method for Disposable Film-Chip Microfluidic Devices

et al. 2021

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It is critical to develop a fast and simple method to remove air bubbles inside microchannels for automated, reliable, and reproducible microfluidic devices. As an active degassing method, this study introduces a lateral degassing method that can be easily implemented in disposable film-chip microfluidic devices. This method uses a disposable film-chip microchannel superstrate and a reusable substrate, which can be assembled and disassembled simply by vacuum pressure. The disposable microchannel superstrate is readily fabricated by bonding a microstructured polydimethylsiloxane replica and a silicone-coated release polymeric thin film. The reusable substrate can be a plate that has no function or is equipped with the ability to actively manipulate and sense substances in the microchannel by an elaborately patterned energy field. The degassing rate of the lateral degassing method and the maximum available pressure in the microchannel equipped with lateral degassing were evaluated. The usefulness of this method was demonstrated using complex structured microfluidic devices, such as a meandering microchannel, a microvortex, a gradient micromixer, and a herringbone micromixer, which often suffer from bubble formation. In conclusion, as an easy-to-implement and easy-to-use technique, the lateral degassing method will be a key technique to address the bubble formation problem of microfluidic devices.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lateral Degassing Method for Disposable Film-Chip Microfluidic Devices

et al. 2021

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“…Liu et al 9 reported an upstream liquid-directed nozzle-type channel with a poly(tetrafluoroethylene) (PTFE) venting membrane placed on top for rapid bubble removal. Moreover, Cho et al 10 reported an assembly disposable degassing method based on a microchannel network with an integrated poly(dimethylsiloxane) (PDMS) membrane. The reusable membrane, containing micro-support arrays, can be assembled and disassembled by vacuum pressure.…”

Section: Introductionmentioning

confidence: 99%

Underwater magneto-driven air de-bubbler

et al. 2022

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“…To remove these unexpected air bubbles in microdevices, many efforts have been attempted such as bubble traps, , separation chambers, hydrophobic membranes, and low-polarity liquid (e.g., ethanol and PBS). Recently, the involvement of numerical simulation has been regarded as an effective approach to investigate fluid behavior in microfluidics.…”

Section: Introductionmentioning

confidence: 99%

“…However, unwanted bubbles can also lead to severe cell damage by rupturing the cell membrane 10,11 and device malfunction by disrupting the local electric field. 12 To remove these unexpected air bubbles in microdevices, many efforts have been attempted such as bubble traps, 10,13 separation chambers, 14 hydrophobic membranes, 15 and lowpolarity liquid (e.g., ethanol 16 and PBS 17 ). Recently, the involvement of numerical simulation has been regarded as an effective approach to investigate fluid behavior in microfluidics.…”

Section: ■ Introductionmentioning

confidence: 99%

How to Prevent Bubbles in Microfluidic Channels

Wang

Meng

et al. 2021

Langmuir

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Microfluidic technology has aroused wide applications, including analytical science, diagnostic technology, and micro-/nanofabrication. However, bubbles in microfluidic channels always bring out adverse impacts such as cell damage and device malfunction. To prevent bubble formation, numerical simulation and experiments were integrated to reveal the effect of the factors including the internal structure of the channel, internal wettability, and liquid flow rate. On one hand, the simulation results reveal that bubble formation can be prevented by these mentioned factors, the weight of which can be provided by a logistic regression model. In addition, the raised equilibrium equations can efficiently explain the influence of these factors on bubble prevention. On the other hand, the validity of the simulation was further verified by the prevention of bubbles in the water-flowing microchannels. Therefore, this work provides a promising strategy to prevent bubble formation in microchannels, which has wide applications in microfluidic systems.

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An assembly disposable degassing microfluidic device using a gas-permeable hydrophobic membrane and a reusable microsupport array

Cited by 11 publications

References 37 publications

Lateral Degassing Method for Disposable Film-Chip Microfluidic Devices

Lateral Degassing Method for Disposable Film-Chip Microfluidic Devices

Underwater magneto-driven air de-bubbler

How to Prevent Bubbles in Microfluidic Channels

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