An ascorbic acid amperometric sensor using over-oxidized polypyrrole and palladium nanoparticles composites

Shi, Wentao; Liu, Chunxiu; Song, Yilin; Lin, Nianyun; Zhou, Shuai; Cai, Xinxia

doi:10.1016/j.bios.2012.05.004

Cited by 50 publications

(16 citation statements)

References 40 publications

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“…Nanostructured composites such as palladium (Pd) nanowire-modified graphene [55], multiwall CNTs dispersed in polyhistidine [56], Fe 3 O 4 @gold (Au)-loaded graphene [57] and ZnO nanowire on hierarchical graphene [58] were reported for developing the sensitivity and selectivity of AA. Moreover, other nanocomposites including graphenegrafted PANI [52], graphene-supported platinum (Pt) nanoparticles [59], over-oxidized polypyrrole, PdNPs/Au [60] and 3D graphene foam CuO nanoflowers [61] have been exploited for determining AA.…”

Section: Introductionmentioning

confidence: 99%

A highly sensitive biosensor based on methacrylated graphene oxide-grafted polyaniline for ascorbic acid determination

Naghib

Behzad

Rahmanian

et al. 2020

Nanotechnology Reviews

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Functionalized graphene-based nanocomposites have opened new windows to address some challenges for increasing the sensitivity, accuracy and functionality of biosensors. Polyaniline (PANI) is one of the most potentially promising and technologically important conducting polymers, which brings together the electrical features of metals with intriguing properties of plastics including facile processing and controllable chemical and physical properties. PANI/graphene nanocomposites have attracted intense interest in various fields due to unique physicochemical properties including high conductivity, facile preparation and intriguing redox behavior. In this article, a functionalized graphene-grafted nanostructured PANI nanocomposite was applied for determining the ascorbic acid (AA) level. A significant current response was observed after treating the electrode surface with methacrylated graphene oxide (MeGO)/PANI nanocomposite. The amperometric responses showed a robust linear range of 8–5,000 µM and detection limit of 2 µM (N = 5). Excellent sensor selectivity was demonstrated in the presence of electroactive components interfering species, commonly found in real serum samples. This sensor is a promising candidate for rapid and selective determination of AA.

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Section: Introductionmentioning

confidence: 99%

A highly sensitive biosensor based on methacrylated graphene oxide-grafted polyaniline for ascorbic acid determination

Naghib

Behzad

Rahmanian

et al. 2020

Nanotechnology Reviews

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“…2d ). The detection limit for vitamin C, calculated as the concentration corresponding to triple standard deviations of the background signal, is 9.1 nM, achieving two orders of magnitude lower than that of the electrochemical methods 23 .…”

Section: Resultsmentioning

confidence: 82%

Background-free in-vivo Imaging of Vitamin C using Time-gateable Responsive Probe

Song

Yang

et al. 2015

Sci Rep

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Sensitive optical imaging of active biomolecules in the living organism requires both a molecular probe specifically responsive to the target and a high-contrast approach to remove the background interference from autofluorescence and light scatterings. Here, a responsive probe for ascorbic acid (vitamin C) has been developed by conjugating two nitroxide radicals with a long-lived luminescent europium complex. The nitroxide radical withholds the probe on its “off” state (barely luminescent), until the presence of vitamin C will switch on the probe by forming its hydroxylamine derivative. The probe showed a linear response to vitamin C concentration with a detection limit of 9.1 nM, two orders of magnitude lower than that achieved using electrochemical methods. Time-gated luminescence microscopy (TGLM) method has further enabled real-time, specific and background-free monitoring of cellular uptake or endogenous production of vitamin C, and mapping of vitamin C in living Daphnia magna. This work suggests a rational design of lanthanide complexes for background-free small animal imaging of biologically functional molecules.

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“…Electrochemical polymerization is based on electrostatic interaction. In the process of electropolymerization, enzymes act as anions and interact with positively charged polymer skeletons, and enzyme is added to the polymer membrane and directly immobilized on the electrode surface [15].…”

Section: (5) Electrochemical Polymerizationmentioning

confidence: 99%

Enzyme Biosensors for Point-of-Care Testing

Liu¹,

Xu²,

Xue³

et al. 2018

MEMS Sensors - Design and Application

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Biosensors are devices that integrate a variety of technologies, containing biology, electronics, chemistry, physics, medicine, informatics, and correlated technology. Biosensors act as transducer with a biorecognition element and transform a biochemical reaction on the transducer surface directly into a measurable signal. The biosensors have the advantages of rapid analysis, low cost, and high precision, which are widely used in many fields, such as medical care, disease diagnosis, food detection, environmental monitoring, and fermentation industry. The enzyme biosensors show excellent application value owing to the development of fixed technology and the characteristics of specific identification, which can be combined with point-of-care testing (POCT) technology. POCT technology is attracting more and more attention as a very effective method of clinic detection. We outline the recent advances of biosensors in this chapter, focusing on the principle and classification of enzyme biosensor, immobilization method of biorecognition layers, and fabrication of amperometric biosensors, as well as the applications of POCT. A summary of glucose biosensor development and integrated setups is included. The latest applications of enzyme biosensors in diagnostic applications focusing on POCT of biomarkers in real samples were described.

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An ascorbic acid amperometric sensor using over-oxidized polypyrrole and palladium nanoparticles composites

Cited by 50 publications

References 40 publications

A highly sensitive biosensor based on methacrylated graphene oxide-grafted polyaniline for ascorbic acid determination

A highly sensitive biosensor based on methacrylated graphene oxide-grafted polyaniline for ascorbic acid determination

Background-free in-vivo Imaging of Vitamin C using Time-gateable Responsive Probe

Enzyme Biosensors for Point-of-Care Testing

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