An artificial nerve fiber for evaluation of nerve cuff electrodes

Andreasen, L.N.S.; Struijk, Johannes; Haugland, Morten Kristian

doi:10.1109/iembs.1997.758734

Cited by 17 publications

(23 citation statements)

References 6 publications

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“…In order to fill the gap between conventional validation tools (simulators and classic test benches) and the ex vivo or in vivo experiments, an interesting solution consists in artificially replicating living organs [1]. These solutions are called phantoms.…”

Section: Journal Of Sensorsmentioning

confidence: 99%

Efficient Objective Metric Tool for Medical Electrical Device Development: Eye Phantom for Glaucoma Diagnosis Device

et al. 2017

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Developing electronic medical devices is challenging. Simulations or in vivo experiments are not sufficient to obtain pertinent comparisons between potential design options. This paper presents a new artificial tool allowing objective comparisons between electronic device topologies. The main idea is to build a tool which is sensitive to targeted biological parameters only. These tools are generally called phantoms. The phantom presented in this paper is dedicated to IntraOcular Pressure (IOP) Measurement devices used in glaucoma diagnosis and treatment. It is called Biomechanical Eye Emulator (BEE). The BEE emulates the main biomechanical parameters influencing the IOP measurements. Because it is not sensitive to the living context, the BEE is the most efficient tool to investigate the best sensor design. BEE specifications are defined to be as close as possible to chosen models (humans or animals). Its efficiency is shown with a case study on rabbits. The results clearly demonstrate the BEE phantoms efficacy in providing objective assessment metrics during the sensor design process.

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Section: Journal Of Sensorsmentioning

confidence: 99%

Efficient Objective Metric Tool for Medical Electrical Device Development: Eye Phantom for Glaucoma Diagnosis Device

et al. 2017

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“…For other models, this is standard practice, as the bulk conductivity properties are similar to those of tissue with regards to electrode testing [43,56].…”

Section: Tissue Mimicmentioning

confidence: 99%

“…Previous test platforms have focused on a single electrode type, and testing for that specific design only [43,56]. A broad-based test platform that can be used for a range of electrodes is needed to allow a better understanding of how each different electrode reports the AP signal, to be able to make comparisons.…”

Section: The Need For a Common Electrode Test Platformmentioning

confidence: 99%

“…One example of this phenomena can be found with cuff electrodes. Rieger [43], Andreasson [56], and Yoshida [55] have all developed their own test platforms. Rieger et al created a test model that implemented a limited number of electrodes mimicking an axonal segment.…”

Section: The Need For a Common Electrode Test Platformmentioning

confidence: 99%

“…Electromechanical models that emulate an AP also exist. One model constructs a complex amplitude controlled signal that is applied to a small set of electrodes that in turn emulate a propagating multiaxonal AP, while the other uses a single source point that is translated by moving throughout the fixed position cuff ring [43,56]. Other sources that could be used are once again in vitro cell cultures but their limitations must be understood and culture conditions that must be maintained throughout the complete experimental investigation.…”

mentioning

confidence: 99%

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The Physical Axon : Modeling, Simulation and Electrode Evaluation

Latorre¹

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A phantom axon setup for validating models of action potential recordings

Rossel

Soulier

Bernard

et al. 2016

Med Biol Eng Comput

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Electrode designs and strategies for electroneurogram recordings are often tested first by computer simulations and then by animal models, but they are rarely implanted for long-term evaluation in humans. The models show that the amplitude of the potential at the surface of an axon is higher in front of the nodes of Ranvier than at the internodes; however, this has not been investigated through in vivo measurements. An original experimental method is presented to emulate a single fiber action potential in an infinite conductive volume, allowing the potential of an axon to be recorded at both the nodes of Ranvier and the internodes, for a wide range of electrode-to-fiber radial distances. The paper particularly investigates the differences in the action potential amplitude along the longitudinal axis of an axon. At a short radial distance, the action potential amplitude measured in front of a node of Ranvier is two times larger than in the middle of two nodes. Moreover, farther from the phantom axon, the measured action potential amplitude is almost constant along the longitudinal axis. The results of this new method confirm the computer simulations, with a correlation of 97.6 %.

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An artificial nerve fiber for evaluation of nerve cuff electrodes

Cited by 17 publications

References 6 publications

Efficient Objective Metric Tool for Medical Electrical Device Development: Eye Phantom for Glaucoma Diagnosis Device

Efficient Objective Metric Tool for Medical Electrical Device Development: Eye Phantom for Glaucoma Diagnosis Device

The Physical Axon : Modeling, Simulation and Electrode Evaluation

A phantom axon setup for validating models of action potential recordings

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