An Aqueous-Ethanol Extract ofLiriope spicatavar.proliferaAmeliorates Diabetic Nephropathy through Suppression of Renal Inflammation

Abstract

The tuberous root of Liriope spicata var. prolifera (TRLS; Liliaceae family) is valued for the ability to promote glucose homeostasis, and it may therefore be utilized as an adjuvant therapy in the control of diabetic complications. The aim of the present study was to examine the effects of an aqueous ethanol extract from TRLS (TRLS-ext) (100 or 200 mg kg−1 per day for eight weeks) on rats with streptozotocin-induced diabetic nephropathy (DN). Renal dysfunction in diabetic rats was ameliorated by TRLS-ext as evidenced by reduced creatinine clearance, as well as increased blood urea nitrogen and proteinuria. Treatment with TRLS-ext was found to markedly improve histological architecture in the diabetic kidney. Hyperglycemia induced degradation of inhibitory kappa B and reduced nuclear factor kappa B activation, leading to increased infiltration of macrophages and increased levels of proinflammatory cytokines, including interleukin-1 and tumor necrosis factor-α. All of the above abnormalities were reversed by TRLS-ext treatment, which also decreased the expression of intercellular adhesion molecule-1, monocyte chemoattractant protein-1, and fibronectin in the diabetic kidneys. These findings provide a perspective on the renoprotective effects of TRLS-ext in DN.

Effect of compounds isolated from Filicium decipiens and Ventilago madraspatana against diabetic nephropathy in streptozotocin induced diabetic rats

“…The changes in markers of diabetic nephropathy in our study were consistent with previous report. [17][18][19] We also demonstrated in our study that administration of combination of rutin and quercetin could influence these parameters in the diabetic nephropathy rats. Streptozotocin administration to rats increased plasma glucose and decreased insulin levels.…”

Protective effect of magnesium on renal function in STZ-induced diabetic rats

“…The right kidney of the animals in all groups were identified, resected, dried by tissue papers and weighed by digital scale on Sartorius balance to determine the change in the weight of organs with respect to their body weights. A change in kidney size was estimated by division the weight of the right kidney to total body weight [ 1 ]. The kidney was removed from each rat, put into 10% formalin and embedded in paraffin.…”

“…Diabetic nephropathy is a major long-term complication of Type 1 diabetes mellitus (T1D) [ 1 - 3 ]. It develops in more than of 40% of patients in spite of glucose control [ 4 ].…”

Liriopogons (Genera Ophiopogon and Liriope, Asparagaceae): A Critical Review of the Phytochemical and Pharmacological Research

“…Moreover, they also exerted anti-diabetic effects on insulin-resistant diabetic KKAy mice through up-regulating the expression of insulin-receptor (InsR), insulin-receptor substrate-1 (IRS-1), phosphatidylinositol 3-kinase, and PPAR γ ( Liu et al, 2013 ). The anti-diabetic activity of aqueous-ethanol extract of L. spicata was observed through inhibiting the expression of ICAM-1, MCP-1, and fibronectin protein and inflammatory cytokines ( Lu et al, 2013 ).…”