An aptasensor for troponin I based on the aggregation-induced electrochemiluminescence of nanoparticles prepared from a cyclometallated iridium(III) complex and poly(4-vinylpyridine-co-styrene) deposited on nitrogen-doped graphene

Saremi, Mohammad; Amini, Amir; Heydari, Hamid

doi:10.1007/s00604-019-3352-6

Cited by 42 publications

(8 citation statements)

References 35 publications

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“…123 This method achieved a LDR of 20−1200 fM and a LOD of 8.5 fM. The detection of cTnI was also demonstrated by a few other aptasensors, including an electrochemiluminescent biosensor (LDR, 0.1 pM−10 nM; LOD, 20 fM), 135 a luminescent biosensor (LDR, 60−2400 ng/ L; LOD, 12 ng/L), 136 a colorimetric paper sensor (LDR, 0.01−48.31 ng/mL; LOD, 0.23 pg/mL), 137 and a fluorescent biosensor (LDR, 0.10−6.0 ng/mL; LOD, 0.07 ng/mL). 138 Three papers described the combination of aptamers and nanomaterials to set up unique aptasensors to detect troponins.…”

Section: ■ Aptamersmentioning

confidence: 93%

Biosensors Made of Synthetic Functional Nucleic Acids Toward Better Human Health

et al. 2019

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Section: ■ Aptamersmentioning

confidence: 93%

Biosensors Made of Synthetic Functional Nucleic Acids Toward Better Human Health

et al. 2019

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“…Enlightened by this work, detection of a myocardial infarction biomarker by quantification of troponin I in blood serum was developed . Based on AIECL of nanoparticles, a cyclometalated iridium(III) complex and poly(4‐vinylpyridine‐ co ‐styrene) were deposited on nitrogen‐doped graphene.…”

Section: Aiecl Luminophoresmentioning

confidence: 99%

“…After that, a novel disposable ECL aptasensor was reported for early detection of troponin I (TI), which indicated acute myocardial infarction (MI) occurrence and the most life‐threatening sorts of cardiovascular diseases in the human body . This bio‐sensing platform was prepared step‐by‐step with fabrication of nitrogen‐doped graphene (NG), aptamer‐modified gold nanoparticles (AuNPs‐Apt), and cyclometalated iridium(III)‐poly‐4‐vinylpyridine nanoparticles (CIPNPs) on carbon screen‐printed electrodes (CSPE).…”

Section: Applicationsmentioning

confidence: 99%

Recent Advances in Aggregation‐Induced Electrochemiluminescence

Wang

Zhu

Yan

et al. 2019

Chemistry A European J

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The emergence of the rising alliance between aggregation‐induced emission (AIE) and electrochemiluminescence (ECL) is defined as aggregation‐induced electrochemiluminescence (AIECL). The booming science of AIE has proved to be not only distinguished in luminescent materials but could also inject new possibility into ECL analysis. Especially in the aqueous phase and solid state for hydrophobic materials, AIE helps ECL circumvent the dilemma between substantial emission intensity and biocompatible media. The wide range of analytes makes ECL an overwhelmingly interesting analytical technique. Therefore, AIECL has gained potential in clinical diagnostics, environmental assays, and biomarker detections. This review will focus on introduction of the novel concept of AIECL, current applied luminophores, and related applications developed in recent years.

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“…Here the ECL emission was enhanced through aggregation in nanoparticles allowing a remarkably low detection limit of troponin I down to 20 fM with a relative standard deviation of 3.1 %, which is one of the lowest reported. In addition, the aptamer used in the ECL sensor resulted highly selective in presence of other cardiac markers like cytochrome C, bovine serum albumin, troponin T and C …”

Section: Classes Of Ecl‐active Metallopolymersmentioning

confidence: 99%

Metallopolymers as Nanostructured Solid‐State Platforms for Electrochemiluminescence Applications

2019

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Electrochemiluminescence (ECL) is the process of light emission arising from an electrochemically generated excited state. ECL has been demonstrated to be a powerful tool for bioanalysis, in particular when phosphorescent transition metal complexes (TMCs) are used as emitters. Apart from molecular luminophores, there has been increasing interest in the use of both non‐conjugated and π‐conjugated metallopolymers over the last decade. Research efforts in this direction are driven by the appealing possibility to synergistically combine typical features of polymers, such as processability, with the enhanced photophysical and redox properties of several classes of TMCs. Indeed, solid‐state arrangements of ECL‐active metallopolymers enable their straightforward use as sensors with enhanced response. This concept article focuses on ECL‐active metallopolymers and their use in solid‐state platforms, providing a survey with relevant examples together with properties, mechanisms and proposed applications. Finally, the outlook for future applications across different research fields for these materials as well as their limitations for will be discussed.

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An aptasensor for troponin I based on the aggregation-induced electrochemiluminescence of nanoparticles prepared from a cyclometallated iridium(III) complex and poly(4-vinylpyridine-co-styrene) deposited on nitrogen-doped graphene

Cited by 42 publications

References 35 publications

Biosensors Made of Synthetic Functional Nucleic Acids Toward Better Human Health

Biosensors Made of Synthetic Functional Nucleic Acids Toward Better Human Health

Recent Advances in Aggregation‐Induced Electrochemiluminescence

Metallopolymers as Nanostructured Solid‐State Platforms for Electrochemiluminescence Applications

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