An aptamer-based quartz crystal microbalance biosensor for sensitive and selective detection of leukemia cells using silver-enhanced gold nanoparticle label

Ultra-high frequency piezoelectric aptasensor for the label-free detection of cocaine

“…TSM is a powerful technique that allows for the real-time detection of mass loading and viscoelastic changes at the liquid/sensor interface (Keller and Kasemo, 1998;Stavila et al, 2012). This technology has been widely implemented in the study and detection of biological interactions, primarily the detection of DNA oligos and protein; also several aptasensors against protein, DNA and cellular targets have been built on this technology (He et al, 2014;Ozalp et al, 2015;Shan et al, 2014;Song et al, 2014;Wang and Li, 2013). However, the detection of small organic molecules is rarely reported, due to the small mass and viscoelastic changes produced by the adsorption/binding of such small entities to the sensor surface (Chen et al, 2011;Dong and Zhao, 2012;Sheng et al, 2011).…”

Noble metal nanoparticles in biosensors: recent studies and applications

“…Modified AuNPs were also used in an aptamer-based sensor to label leukemia cells. After capturing the cells on the QCM, the AuNP catalyzed Ag deposition, which led to a decrease in resonant frequency [39]. While the strategy in most piezoelectric sensors is converting an increase in mass to a signal, in the reverse strategy, the mass lost due to dissolution of AuNPs in QCM-based biosensors was utilized for Pb 2+ detection.…”

“…Based upon their specific properties, NPs can act as immobilizing platforms [27–31], accelerate electron transfer [32, 33], catalyze the reaction of chemiluminecents with their substrates [34–37], amplify changes in mass [38, 39] and enhance refractive index (RI) changes [40, 41]. For instance, in addition to immobilizing the bioreceptors, MNPs can act as “electron wires” in electrochemical biosensors, which allow electrons produced in bioreactions to be transported to sensing electrodes or convert other physiochemical changes to measurable signals that are proportional to the analyte concentration [32].…”

A paper-based detection method of cancer cells using the photo-thermal effect of nanocomposite

“…In order to diagnose breast cancer at an early stage, detection and identification of breast cancer cells is fundamental [1]. Currently, there are many different types of techniques to detect cells, such as immunocytochemistry [2], electrochemical methods [3], microfluidic devices [4] and biosensors [5]. Although they are very useful laboratory tests and have high sensitivity, many of these methods are expensive and require advanced instruments.…”