An approach to evaluate the efficacy of vaginal misoprostol administered for a rapid management of first trimester spontaneous onset incomplete abortion, in comparison to surgical curettage

Patua, Bijan; Dasgupta, Mandira; Bhattacharyya, Sanjoy Kumar; Bhattacharya, Sohini; Hasan, Shirazee Hasibul; Saha, Sudip

doi:10.1007/s00404-013-2894-9

Cited by 9 publications

(4 citation statements)

References 16 publications

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“…Our findings revealed that women considered misoprostol to be effective as it was successful in evacuating the uterus. These findings are similar to what most studies have portrayed [ 15 – 17 , 19 – 22 , 35 , 36 ]. Very high levels of effectiveness of above 90% have been reported in most studies with a few showing a slightly reduced level of effectiveness (80–89%).…”

Section: Discussionsupporting

confidence: 91%

Women’s perceptions of and experiences with the use of misoprostol for treatment of incomplete abortion in central Malawi: a mixed methods study

et al. 2023

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Background Abortion-related complications are among the common causes of maternal mortality in Malawi. Misoprostol is recommended for the treatment of first-trimester incomplete abortions but is seldom used for post-abortion care in Malawi. Methods A descriptive cross-sectional study that used mixed methods was conducted in three hospitals in central Malawi. A survey was done on 400 women and in-depth interviews with 24 women receiving misoprostol for incomplete abortion. Convenience and purposive sampling methods were used and data were analysed using STATA 16.0 for quantitative part and thematic analysis for qualitative part. Results From the qualitative data, three themes emerged around the following areas: experienced effects, support offered, and women’s perceptions. Most women liked misoprostol and reported that the treatment was helpful and effective in expelling retained products of conception. Quantitative data revealed that the majority of participants, 376 (94%) were satisfied with the support received, and 361 (90.3%) believed that misoprostol was better than surgical treatment. The majority of the women 364 (91%) reported they would recommend misoprostol to friends. Conclusions The use of misoprostol for incomplete abortion in Malawi is acceptable and regarded as helpful and satisfactory among women.

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Section: Discussionsupporting

confidence: 91%

Women’s perceptions of and experiences with the use of misoprostol for treatment of incomplete abortion in central Malawi: a mixed methods study

et al. 2023

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“…A total of 114 RCTs were included in the review . The PRISMA flow chart in Figure S1 shows study selection.…”

Section: Resultsmentioning

confidence: 99%

Outcomes in prevention and management of miscarriage trials: a systematic review

Smith

Dhillon-Smith

O’Toole

et al. 2018

BJOG

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Background There is a substantial body of research evaluating ways to prevent and manage miscarriage, but all studies do not report on the same outcomes. Objective To review systematically, outcomes reported in existing miscarriage trials. Search strategy MEDLINE, Embase, CINAHL, and Cochrane were searched from inception until January 2017. Selection criteria Randomised controlled trials (RCTs) reporting prevention or management of miscarriage. Miscarriage was defined as a pregnancy loss in the first trimester. Data collection and analysis Data about the study characteristics, primary, and secondary outcomes were extracted. Main results We retrieved 1553 titles and abstracts, from which 208 RCTs were included. For prevention of miscarriage, the most commonly reported primary outcome was live birth and the top four reported outcomes were pregnancy loss/stillbirth (n = 112), gestation of birth (n = 68), birth dimensions (n = 65), and live birth (n = 49). For these four outcomes, 58 specific measures were used for evaluation. For management of miscarriage, the most commonly reported primary outcome was efficacy of treatment. The top four reported outcomes were bleeding (n = 186), efficacy of miscarriage treatment (n = 105), infection (n = 97), and quality of life (n = 90). For these outcomes, 130 specific measures were used for evaluation. Conclusions Our review found considerable variation in the reporting of primary and secondary outcomes along with the measures used to assess them. There is a need for standardised patient‐centred clinical outcomes through the development of a core outcome set; the work from this systematic review will form the foundation of the core outcome set for miscarriage. Tweetable abstract There is disparity in the reporting of outcomes and the measures used to assess them in miscarriage trials.

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“…In 2010 indications for abortions in Finland were social in 92%, medical in 0.5% and fetal defect-related in 3% of the cases. Other indications comprised 5% of the cases, including indications such as mother's age (under 17 or over 40 years) [15]. Surgical evacuation-dilatation has for decades been the standard treatment of early pregnancy termination.…”

Section: Discussionmentioning

confidence: 99%

“…All patients were primarily offered the medical procedure [15] [16]. Medical abortion is standard procedure in our clinic and it is primarily offered of all patients including women less than 63 days of gestation.…”

Section: Methodsmentioning

confidence: 99%

A Simple Procedure for Termination of Pregnancy in the Late First Trimester with Mifeprostone and Misoprostol

Joensuu-Manninen¹,

Nissi²,

Santala³

et al. 2015

OJOG

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Purpose: To assess the efficacy of medical methods for termination of pregnancy at 9 -12 weeks of gestation. Methods: Between December 2008 and December 2010, the 116 consecutive women received 200 mg oral mifepristone and after 24 -36 hours they applied 800 µg vaginal misoprostol to medically terminate pregnancy. If the products of conception did not pass, three further doses of 400 µg misoprostol were given vaginally at three hours intervals to medically terminate pregnancy. Results: Of the 116 patients undergoing the procedure 104 (90%) aborted completely. Half of the patients aborted within 6 hours. After medical termination, five per cent of the women were treated because of infection, and five per cent needed a revisit to hospital because of excessive bleeding. Two women received a blood transfusion. Previous live births or previous inducted abortion is presented in the study results. Conclusions: Medical abortion at 9 -12 weeks' gestation is a safe alternative to surgery.

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An approach to evaluate the efficacy of vaginal misoprostol administered for a rapid management of first trimester spontaneous onset incomplete abortion, in comparison to surgical curettage

Abstract: Misoprostol could be a safe and easily accessible alternative to surgical evacuation, in cases of first trimester spontaneous onset incomplete miscarriage, and could be administered by the patient herself at home.

Cited by 9 publications

References 16 publications

Women’s perceptions of and experiences with the use of misoprostol for treatment of incomplete abortion in central Malawi: a mixed methods study

Women’s perceptions of and experiences with the use of misoprostol for treatment of incomplete abortion in central Malawi: a mixed methods study

Outcomes in prevention and management of miscarriage trials: a systematic review

A Simple Procedure for Termination of Pregnancy in the Late First Trimester with Mifeprostone and Misoprostol

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