An appraisal of the new operational definition of epilepsy—Then and now

Malkan, Ashish; Beran, Roy G.

doi:10.1016/j.yebeh.2014.09.084

Cited by 4 publications

(2 citation statements)

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“…To reduce diagnostic ambiguity and promote a better understanding of the pathogenesis of epilepsy and seizures, the International League Against Epilepsy (ILAE) recently proposed a new definition of epilepsy (Malkan and Beran, 2014), which encompasses the following clinical scenarios: i) at least two unprovoked (or reflex) seizures occurring more than 24 hours apart; ii) one unprovoked (or reflex) seizure and a probability of further seizures similar to the general recurrence risk (at least 60%) after two unprovoked seizures, occurring over the next 10 years; iii) an established diagnosis of an epilepsy syndrome. Seizures can be either generalized (characterized by diffuse epileptiform discharges involving distributed neuronal networks bilaterally) or focal (discrete localization and involvement limited to one hemisphere).…”

Section: Introductionmentioning

confidence: 99%

Women with epilepsy: clinically relevant issues

Bangar¹,

Shastri²,

El‐Sayeh³

et al. 2016

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SummaryWomen with epilepsy (WWE) face specific challenges throughout their lifespan due to the effects of seizures and antiepileptic drugs on hormonal function, potentially affecting both sexual and reproductive health. This review article addresses the most common issues of practical relevance to clinicians treating WWE: epidemiology and clinical presentations (including catamenial epilepsy), contraception, reproductive and sexual dysfunction, pregnancy, lactation, menopause-related issues (including bone health), and mental health aspects. Awareness of these gender-specific issues and implementation/adaptation of effective interventions for WWE results in significantly improved health-related quality of life in this patient population.

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Section: Introductionmentioning

confidence: 99%

Women with epilepsy: clinically relevant issues

Bangar¹,

Shastri²,

El‐Sayeh³

et al. 2016

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“…To reduce diagnostic ambiguity and promote a better understanding of the pathogenesis of epilepsy and seizures, the International League Against Epilepsy (ILAE) recently proposed a new definition of epilepsy, which encompasses the following clinical scenarios: i) at least two unprovoked (or reflex) seizures occurring more than 24 hours apart; ii) one unprovoked (or reflex) seizure and a probability of further seizures similar to the general recurrence risk (at least 60%) after two unprovoked seizures, occurring over the next 10 years; iii) an established diagnosis of an epilepsy syndrome. 13 Focal seizures are further classified as motor/sensory and dyscognitive, whereas generalized seizures encompass tonic-clonic, absence, myoclonic, tonic, clonic or atonic seizures. 14 As currently defined, epilepsy is considered to be resolved in patients who have remained seizure-free for at least 10 years and off antiepileptic drugs (AEDs) for at least five years.…”

Section: Definitionmentioning

confidence: 99%

Premature Ovarian Failure and Epilepsy

Permana

Rahmi

Muhammad

2021

AOJ

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Premature ovarian failure (POF) or premature menopause refers to development of amenorrhoea due to cessation of ovarian function before the age of 40 years. The diagnosis is based on elevated FSH levels in menopausal range (usually above 40 IU/l) detected on at least two occasions a few weeks apart. The term “epilepsy” defines a group of disorders characterized by an enduring predisposition of the brain to produce seizures. The hypothalamic-pituitary-ovarian axis regulation is affected by the abnormal neurophysiology of seizures, and the hypothalamic-pituitary-ovarian associated hormones are affected by medications used to treat seizures in women with epilepsy. Ictal and interictal discharges can disrupt the normal activity of brain structures, including the limbic system, amygdala, hypothalamus, and pituitary gland. Management of epilepsy in women requires not only knowledge of epilepsy, but also recognition of the various roles and priorities women have in their lives (education, career development, child rearing, the role as carer within the extended family), and attention to gender-specific issues and their impact on patients’ wellbeing throughout life.Keywords: premature ovarian failure (POF), epilepsy

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