Anesthesia considerations for patients with epilepsy: Findings of a qualitative study in the Palestinian practice

Jaber, Mohammad; Shawahna, Ramzi; Abu-Issa, Majd; Radwan, Faris; Dweik, Mohammad

doi:10.1016/j.yebeh.2021.108278

Cited by 9 publications

(6 citation statements)

References 42 publications

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“…In addition, a noncooperative pediatric patient may present with peculiarities directly related to the underlying pathology: for those with autism spectrum disorder difficulties in cooperation and communication and possible drug interactions between home therapy and drugs administered for anesthetic premedication and anesthesia [12,13]; for those with Down's syndrome the presence of congenital heart defects, peculiar craniofacial anatomical features, atlantoaxial instability, and obesity [13][14][15]; for those with infantile cerebral palsy or spastic tetraparesis sialorrhea, scoliosis, gastroesophageal reflux, and low subcutaneous fat [16,17]; finally, for those with epilepsy there may be drug interactions between antiepileptic therapy and drugs administered as anesthetic premedication or as anesthetics, with an increased risk of seizures [18].…”

Section: Discussionmentioning

confidence: 99%

Airway Management and General Anesthesia in Pediatric Patients with Disabilities Undergoing Dental Surgery: A Retrospective Study

Ciccozzi,

Lupi,

Necozione

et al. 2024

Preprint

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The definition of patients with Special Needs (SN) is used in the literature to refer to individuals with mental and physical disorders for whom the usual perioperative pathways are not applicable due to lack of cooperation, regardless of age. Studies in the literature recognize the appropriateness of general anesthesia for performing day surgery dental care in this type of patient. The present retrospective, single-center, observational study involved 41 uncooperative patients aged between 3 and 17 undergoing dental surgery under general anesthesia. The main objective was to assess the possible incidence of difficult airway management, understood as difficulty ventilating and/or intubating the patient. A secondary objective was to highlight the influence of general anesthesia on patient outcomes by testing the incidence of perioperative complications. Tracheal intubation was successfully completed in all of the patients considered, and in no case did the patient have to be woken up because of difficulty in airway management. No perioperative complications attributable to anesthesia were found in any patients. From the present experience, it can be concluded that general anesthesia is a suitable option for performing dental care in pediatric subjects with special needs, and that although the peculiar peri-operative management of these patients might increase the risk of possible anesthesia-related side effects, no complications have been encountered in any case.

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Section: Discussionmentioning

confidence: 99%

Airway Management and General Anesthesia in Pediatric Patients with Disabilities Undergoing Dental Surgery: A Retrospective Study

Ciccozzi,

Lupi,

Necozione

et al. 2024

Preprint

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“…In this qualitative study, thematic saturation was used to determine the endpoint of the interviews. Informed by previous qualitative studies that were conducted with healthcare providers, thematic saturation was expected to be achieved in about 5 h of interview time [ 13 , 19 – 21 ]. Assuming an average interview duration of 30 min, interviews with 10 healthcare providers were expected to achieve thematic saturation in this study.…”

Section: Methodsmentioning

confidence: 99%

“…In the absence of adequate nurse-to-patient ratios, providers of healthcare services in the neonatal intensive care units are often overwhelmed with their daily workloads. Moreover, healthcare providers in hospitals often report receiving insufficient guidelines and training relevant to the safe prescribing, preparation, administration, and monitoring of medications [ 10 – 13 ]. Together, these working conditions increase the likelihood of medication errors in neonatal intensive care units.…”

Section: Introductionmentioning

confidence: 99%

Medication errors in neonatal intensive care units: a multicenter qualitative study in the Palestinian practice

et al. 2022

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Background Neonatal intensive care units are high-risk settings where medication errors can occur and cause harm to this fragile segment of patients. This multicenter qualitative study was conducted to describe medication errors that occurred in neonatal intensive care units in Palestine from the perspectives of healthcare providers. Methods This exploratory multicenter qualitative study was conducted and reported in adherence to the consolidated criteria for reporting qualitative research checklist. Semi-structured in-depth interviews were conducted with healthcare professionals (4 pediatricians/neonatologists and 11 intensive care unit nurses) who provided care services for patients admitted to neonatal intensive care units in Palestine. An interview schedule guided the semi-structured in-depth interviews. The qualitative interpretive description approach was used to thematically analyze the data. Results The total duration of the interviews was 282 min. The healthcare providers described their experiences with 41 different medication errors. These medication errors were categorized under 3 categories and 10 subcategories. Errors that occurred while preparing/diluting/storing medications were related to calculations, using a wrong solvent/diluent, dilution errors, failure to adhere to guidelines while preparing the medication, failure to adhere to storage/packaging guidelines, and failure to adhere to labeling guidelines. Errors that occurred while prescribing/administering medications were related to inappropriate medication for the neonate, using a different administration technique from the one that was intended, and administering a different dose from the one that was intended. Errors that occurred after administering the medications were related to failure to adhere to monitoring guidelines. Conclusion In this multicenter study, pediatricians/neonatologists and neonatal intensive care unit nurses described medication errors occurring in intensive care units in Palestine. Medication errors occurred in different stages of the medication process: preparation/dilution/storage, prescription/administration, and monitoring. Further studies are still needed to quantify medication errors occurring in the neonatal intensive care units and investigate if the designed strategies could be effective in minimizing the medication errors.

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“…Accumulating evidence suggests that anthocyanins exert multifaceted protective effects on neurons, mitigating apoptotic pathways implicated in AD pathogenesis [ 53 ]. Firstly, anthocyanins possess potent antioxidant properties, scavenging free radicals and reducing oxidative stress, which are known to trigger apoptotic cascades in neurons [ 71 ]. Anthocyanins regulate mitochondrial function, an important determinant of programmed cell death.…”

Section: Protective Effects Of Anthocyanins Neuronal Apoptosismentioning

confidence: 99%

“…In AD, disruption of proteostasis ( Figure 3 ) leads to the accumulation of misfolded proteins, including Aβ plaques and tau tangles, which contribute to neurological dysfunction and cognitive decline [ 82 , 83 ]. Protein imbalance in AD involves the impairment of various cellular pathways, such as the ubiquitin–proteasome system (UPS), the autophagy–lysosomal pathway (ALP), and chaperone-mediated protein folding [ 71 , 84 ]. Dysfunction of these pathways results in an inability to appropriately remove misfolded proteins, leading to their aggregation and toxicity.…”

Section: Anthocyanins On Proteostasismentioning

confidence: 99%

Therapeutic Effects of Plant Anthocyanin against Alzheimer’s Disease and Modulate Gut Health, Short-Chain Fatty Acids

Bayazid,

Lim

2024

Nutrients

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Alzheimer’s disease (AD) is the most common form of dementia and neurogenerative disease (NDD), and it is also one of the leading causes of death worldwide. The number of AD patients is over 55 million according to 2020 Alzheimer’s Disease International (ADI), and the number is increasing drastically without any effective cure. In this review, we discuss and analyze the potential role of anthocyanins (ACNs) against AD while understanding the molecular mechanisms. ACNs have been reported as having neuroprotective effects by mitigating cognitive impairments, apoptotic markers, neuroinflammation, aberrant amyloidogenesis, and tauopathy. Taken together, ACNs could be an important therapeutic agent for combating or delaying the onset of AD.

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Anesthesia considerations for patients with epilepsy: Findings of a qualitative study in the Palestinian practice

Cited by 9 publications

References 42 publications

Airway Management and General Anesthesia in Pediatric Patients with Disabilities Undergoing Dental Surgery: A Retrospective Study

Airway Management and General Anesthesia in Pediatric Patients with Disabilities Undergoing Dental Surgery: A Retrospective Study

Medication errors in neonatal intensive care units: a multicenter qualitative study in the Palestinian practice

Therapeutic Effects of Plant Anthocyanin against Alzheimer’s Disease and Modulate Gut Health, Short-Chain Fatty Acids

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