An Application of Polymer Gel, which Contains Phosphate Groups in Side Chain, to Drug Delivery Contact Lens

Sato, Takao; Uchida, Rei; Tanigawa, Haruyasu; Uno, Kenji

doi:10.1295/koron.60.235

Cited by 3 publications

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“…Thus, drug administration based on the characteristic of uptake of substances has been vigorously investigated. [1][2][3][4] Among them, instillation in the eye over a SCL and fitting a SCL saturated with eyedrops to extend contact with the cornea by holding the medication inside the SCL are already clinically practiced. In this manner, however, SCLs will suffer contour alteration caused by the uptake of the drug, which may compromise their safety to the cornea.…”

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confidence: 99%

The Interaction and Compatibility Between a Soft Contact Lens and an Ophthalmic Drug

Kanemoto

Sato

Aoyama

et al. 2006

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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confidence: 99%

The Interaction and Compatibility Between a Soft Contact Lens and an Ophthalmic Drug

Kanemoto

Sato

Aoyama

et al. 2006

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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“…In a recent report on the other hand, the zwitterionic SCL was utilized in a drug delivery system (DDS) 6–9. In the report, the drug is encapsulated in the hydrous gel through the ionic interaction between the cationic functional groups in SCL and the anionic drug substance.…”

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confidence: 99%

Analysis and evaluation of the ionic interaction of the novel soft contact lenses using the zwitterionic polymer gel

Yamazaki¹,

Matsunaga²,

Ichinokawa³

et al. 2009

J of Applied Polymer Sci

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In the zwitterionic polymer gel which has cationic and anionic groups inside, it forms a complex to producing stability by adding thermal energy. We reported the behavior induced by the ionic interaction of them and the impact that a nonionic surfactant could exert on the complex formation. We had heating experiments of the zwitterionic polymer gel in PBS with a nonionic surfactant added. We analyzed DSC and measured the diameter, stress and flexure of heated the gel. As the result, it has been demonstrated that formation of strong ionic interactions inside the gel can be achieved by heating them in a solution containing the nonionic surfactant. It has been also demonstrated that the ratio of bound water is increased within the gel, promising an enhanced strength.

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Application of polymer gels containing side‐chain phosphate groups to drug‐delivery contact lenses

Sato

Uchida²,

Tanigawa³

et al. 2005

J of Applied Polymer Sci

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Hydrogels that contain phosphate groups in side chains were studied for their usefulness in drug-delivery soft contact lenses (SCLs). Naphazoline, a model drug having a cationic group, was incorporated into an SCL because of its phosphate groups and was released over a period of about 14 h. For the SCL, the naphazoline content was equivalent to the phosphate group content. It is suggested that drug-delivery SCLs can be designed to contain the needed amount of a drug through the choice of the ionic group for the ligand. Furthermore, the SCL having amide groups and phosphate groups had high transparency and an unchanged shape. It is suggested that amide groups and phosphate groups must be introduced into the polymer in equimolar amounts to give the necessary polymer-drug interaction. Therefore, hydrogels having a drug-delivery system were synthesized by the inclusion of a phosphate group and an amide group. These hydrogels are also applicable to SCL materials.

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An Application of Polymer Gel, which Contains Phosphate Groups in Side Chain, to Drug Delivery Contact Lens

Cited by 3 publications

References 0 publications

The Interaction and Compatibility Between a Soft Contact Lens and an Ophthalmic Drug

The Interaction and Compatibility Between a Soft Contact Lens and an Ophthalmic Drug

Analysis and evaluation of the ionic interaction of the novel soft contact lenses using the zwitterionic polymer gel

Application of polymer gels containing side‐chain phosphate groups to drug‐delivery contact lenses

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