An application of ionic liquid for preparation of homogeneous collagen and alginate hydrogels for skin dressing

Iqbal, Bilal; Muhammad, Nawshad; Jamal, Arshad; Ahmad, Pervaiz; Khan, Zia Ul Haq; Rahim, Abdur; Khan, Amir Sada; Gonfa, Girma; Iqbal, Jibran; Rehman, Ihtesham Ur

doi:10.1016/j.molliq.2017.08.101

Cited by 44 publications

(25 citation statements)

References 17 publications

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“…Hemolysis experiments were used to examine the toxicity of the PNIPA/MSN composite hydrogels, with 0.9% physiological saline solution used as the negative control (1% hemolysis) and distilled water as the positive control (100% hemolysis). When the hemolysis rate exceeds 5%, a sample is considered to be toxic . As shown in Figure , all PNIPA/MSN composite hydrogels had a hemolysis rate of less than 1%.…”

Section: Resultsmentioning

confidence: 99%

Poly(N‐isopropylacrylamide)/mesoporous silica thermosensitive composite hydrogels for drug loading and release

Zhang

Wang

Waterhouse

et al. 2019

J of Applied Polymer Sci

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Temperature‐sensitive hydrogels are attracting increasing attention for controlled drug delivery. However, achieving high drug loadings and sustained drug release remains challenging. Herein, we describe the successful synthesis of a series of novel temperature‐sensitive poly(N‐isopropylacrylamide) (PNIPA)/mesoporous silica nanoparticles (MSN) hydrogels by physical crosslinking of NIPA with MSN. The external and internal structures, temperature sensitivity, drug‐loading capacity, and blood compatibility of the PNIPA/MSN composite hydrogels are studied. Results show that MSN addition improved the network structure and adjusted the size of the hole, MSN could also act as drug carrier, thereby enhancing the drug loading capacity. The composite hydrogels underwent a phase transition at 33.7 °C (at the lower critical solution temperature). The hemolysis rate of the composite hydrogels was less than 1%, thus they can be classified as a nonhemolytic materials with good biocompatibility. The composite hydrogels reported here thus have great potential in drug transport and temperature‐activated drug release. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48391.

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Section: Resultsmentioning

confidence: 99%

Poly(N‐isopropylacrylamide)/mesoporous silica thermosensitive composite hydrogels for drug loading and release

Zhang

Wang

Waterhouse

et al. 2019

J of Applied Polymer Sci

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“…Among the materials designated as polymers, alginate is a polysaccharide of particular interest. In addition to the benefits already highlighted above, alginate is hydrophilic in nature, has low toxicity, and is relatively inexpensive [3,4]. The alginate polymer is composed of linear chains of α-L-guluronic acid (G) and β-D-manuronic acid (M) blocks identified as rigid and flexible blocks, respectively.…”

Section: Introductionmentioning

confidence: 99%

Thermal, microstructural, and spectroscopic analysis of Ca2+ alginate/clay nanocomposite hydrogel beads

Fernandes

Moura

Glenn

et al. 2018

Journal of Molecular Liquids

104

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Polymeric hydrogels are important biomaterials with potential for various applications including the controlled release of drugs. Clay and zeolite nanostructures can enhance the absorption and release properties of hydrogels. In our previous work, a procedure was optimized for making hydrogel beads. The objectives of this study were to use the optimized bead forming procedure to prepare clay and zeolite nanocomposite hydrogel beads and characterize their microstructure, thermal and chemical properties. The hydrogels were prepared by dripping solutions of either sodium alginate or sodium alginate/nanostructure (clay and/or zeolite) into beakers containing different concentrations of CaCl 2 at 25°C. Fourier transform infrared spectroscopy (FTIR) analysis detected the presence of functional groups associated with alginate, clay and zeolite. The microstructure of the alginate beads was somewhat rough with small protrusions. Flakes were visible in micrographs of beads containing nanoclay. The elemental composition of the hydrogels was investigated by energy dispersive X-ray spectrometry (EDX). EDX spectra revealed magnesium, sodium, aluminum, silicon and increased the levels of oxygen in the nanoclay compositions. The incorporation of nanoclays decreased the percentage of organic matter lost as detected by thermogravimetric analysis (TG). TG was also able to detect the incorporation of nanoclay in hydrogels. The nanoclays proved to be more effective than zeolites in producing alginate hydrogels with satisfactory swelling characteristics.

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“…Those hydrogels supported the adhesion and growth of primary human dermal fibroblasts, suggesting that they could be useful in skin regeneration approaches. In a similar study [86], an IL-namely, 1-methylimidazolium acetate ([Mim)(OAc))-facilitated the formation of alginate/collagen hydrogels with high hemocompatibility and satisfactory biocompatibility assessed by rat mesenchymal stem cells (rMSC), which rendered them as promising for skin dressings. Beyond that, another report showed that an IL, (Emim)(OAc), promoted the production of an electrically conducting chitin scaffold permissive for mesenchymal stem cell functions [127].…”

Section: Biocompatibilitymentioning

confidence: 99%

“…The sterical constraints due to proline and hydroxyproline cause the collagen regions with this tripeptide repeat to adopt three left-handed polypeptide chains (called α helices), which self-assemble to form at least one right-handed triple-helical domain [72,76,77], providing not only structural support for cells but, also, acting as an important regulator of cell behavior [78]. Collagen can be isolated from natural products, being relatively nonimmunogenic and, consequently biocompatible, opening the possibility to use it in a wide range of applications in commercial fields, including food [79,80], cosmetics [80][81][82], and medicine [72,[83][84][85][86]. However, collagen application is tremendously limited by the strong inter-and intramolecular hydrogen and ionic bonds, van der Waals' forces, and hydrophobic bonds between the polar and nonpolar groups, which have extremely difficult collagen dissolution and consequent processing [71].…”

Section: Collagenmentioning

confidence: 99%

“…Another successful approach is the dissolution of collagen using ionic liquids (ILs) as a solvent. In this approach, the IL interacts with collagen by a hydrogen bond, promoting its dissolution [38,71,86]. Imidazolium-based ILs have brought about significant changes at the higher structural hierarchical level of collagen, developing a different hierarchical ordering [40].…”

Section: Collagenmentioning

confidence: 99%

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Marine-Derived Polymers in Ionic Liquids: Architectures Development and Biomedical Applications

et al. 2020

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Marine resources have considerable potential to develop high-value materials for applications in different fields, namely pharmaceutical, environmental, and biomedical. Despite that, the lack of solubility of marine-derived polymers in water and common organic solvents could restrict their applications. In the last years, ionic liquids (ILs) have emerged as platforms able to overcome those drawbacks, opening many routes to enlarge the use of marine-derived polymers as biomaterials, among other applications. From this perspective, ILs can be used as an efficient extraction media for polysaccharides from marine microalgae and wastes (e.g., crab shells, squid, and skeletons) or as solvents to process them in different shapes, such as films, hydrogels, nano/microparticles, and scaffolds. The resulting architectures can be applied in wound repair, bone regeneration, or gene and drug delivery systems. This review is focused on the recent research on the applications of ILs as processing platforms of biomaterials derived from marine polymers.

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An application of ionic liquid for preparation of homogeneous collagen and alginate hydrogels for skin dressing

Cited by 44 publications

References 17 publications

Poly(N‐isopropylacrylamide)/mesoporous silica thermosensitive composite hydrogels for drug loading and release

Poly(N‐isopropylacrylamide)/mesoporous silica thermosensitive composite hydrogels for drug loading and release

Thermal, microstructural, and spectroscopic analysis of Ca2+ alginate/clay nanocomposite hydrogel beads

Marine-Derived Polymers in Ionic Liquids: Architectures Development and Biomedical Applications

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