An antitumor compound julibroside J28 from Albizia julibrissin

Triterpenoid saponins from Albizia lebbeck (L.) Benth and their inhibitory effect on the survival of high grade human brain tumor cells

“…This aglycon was thus recognized to be acacic acid (3b,16a,21b-trihydroxyolean-12-ene-28-oic acid) by comparison of its 1 H and 13 C NMR signals with those reported in the literature. [9][10][11][12][13][14][15][16][17][18][19][20][21] The downfield position of the axial group at C-14 (Me-27, d 1.84) in the 1 H NMR spectrum, implied an additional axial (a) hydroxyl group at C-16. The ROESY correlations observed between H-21 (d 5.37) and H-29 (d 1.01, s), suggested an a-axial orientation of H-21, as well as between H-3 (d 3.49) and H-5 (d 0.82) indicated the a-axial orientation of the two protons.…”

A review of acacic acid-type saponins from Leguminosae-Mimosoideae as potent cytotoxic and apoptosis inducing agents

“…By the same way, additional molecules, julibroside J 28 (29) and julibroside J 14 (30) were obtained (Fig. 7 Liang et al 2005). The study of the stem bark led to the isolation of four minor saponins, julibrosides J 21 , J 29 , J 30 and J 31 (31-34) (Fig.…”

Genetic fidelity assessment of in vitro-regenerated plants of Albizia julibrissin using SCoT and IRAP fingerprinting

“…It has been reported that two secondary metabolites from the tree pods have the potential to act as biocides and antioxidants (Lv et al 2011). The triterpenoid julibroside J 28 from the bark of the plant significantly inhibited the growth of three tumor cell lines in vitro (Liang et al 2005). The anti-tumor properties of three minor saponin extracts (Zheng et al 2006) and the cytotoxic effect of bark extracts on human acute leukemia Jurkat T cells have also been reported (Won et al 2006).…”

“…Active natural products of great pharmaceutical interest include triterpenoid saponins (Kinjo et al 1992;Liang et al 2005;Han et al 2011), phenolic glycosides (Jung et al 2004), and flavonoids (Lau et al 2007). It has been reported that two secondary metabolites from the tree pods have the potential to act as biocides and antioxidants (Lv et al 2011).…”