An Antioxidative Metabolite of Penicillium herquei as a Potent Synergist for Tocopherol

Atrovenetin as a potent antioxidant compound from penicillium species

“…As reported in previous papers (12,14), new herqueinonerelated antioxidants have been isolated from PeniciUium species and exhibited excellent synergistic activities with Toa The correlation between structure and antioxidation of herqueinone derivatives is now being investigated. As reported in previous papers (12,14), new herqueinonerelated antioxidants have been isolated from PeniciUium species and exhibited excellent synergistic activities with Toa The correlation between structure and antioxidation of herqueinone derivatives is now being investigated.…”

“…Aoyama et al (6) isolated the antioxidative phenolic compounds--citrinin, protocatechuic acid and curvulic acid--from fungi. We also have reported that some microbial metabolites are potent antioxidants and Toc synergists in several fat substrates with excellent activity compared to that of Toc alone (9)(10)(11)(12)(13)(14). We also have reported that some microbial metabolites are potent antioxidants and Toc synergists in several fat substrates with excellent activity compared to that of Toc alone (9)(10)(11)(12)(13)(14).…”

Fatty acids and glycerides

“…~" Leaves of the oil palm contain high levels of a -t o c o p h e r ~l , ~' ~ and the content of tocopherols and tocotrienols in Finnish foods has been A new class of natural antioxidants, consisting of a polyhydroxynaphthoquinone system, has been identified600 while an antioxidative metabolite that has a synergistic effect on the action of tocopherol has been isolated from Penicilliurn herquei. 601 The effect of antioxidants and the oxidative stability of avocado oil have been studied.112*113 A lignan compound, sesaminol, appears to possess strong antioxidative activity and is found in unroasted sesame-seed…”

Purification and Characterization of the Antioxidative Substance Produced byAspergillus sojaeK

“…The effects of pH (1-14) on the antioxidative substance was measured by measuring the residual activity on incubation at 50°C for 90 min. The buffer systems used were: HCI-KCI (pH 1-2), citric acid-Na2HP04 (pH 3-8), Na2C03-H3B03-KCI (pH 9-10), NaOH-Na 2 HP0 4 (pH 11-12), and KOH-HCl (pH [13][14]. The activity was affected in the pH range 1 to 3 and it was found that about 800/0 activity was lost at pH 1 and about 6% at pH 3.…”