An Antimicrobial Evaluation of &lt;i&gt;Vernonia amygdalina&lt;/i&gt; (&lt;i&gt;Compositae&lt;/i&gt;) Against Gram - Positive and Gram - Negative Bacteria from Lagos, Nigeria

Iwalokun, BA; Bamiro, S. B.; Durojaiye, O. A.

doi:10.4314/wajpdr.v19i1.14726

Cited by 10 publications

(14 citation statements)

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“…This observation agrees with the work of Iwalokun (2003), who reported on the effectiveness of V. amygdalina leaf extract. In his study, V. amygdalina leaf extract dose restored efficacy of chloroquine against chloroquineresistant Plasmodium beiglei strains.…”

Section: Discussionsupporting

confidence: 83%

“…However, in previous studies by Iwalokun (2003), he reported the antimicrobial activity of V. amygdalina leaf extracts on standard strains of E. coli ATCC25922 and Staphylococcus aureus ATCC 25923. The result obtained in this study on Staphylococcus sp and E. coli may be as a result of strain differences from standard strains used in the above research.…”

Section: Discussionmentioning

confidence: 99%

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Antimicrobial activity of Vernonia amygdalina on selected urinary tract pathogens

Uzoigwe¹,

Agwa²

2011

Afr. J. Microbiol. Res.

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The aqueous ethanol and acetone-ethanolic extracts of Vernonia amygdalina leaves and stems were investigated for their antimicrobial activities compared to ciprofloxacin, against Escherichia coli, Klebsiella sp and Staphylococcus sp. The antimicrobial activity of each extract on the isolates was determined by agar well diffusion and minimum inhibitory concentration methods. The acetoneethanolic extract of the leaf showed the highest antibacterial activity on Klebsiella sp in both methods used, followed by the ethanol leaf extracts on the same organism. E. coli and Staphylococcus sp were not susceptible to any of the extracts even at higher concentrations. The aqueous extracts of both leaf and stem were ineffective on all the test isolates at all concentration. Comparatively, the test isolates were sensitive to ciprofloxacin in both methods used but the antibacterial effect of acetone-ethanolic leaf extract on Klebsiella sp was higher than that of ciprofloxacin on Klebsiella sp. The results from this research showed that V. amygdalina could be used as raw material in the synthesis of antimicrobial drugs, especially against Klebsiella sp which have been attributed with high level drug resistance in urinary tract infections.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of Vernonia amygdalina on selected urinary tract pathogens

Uzoigwe¹,

Agwa²

2011

Afr. J. Microbiol. Res.

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“…Preliminary investigation of vibriocidal activities of Ogi tutu, V. amygdalina and P. guajava showed in vitro vibriocidal activities. These agreed with findings on antibacterial activities documented in the literature 16,19,[22][23][24] .…”

Section: Discussionsupporting

confidence: 81%

“…Also, several plants are used locally in the treatment of diarrhoea [11][12][13][14] . Psidium guajava L. and Vernonia amygdalina [15][16] are two of such plants that are used in SouthWest Nigeria. Vernonia amygdalina is a dark green vegetable known as bitter leaf in English, and ewuro in Yoruba land 17 .…”

Section: Introductionmentioning

confidence: 99%

Intestinal ameliorative effects of traditional Ogi-tutu, Vernonia amygdalina and Psidium guajava in mice infected with Vibrio cholera

Shittu¹,

Ajayi²,

Bankole³

et al. 2016

Afr H. Sci.

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Background: Cholera, a severe acute watery diarrhea caused by Vibrio cholerae is endemic in Nigeria with most cases occurring in the rural areas. In South West Nigeria, some individuals resort to alternative treatments such as Ogi-tutu, Psidium guajava and Vernonia amygdalina during infections. The effectiveness of these alternatives in the prevention and treatment of V. cholerae infection requires experimental investigation. Objective: This study was designed to investigate the ameliorative effects of Ogi-tutu, Vernonia amygdalina and Psidium guajava on intestinal histopathology of experimental mice infected with V. cholerae. Methods: Preliminary investigation of in vitro vibriocidal activities of these alternatives were carried out using agar cup diffusion assay. For ameliorative effects, adult mice were inoculated with 100 μl (106 cells) of Vibrio cholerae and dosed at 0 h (immediate prevention) and 4 h (treatment of infection) and their intestines were histopathologically evaluated. Results: The histopathological changes were the same irrespective of the treated groups, but the lesions varied in extent and severity. The ameliorative effects in decreasing order were V. amygdalina > P. guajava > Ogi-tutu. Conclusion: V. amygdalina gave the best ameliorative effects in the prevention and treatment of V. cholerae infection.

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“…Vernonia amygdalina leaf (commonly known as bitter leaf) is one of the most widely used herbal preparation, especially in Sub-Saharan Africa. Despite the various pharmacological studies on the use of herbal medicines (Iwalokun et al, 2004(Iwalokun et al, , 2006Ojiako and Nwanjo, 2006;Anoka et al, 2008;Taiwo et al, 2009;Asuquo et al, 2010), there are still information draught respect to the identity of therapeutically effective and safe quality of the herb (World Health Organization, 2005). To address some of the impeding challenges in using the herb for malarial therapy therefore, this study was aimed at evaluating the pharmacognostic properties of the leaf, and the antiplasmodial and antipyretic properties of the leaf aqueous extract.…”

Section: Introductionmentioning

confidence: 99%

Pharmacognostic, antiplasmodial and antipyretic evaluation of the aqueous extract of <i>Vernonia amygdalina</i> leaf

Adiukwu¹,

Amon²,

Nambatya³

2011

International Journal of Biological and Chemical Sciences

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The impeding safety challenges to the use of herbs have made qualitative and quantitative evaluation of herbal preparations a necessity. This study was aimed at evaluating the pharmacognostic and pharmacological properties of V. amygdalina leaf. Methods used include standard procedure for macroscopic and microscopic examinations; ash and extractive values determination; and quantitative evaluation of phytochemicals of the leaf aqueous extract. 4-day antiplasmodial suppression test using mice and antipyretic evaluation in rats induced pyrexia by i.p administration of 15% and dose induced body temperature decrease, were significant (P ≤ 0.05) for all the 3 dose levels of the extract used. Study agrees with folkloric use of the leaf extract in malaria fever but suggests substantial antipyretic property of the leaf.

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An Antimicrobial Evaluation of <i>Vernonia amygdalina</i> (<i>Compositae</i>) Against Gram - Positive and Gram - Negative Bacteria from Lagos, Nigeria

Cited by 10 publications

References 0 publications

Antimicrobial activity of Vernonia amygdalina on selected urinary tract pathogens

Antimicrobial activity of Vernonia amygdalina on selected urinary tract pathogens

Intestinal ameliorative effects of traditional Ogi-tutu, Vernonia amygdalina and Psidium guajava in mice infected with Vibrio cholera

Pharmacognostic, antiplasmodial and antipyretic evaluation of the aqueous extract of <i>Vernonia amygdalina</i> leaf

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