Antimicrobial activity of Vernonia amygdalina on selected urinary tract pathogens

Uzoigwe, Chibuzo; Agwa, O. K.

doi:10.5897/ajmr10.866

Cited by 18 publications

(12 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stem and leaf extracts of V. amygdalina have also been reported for antimicrobial role against Klebisella spp. (Uzoigwe & Agwa, 2011). The same authors have also shown that E. coli is not susceptible to extracts of V. amygdalina, which matches our own finding.…”

Section: Discussionsupporting

confidence: 90%

Antimicrobial activity of traditional medicinal plants from Ankober District, North Shewa Zone, Amhara Region, Ethiopia

Lulekal

Rondevaldova

Bernaskova

et al. 2014

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 90%

Antimicrobial activity of traditional medicinal plants from Ankober District, North Shewa Zone, Amhara Region, Ethiopia

Lulekal

Rondevaldova

Bernaskova

et al. 2014

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…It has also been demonstrated that the acetone-ethanol extract of the leaves from V. amygdalina was weakly active against K . pneumoniae, E. coli, S. aureus , B. cereus, S. dysentriae and S. typhimurium [35] with MIC values ranged from 7.5 mg/mL to 25 mg/mL [42]. These activities are in accordance with the results obtained in the present work, but we observed higher antibacterial activity of this plant on all 29 bacteria including MDR phenotypes (with MIC values ranging between 256 and 1024 μg/mL).…”

Section: Discussionsupporting

confidence: 92%

In Vitro antibacterial and antibiotic-potentiation activities of four edible plants against multidrug-resistant gram-negative species

Noumedem

Mihășan

Kuiaté

et al. 2013

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundThe present study was designed to investigate the antibacterial activities of the methanol extracts of four Cameroonian edible plants, locally used to treat microbial infections, and their synergistic effects with antibiotics against a panel of twenty nine Gram-negative bacteria including Multi-drug resistant (MDR) phenotypes expressing active efflux pumps.MethodsThe broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) of the extracts [alone and in the presence of the efflux pumps inhibitor (EPI) Phenylalanine-Arginine β-Naphtylamide (PAβN)], and those of antibiotics in association with the two of the most active ones, Piper nigrum and Telfairia occidentalis. The preliminary phytochemical screening of the extracts was conducted according to the standard phytochemical methods.ResultsPhytochemical analysis showed the presence of alkaloids and flavonoids in all studied extracts. Other chemical classes of secondary metabolites were selectively present in the extracts. The results of the MIC determination indicated that the crude extracts from P. nigrum and V. amygdalina were able to inhibit the growth of all the twenty nine studied bacteria within a concentration range of 32 to 1024 μg/mL. At a similar concentration range (32 to 1024 μg/mL) the extract from T. occidentalis inhibited the growth of 93.1% of the tested microorganisms. At MIC/2 and MIC/5, synergistic effects were noted between the extracts from P. nigrum and T. occidentalis and seven of the tested antibiotics on more than 70% of the tested bacteria.ConclusionThe overall results of the present study provide information for the possible use of the studied edible plants extracts in the control of bacterial infections including MDR phenotypes.

show abstract

“…The aqueous extracts of the plant samples were less active on the test organisms compared to the raw and alcohol extracts. This agrees with previous reports 12,25 that aqueous extracts of G. latifolium showed no activity against S. aureus and E. coli even at high concentrations. It was observed that in both forms of extraction i.e.…”

Section: Phytochemical Analysissupporting

confidence: 94%

Time-Dependent Evaluation Of The Antibacterial And Phytochemical Properties Of Vernonia Amygdalina And Gongronema Latifolium

2012

IJHPM

View full text Add to dashboard Cite

Background: Many plants in Africa are medicinal including domesticated edible vegetables. The time-dependent antibacterial efficacy of two popular Nigerian vegetables (Vernonia amygdalina and Gongronema latifolium) on clinical isolates of Staphylococcus aureus and Escherichia coli was evaluated. Phytochemical compositions were also evaluated using direct chemical estimation and thin layer chromatography respectively. Methods : Leaves were extracted with aqueous and alcoholic solvents at 2 hours and 72 hours at various concentrations and tested against bacteria using the agar well diffusion method. Minimum inhibitory/bactericidal concentrations were also determined. Results: Ethanol extracts of fresh leaves were more active than methanol extracts when were decocted in 98% alcoholic concentrations. The highest zone size obtained was 18mm at 125mg/ml concentration of ethanol extract against S. aureus. Activity was most prominent at 2 hours of decoction. Both plants had inhibition values of 2500 μg/ml each on E. coli as MIC and MBC while G. latifolium showed 5000 μg/ml each as MIC and MBC and V. amygdalina showed 625μg/ml each as MIC and MBC values respectively on S. aureus. The plants were shown to have ample quantities of saponins, flavonoids and alkaloids. Conclusions: This result has shown the relative potency of edible vegetables against bacteria. The level of phytochemical compounds bitter vegetable plants contain points to the usefulness of G. latifolium and Vernonia amydalina as credible supplements for antibiotics when used fresh or used as fresh solvent decoctions.

show abstract

Antimicrobial activity of Vernonia amygdalina on selected urinary tract pathogens

Cited by 18 publications

References 15 publications

Antimicrobial activity of traditional medicinal plants from Ankober District, North Shewa Zone, Amhara Region, Ethiopia

Antimicrobial activity of traditional medicinal plants from Ankober District, North Shewa Zone, Amhara Region, Ethiopia

In Vitro antibacterial and antibiotic-potentiation activities of four edible plants against multidrug-resistant gram-negative species

Time-Dependent Evaluation Of The Antibacterial And Phytochemical Properties Of Vernonia Amygdalina And Gongronema Latifolium

Contact Info

Product

Resources

About